1.14.14.19: steroid 17alpha-monooxygenase

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For detailed information about steroid 17alpha-monooxygenase, go to the full flat file.

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Synonyms

17 alpha-hydroxylase/C17,20-lyase, 17,20-lyase, 17-alpha-hydroxylase/C17-20 lyase, 17-hydroxylase/17,20-lyase, 17-hydroxylase/C17,20-lyase, 17alpha
hydroxylase, 17alpha-hydroxylase, 17alpha-hydroxylase 17,20 lyase, 17alpha-hydroxylase-17,20-lyase, 17alpha-hydroxylase-C17,20 lyase, 17alpha-hydroxylase-C17,20-lyase, 17alpha-hydroxylase/17,20 lyase, 17alpha-hydroxylase/17,20-lyase, 17alpha-hydroxylase/C(17,20)-lyase, 17alpha-OHase, 17OHD, CYP 17, CYP17, CYP17A1, CYPXVII, cytochrome P-450 (P45017alpha,lyase), cytochrome P-45017alpha, cytochrome P450 17, cytochrome P450 17A1, cytochrome P450 17A2, cytochrome P450 17alpha-hydroxylase, cytochrome P450 17alpha-hydroxylase-17,20-lyase, cytochrome P450 17alpha-hydroxylase/17,20 lyase, cytochrome P450 17alpha-hydroxylase/17,20-lyase, cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase, cytochrome P450 17alpha-hydroxylase/C17,20-lyase, cytochrome P450 17alpha-hydroxylase/c17-20 lyase, cytochrome P45017alpha, cytochrome P450c17, cytochrome P450c17alpha, cytochromeP450 17alpha-hydroxylase/C17-20 lyase, EC 1.14.1.7, EC 1.14.99.9, EC 1.99.1.9, P450 17, P450 17A1, P450(17alpha), P450-17alpha, P450-C17, P45017alpha, P450c17, P450c17-I, Steroid 17-alpha-hydroxylase/17,20 lyase, steroid 17alpha-hydroxylase, steroidogenic cytochrome P450 17A1

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.19 steroid 17alpha-monooxygenase

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Results	in table
12	Activating Compound
840	AA Sequence
12	Application
1	CAS Registry Number
45	Cloned(Commentary)
42	Cofactor
4	Crystallization (Commentary)
698	Disease/ Diagnostics
5	Expression
91	General Information
246	IC50 Value
500	Inhibitors
10	kcat/KM [mM/s]
55	Ki Value [mM]
47	KM Value [mM]
48	Localization
11	Metals/Ions
8	Molecular Weight [Da]
140	Natural Substrates/ Products (Substrates)
294	Organism
8	Pathway
34	PDB ID
26	pH Optimum
5	Posttranslational Modification
52	Protein Variants
20	Purification (Commentary)
2	Reaction
10	Reaction Type
124	Reference
149	Source Tissue
9	Specific Activity [micromol/min/mg]
3	Storage Stability
181	Substrates and Products (Substrate)
6	Subunits
156	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
1	Temperature Range [°C]
18	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.14.19 - steroid 17alpha-monooxygenase

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SYSTEMATIC NAME

IUBMB Comments

steroid,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)

Requires NADPH and EC 1.6.2.4, NADPH---hemoprotein reductase. A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17alpha-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis, and the conversion of the 17alpha-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis (EC 1.14.14.32, 17alpha-hydroxyprogesterone deacetylase). The ratio of the 17alpha-hydroxylase and 17,20-lyase activities is an important factor in determining the directions of steroid hormone biosynthesis towards biosynthesis of glucocorticoid or sex hormones.