1.14.14.18: heme oxygenase (biliverdin-producing)
This is an abbreviated version!
For detailed information about heme oxygenase (biliverdin-producing), go to the full flat file.
Word Map on EC 1.14.14.18
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1.14.14.18
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monoxide
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cytoprotective
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endothelial
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necrosis
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dismutase
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protoporphyrin
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erythroid
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2-related
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tnf
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bilirubin
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artery
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malondialdehyde
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lipopolysaccharide
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catalase
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hemin
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neuroprotective
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ischemia
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gsh
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lps
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sod
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anti-oxidant
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mapks
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sirna
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caspase-3
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quinone
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pulmonary
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reperfusion
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lps-induced
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hypoxia
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cyclooxygenase-2
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cox-2
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ferritin
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erk
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nf-e2-related
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anti-apoptotic
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cobalt
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myeloperoxidase
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ischemia-reperfusion
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nrf2-mediated
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pro-oxidant
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kelch-like
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nadph:quinone
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factor-2
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lps-stimulated
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2-like
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erythroid-derived
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oxygenases
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delta-aminolevulinic
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sulforaphane
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hyperbilirubinemia
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medicine
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drug development
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analysis
- 1.14.14.18
- monoxide
-
cytoprotective
- endothelial
- necrosis
- dismutase
- protoporphyrin
-
erythroid
-
2-related
- tnf
- bilirubin
- artery
- malondialdehyde
- lipopolysaccharide
- catalase
- hemin
-
neuroprotective
- ischemia
- gsh
- lps
- sod
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anti-oxidant
- mapks
- sirna
- caspase-3
- quinone
- pulmonary
-
reperfusion
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lps-induced
- hypoxia
- cyclooxygenase-2
- cox-2
- ferritin
- erk
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nf-e2-related
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anti-apoptotic
- cobalt
- myeloperoxidase
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ischemia-reperfusion
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nrf2-mediated
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pro-oxidant
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kelch-like
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nadph:quinone
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factor-2
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lps-stimulated
-
2-like
-
erythroid-derived
- oxygenases
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delta-aminolevulinic
- sulforaphane
- hyperbilirubinemia
- medicine
- drug development
- analysis
Reaction
Synonyms
biliverdin-producing heme oxygenase, ChuS, ChuZ, EC 1.14.99.3, haem oxygenase, heme oxygenase, heme oxygenase 1, heme oxygenase 2, heme oxygenase-1, heme oxygenase-2, HemO, Hmox1, Hmox1a, Hmox1b, Hmox2, Hmox2a, Hmox2b, HmuO, Hmx1, HO, HO-1, HO-2, Ho1, Ho2, Ho3, HO4, HSP32, HugZ, HY1, inducible heme oxygenase-1, More, MsHO1, ORP33 proteins, oxygenase, heme (decyclizing), pbsA1, PigA, proteins, specific or class, ORP33 (oxygen-regulated protein 33,000-mol.-wt.), Syn HO-1, Syn HO-2
ECTree
1.14.14.18 heme oxygenase (biliverdin-producing)Advanced search results
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results (Organism
Organism on EC 1.14.14.18 - heme oxygenase (biliverdin-producing)
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ORGANISM 
COMMENTARY 
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
two types of isoforms: an inducible heme oxygenase-1, HO1, and a constitutive heme oxygenase-2/3, HO2/3
UniProt
heme oxygenase-1 is identical to the major 32000 Da mammalian stress-protein inducible by heat shock, H2O2, ultraviolet-A radiation, NaAsO2, pro-inflammatory cytokines, bacterial endotoxins, growth factors, NO, and tumor promotors, heme oxygenase-1 confers protection against oxidative stress
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heme oxygenase is induced by light and delta-aminolevulinic acid, induction is inhibited by D-glucose
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684386, 684502, 684777, 684789, 684932, 685099, 685495, 685815, 685997, 686118, 686555, 686599, 686898, 687181, 687555, 687576
UniProt
2 isoforms: heme oxygenase-1, inducible, heme oxygenase-2, constitutive
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288603, 438243, 438244, 438247, 438248, 438249, 438250, 438259, 438261, 438270, 438273, 438275, 438276
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heme oxygenase-1 is a heat shock protein that is inducible by numerous stimuli, including heavy metals, oxidative stress and injury, and cytokines, a 3 isomer, heme oxygenase-3, exhibits 90% homology to heme oxygenase-2, its mRNA has been detected in several tissues including kidney
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inducible isozyme HO-1, constitutive isozyme HO-2
UniProt
enzyme induction by curcumin is dramatically reduced by decreasing the temperature from 37°C to 10°C, cells pretreated with curcumin at 37°C or during a programmed decrease in temperature exhibit increased resistance to oxidative stress-mediated injury
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