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1.14.14.20: phenol 2-monooxygenase (FADH2)

This is an abbreviated version!
For detailed information about phenol 2-monooxygenase (FADH2), go to the full flat file.

Word Map on EC 1.14.14.20

Reaction

phenol
+
FADH2
+
O2
=
catechol
+
FAD
+
H2O

Synonyms

FAD reductase, flavin reductase PheA2, PheA, PheA1, PheA2, phenol hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.20 phenol 2-monooxygenase (FADH2)

Inhibitors

Inhibitors on EC 1.14.14.20 - phenol 2-monooxygenase (FADH2)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-hydroxymercuribenzoate
complete inhibition at 0.02 mM
Ag+
0.02 mM completely inhibits; complete inhibition at 0.02 mM
Co2+
1 mM inhibits by 20%; 20% inhibition at 1 mM
Cu2+
0.02 mM completely inhibits; complete inhibition at 0.02 mM
FAD
with respect to the total phenol hydroxylase activity, concentrations higher than 0.01 mM inhibit the catalyzed reaction; with respect to the total phenol hydroxylase activity, concentrations higher than 0.01 mM inhibit the catalyzed reaction
Fe2+
1 mM inhibits by 49%; 49% inhibition at 1 mM
Fe3+
0.1 mM inhibits by 23%, 1 mM completely inhibits; complete inhibition at 1 mM
N-ethylmaleimide
0.1 mM inhibits by 38%, 1 mM completely inhibits; complete inhibition at 1 mM
Ni2+
0.1 mM inhibits by 79%, 1 mM completely inhibits; complete inhibition at 1 mM
p-hydroxymercuribenzoate
0.0005 mM inhibits by 53%,0.02 mM completely inhibits the enzymic activity
Zn2+
1 mM inhibits by 77%; 77% inhibition at 1 mM
additional information
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