1.14.14.24: vitamin D 25-hydroxylase

This is an abbreviated version!
For detailed information about vitamin D 25-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.24

1.14.14.24

25-hydroxyvitamin

cyp27b1

cyp2j2

arachidonic

25-hydroxylation

epoxyeicosatrienoic

epoxygenase

rickets

d-related

male-specific

7-dehydrocholesterol

cholecalciferol

astemizole

ebastine

terfenadine

d-associated

medicine

1alpha-hydroxylation

Reaction

Synonyms

CYP2R1, CYP24A1, CYP2C11, CYP2D25, CYP2J3, CYP2R1, CYPIIJ3, Cytochrome P450 2C11, cytochrome P450 2J2, Cytochrome P450 2J3, cytochrome P450 2R1, EC 1.14.13.159, VDH, vitamin D 25-hydroxylase, vitamin D-25-hydroxylase, vitamin D2 25-hydroxylase, vitamin D3 25-hydroxylase, vitamin D3 hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.24 vitamin D 25-hydroxylase

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Results	in table
5	Activating Compound
8	AA Sequence
5	Application
13	Cloned(Commentary)
14	Cofactor
2	Crystallization (Commentary)
606	Disease/ Diagnostics
5	Expression
12	General Information
4	Inhibitors
22	KM Value [mM]
16	Localization
1	Metals/Ions
5	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
26	Organism
6	Pathway
3	pH Optimum
18	Protein Variants
2	Purification (Commentary)
1	Reaction
26	Reference
26	Source Tissue
1	Specific Activity [micromol/min/mg]
51	Substrates and Products (Substrate)
6	Subunits
36	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
13	Turnover Number [1/s]

KM Value

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KM Value on EC 1.14.14.24 - vitamin D 25-hydroxylase

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0.054

1alpha-hydroxycholecalciferol

Rattus norvegicus

pH 7.4, 37°C

717750

0.0042 - 0.018

1alpha-hydroxyvitamin D2

4 entries

0.0006 - 0.0113

1alpha-hydroxyvitamin D3

6 entries

0.0071

25-hydroxy-vitamin D3

Pseudonocardia autotrophica

C4B644

30°C, pH not specified in the publication

717180

0.001 - 0.0014

bufuralol

2 entries

0.00045 - 0.002

vitamin D2

2 entries

0.00079 - 0.032

vitamin D3

6 entries