1.14.14.20: phenol 2-monooxygenase (FADH2)
This is an abbreviated version!
For detailed information about phenol 2-monooxygenase (FADH2), go to the full flat file.
Word Map on EC 1.14.14.20
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1.14.14.20
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two-component
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rhodococcus
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thermoglucosidasius
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catechols
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erythropolis
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isoalloxazine
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prosthetic
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nadh-dependent
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reductases
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fmnh2
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hydroxylases
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ping-pong
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homotetramer
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hydride
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environmental protection
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4-hydroxyphenylacetate
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fad-containing
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synthesis
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styrene
- 1.14.14.20
-
two-component
- rhodococcus
- thermoglucosidasius
- catechols
- erythropolis
- isoalloxazine
-
prosthetic
-
nadh-dependent
- reductases
- fmnh2
- hydroxylases
-
ping-pong
-
homotetramer
-
hydride
- environmental protection
- 4-hydroxyphenylacetate
-
fad-containing
- synthesis
- styrene
Reaction
Synonyms
FAD reductase, flavin reductase PheA2, PheA, PheA1, PheA2, phenol hydroxylase
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.14.14.20 - phenol 2-monooxygenase (FADH2)
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REACTION DIAGRAM
4-methylphenol + FADH2 + O2
4-methylcatechol + FAD + H2O
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2,4-dichlorocatechol + FAD + H2O
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?
2,4-dichlorophenol + FADH2 + O2
2,4-dichlorocatechol + FAD + H2O
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-
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?
2-chlorocatechol + FAD + H2O
poor substrate for isozyme PheA1(1)
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-
?
2-chlorophenol + FADH2 + O2
2-chlorocatechol + FAD + H2O
poor substrate for isozyme PheA1(1)
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-
?
4-chlorocatechol + FAD + H2O
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-
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?
4-chlorophenol + FADH2 + O2
4-chlorocatechol + FAD + H2O
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-
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?
catechol + FAD + H2O
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-
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?
phenol + FADH2 + O2
catechol + FAD + H2O
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?
phenol + FADH2 + O2
catechol + FAD + H2O
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?
phenol + FADH2 + O2
catechol + FAD + H2O
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a two-component enzyme system: the smaller flavin reductase PheA2 component catalyzes the NADH-dependent reduction of free FAD according to a ping pong bisubstrate-biproduct mechanism. The reduced FAD is then used by the larger oxygenase component PheA1 to hydroxylate phenols to the corresponding catechols
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-
?
phenol + FADH2 + O2
catechol + FAD + H2O
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a two-component enzyme system: the smaller flavin reductase PheA2 component catalyzes the NADH-dependent reduction of free FAD according to a ping pong bisubstrate-biproduct mechanism. The reduced FAD is then used by the larger oxygenase component PheA1 to hydroxylate phenols to the corresponding catechols
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?
phenol + FADH2 + O2
catechol + FAD + H2O
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?
phenol + FADH2 + O2
catechol + FAD + H2O
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?
phenol + FADH2 + O2
catechol + FAD + H2O
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?
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enzyme components PheA2 and PheA1 show no protein-protein interaction
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additional information
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enzyme components PheA2 and PheA1 show no protein-protein interaction
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-
?
additional information
?
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enzyme components PheA2 and PheA1 show no protein-protein interaction
-
-
?
additional information
?
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-
enzyme components PheA2 and PheA1 show no protein-protein interaction
-
-
?
additional information
?
-
enzyme components PheA2 and PheA1 show no protein-protein interaction
-
-
?
additional information
?
-
enzyme components PheA2 and PheA1 show no protein-protein interaction
-
-
?
additional information
?
-
substrate speccificities of the three isozymes, overview
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-
?
additional information
?
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substrate speccificities of the three isozymes, overview
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-
?