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1.14.14.19: steroid 17alpha-monooxygenase

This is an abbreviated version!
For detailed information about steroid 17alpha-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.19

Reaction

a C21-steroid
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
a 17alpha-hydroxy-C21-steroid
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

17 alpha-hydroxylase/C17,20-lyase, 17,20-lyase, 17-alpha-hydroxylase/C17-20 lyase, 17-hydroxylase/17,20-lyase, 17-hydroxylase/C17,20-lyase, 17alphahydroxylase, 17alpha-hydroxylase, 17alpha-hydroxylase 17,20 lyase, 17alpha-hydroxylase-17,20-lyase, 17alpha-hydroxylase-C17,20 lyase, 17alpha-hydroxylase-C17,20-lyase, 17alpha-hydroxylase/17,20 lyase, 17alpha-hydroxylase/17,20-lyase, 17alpha-hydroxylase/C(17,20)-lyase, 17alpha-OHase, 17OHD, CYP 17, CYP17, CYP17A1, CYPXVII, cytochrome P-450 (P45017alpha,lyase), cytochrome P-45017alpha, cytochrome P450 17, cytochrome P450 17A1, cytochrome P450 17A2, cytochrome P450 17alpha-hydroxylase, cytochrome P450 17alpha-hydroxylase-17,20-lyase, cytochrome P450 17alpha-hydroxylase/17,20 lyase, cytochrome P450 17alpha-hydroxylase/17,20-lyase, cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase, cytochrome P450 17alpha-hydroxylase/C17,20-lyase, cytochrome P450 17alpha-hydroxylase/c17-20 lyase, cytochrome P45017alpha, cytochrome P450c17, cytochrome P450c17alpha, cytochromeP450 17alpha-hydroxylase/C17-20 lyase, EC 1.14.1.7, EC 1.14.99.9, EC 1.99.1.9, P450 17, P450 17A1, P450(17alpha), P450-17alpha, P450-C17, P45017alpha, P450c17, P450c17-I, Steroid 17-alpha-hydroxylase/17,20 lyase, steroid 17alpha-hydroxylase, steroidogenic cytochrome P450 17A1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.19 steroid 17alpha-monooxygenase

KI Value

KI Value on EC 1.14.14.19 - steroid 17alpha-monooxygenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.005
1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-imidazole
-
more than 0.005000
0.000112
1-((9H-fluoren-2-yl)ethyl)-1H-imidazole
-
-
0.000388
1-((9H-fluoren-2-yl)methyl)-1H-imidazole
-
-
0.0031
1-(1-(4'-(methylsulfanyl)biphenyl-4-yl)propyl)-1H-imidazole
-
more than 0.003100
0.005
1-(1-(4'-(trifluoromethoxy)biphenyl-4-yl)propyl)-1H-imidazole
-
more than 0.005000
0.002
1-(1-(4'-ethylbiphenyl-4-yl)propyl)-1H-imidazole
-
more than 0.002000
0.005
1-(1-(4'-fluorobiphenyl-4-yl)allyl)-1H-imidazole
-
more than 0.005000
0.005
1-(1-(4'-methylbiphenyl-4-yl)propyl)-1H-imidazole
-
more than 0.005000
0.0014
1-(1-(biphenyl-4-yl)allyl)-1H-imidazole
-
-
0.00046
1-(1-biphenyl-4-yl-2,2-dimethyl-propyl)-1H-imidazole
-
-
0.00031
1-(1-biphenyl-4-yl-2-methyl-propyl)-1H-imidazole
-
-
0.00078
1-(1-biphenyl-4-yl-2-phenyl-ethyl)-1H-imidazole
-
-
0.00079
1-(1-biphenyl-4-yl-2-phenyl-methyl)-1H-imidazole
-
-
0.0021
1-(1-biphenyl-4-yl-3-methyl-butyl)-1H-imidazole
-
-
0.00058
1-(1-biphenyl-4-yl-butyl)-1H-imidazole
-
-
0.00105
1-(1-biphenyl-4-yl-cyclohexyl-methyl)-1H-imidazole
-
-
0.0003
1-(1-biphenyl-4-yl-pentyl)-1H-imidazole
-
-
0.00045
1-(1-biphenyl-4-yl-propyl)-1H-imidazole
-
-
0.0023
1-(1-bis-biphenyl-4-yl-methyl)-1H-imidazole
-
-
0.0038
1-(2-(4'-fluorobiphenyl-4-yl)propan-2-yl)-1H-imidazole
-
-
0.0013
1-(3-(4'-fluorobiphenyl-4-yl)pentan-3-yl)-1H-imidazole
-
-
0.000756
1-(3-chloro-1-(4'-fluorobiphenyl-4-yl)propyl)-1H-imidazole
-
-
0.000345
1-[1-(4'-fluoro-biphenyl-4-yl)propyl]-1H-imidazole
-
-
0.000168
1-[1-(7-fluoro-9H-fluoren-2-yl)ethyl]-1H-imidazole
-
-
0.00008
17-(1H-1,2,3-triazol-1-yl)androsta-4,16-dien-3-one
-
noncompetitive inhibitor
0.000041
17-(1H-1,2,4-triazol-1-yl)androsta-4,16-dien-3-one
-
noncompetitive inhibitor
0.0000019
17-(1H-imidazol-1-yl)androsta-4,16-dien-3-one
-
noncompetitive inhibitor
0.0003 - 0.0008
17-hydroxypregnenolone
0.00124 - 0.0096
17alpha-hydroxyandrosten-3-one
0.000118
2-(1-(1H-imidazol-1-yl)ethyl)-7-fluoro-9H-carbazole
-
-
0.000282
2-(1-imidazol-1-yl-ethyl)-9H-carbazole
-
-
0.000029
22-Amino-23,24-bisnor-5-cholen-3beta-ol
-
17alpha-hydroxylase activity
0.005
3-(4'-fluorobiphenyl-4-yl)-3-(1H-imidazol-1-yl)propan-1-ol
-
more than 0.005000
0.00004
3-(6-Chloro-3-methyl-2-indenyl)pyridine
-
-
0.0000014
3beta-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene
-
noncompetitive inhibitor
0.000023
3beta-hydroxy-17-(1H-1,2,4-triazol-1-yl)androsta-5,16-diene
-
noncompetitive inhibitor
0.0000012
3beta-hydroxy-17-(1H-imidazol-1-yl)androsta-5,16-diene
-
noncompetitive inhibitor
0.005
4'-(1-(1H-imidazol-1-yl)propyl)biphenyl-4-carbonitrile
-
more than 0.005000
0.000375
4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-ol
-
-
0.0003
4-chloro-3,4-dihydro-2-(3-pyridyl)-1-(2H)-naphthalenone
-
-
0.0022
4-[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-morpholine
-
-
0.000099
7-(1-(1H-imidazol-1-yl)ethyl)-9H-fluoren-2-ol
-
-
0.000072
abiraterone
-
-
0.005
diethyl-[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-amine
-
more than 0.005000
0.00278
ketoconazole
-
-
0.005
N-[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-acetamide
-
more than 0.005000
0.0008
pregnenolone
-
competitive substrate with progesterone
0.0032
progesterone
-
competitive substrate with pregnenolone
0.0000000464
transforming growth factor-beta1
-
-
-
0.0017
[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-carbamic acid tert-butyl ester
-
-
0.005
[4'-(1H-imidazol-1-yl-propyl)-biphenyl-4-yl]-dimethyl-amine
-
more than 0.005000