1.14.14.19: steroid 17alpha-monooxygenase

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For detailed information about steroid 17alpha-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.19

1.14.14.19

adrenal

androgen

progesterone

testosterone

steroidogenesis

androstenedione

cortisol

cyp17a1

dehydroepiandrosterone

estrogen

pregnenolone

aromatase

testicular

acth

estradiol

adrenocortical

polycystic

p450scc

hypokalemia

21-hydroxylase

dheas

3beta-hydroxysteroid

17-hydroxyprogesterone

mineralocorticoid

ketoconazole

p450arom

orteronel

abiraterone

17alpha-hydroxyprogesterone

17-hydroxypregnenolone

amenorrhea

hyperandrogenism

reticularis

theca

3beta-hsd

acth-stimulated

17alpha-hydroxylation

delta4

aminoglutethimide

11-deoxycorticosterone

alpha-hydroxypregnenolone

adrenarche

pseudohermaphroditism

11-deoxycortisol

17-hydroxylation

nci-h295r

cyp21a2

c19-steroids

hypergonadotropic

nonsteroidogenic

analysis

drug development

medicine

Reaction

Synonyms

17 alpha-hydroxylase/C17,20-lyase, 17,20-lyase, 17-alpha-hydroxylase/C17-20 lyase, 17-hydroxylase/17,20-lyase, 17-hydroxylase/C17,20-lyase, 17alphahydroxylase, 17alpha-hydroxylase, 17alpha-hydroxylase 17,20 lyase, 17alpha-hydroxylase-17,20-lyase, 17alpha-hydroxylase-C17,20 lyase, 17alpha-hydroxylase-C17,20-lyase, 17alpha-hydroxylase/17,20 lyase, 17alpha-hydroxylase/17,20-lyase, 17alpha-hydroxylase/C(17,20)-lyase, 17alpha-OHase, 17OHD, CYP 17, CYP17, CYP17A1, CYPXVII, cytochrome P-450 (P45017alpha,lyase), cytochrome P-45017alpha, cytochrome P450 17, cytochrome P450 17A1, cytochrome P450 17A2, cytochrome P450 17alpha-hydroxylase, cytochrome P450 17alpha-hydroxylase-17,20-lyase, cytochrome P450 17alpha-hydroxylase/17,20 lyase, cytochrome P450 17alpha-hydroxylase/17,20-lyase, cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase, cytochrome P450 17alpha-hydroxylase/C17,20-lyase, cytochrome P450 17alpha-hydroxylase/c17-20 lyase, cytochrome P45017alpha, cytochrome P450c17, cytochrome P450c17alpha, cytochromeP450 17alpha-hydroxylase/C17-20 lyase, EC 1.14.1.7, EC 1.14.99.9, EC 1.99.1.9, P450 17, P450 17A1, P450(17alpha), P450-17alpha, P450-C17, P45017alpha, P450c17, P450c17-I, Steroid 17-alpha-hydroxylase/17,20 lyase, steroid 17alpha-hydroxylase, steroidogenic cytochrome P450 17A1

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.19 steroid 17alpha-monooxygenase

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Results	in table
12	Activating Compound
840	AA Sequence
12	Application
1	CAS Registry Number
45	Cloned(Commentary)
42	Cofactor
4	Crystallization (Commentary)
698	Disease/ Diagnostics
5	Expression
91	General Information
246	IC50 Value
500	Inhibitors
10	kcat/KM [mM/s]
55	Ki Value [mM]
47	KM Value [mM]
48	Localization
11	Metals/Ions
8	Molecular Weight [Da]
140	Natural Substrates/ Products (Substrates)
294	Organism
8	Pathway
34	PDB ID
26	pH Optimum
5	Posttranslational Modification
52	Protein Variants
20	Purification (Commentary)
2	Reaction
10	Reaction Type
124	Reference
149	Source Tissue
9	Specific Activity [micromol/min/mg]
3	Storage Stability
181	Substrates and Products (Substrate)
6	Subunits
156	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
1	Temperature Range [°C]
18	Turnover Number [1/s]

Cofactor

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Cofactor on EC 1.14.14.19 - steroid 17alpha-monooxygenase

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cytochrome b5

cytochrome P450

ferrocytochrome b5

heme

NADPH