1.14.14.24: vitamin D 25-hydroxylase

This is an abbreviated version!
For detailed information about vitamin D 25-hydroxylase, go to the full flat file.

Reaction

Synonyms

CYP2R1, CYP24A1, CYP2C11, CYP2D25, CYP2J3, CYP2R1, CYPIIJ3, Cytochrome P450 2C11, cytochrome P450 2J2, Cytochrome P450 2J3, cytochrome P450 2R1, EC 1.14.13.159, VDH, vitamin D 25-hydroxylase, vitamin D-25-hydroxylase, vitamin D2 25-hydroxylase, vitamin D3 25-hydroxylase, vitamin D3 hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.24 vitamin D 25-hydroxylase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
5	Activating Compound
8	AA Sequence
5	Application
13	Cloned(Commentary)
14	Cofactor
2	Crystallization (Commentary)
606	Disease/ Diagnostics
5	Expression
12	General Information
4	Inhibitors
22	KM Value [mM]
16	Localization
1	Metals/Ions
5	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
26	Organism
6	Pathway
3	pH Optimum
18	Protein Variants
2	Purification (Commentary)
1	Reaction
26	Reference
26	Source Tissue
1	Specific Activity [micromol/min/mg]
51	Substrates and Products (Substrate)
6	Subunits
36	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
13	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 1.14.14.24 - vitamin D 25-hydroxylase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

calciferol + O2 + [reduced NADPH-hemoprotein reductase]

25-hydroxy-vitamin D2 + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

Q6VVX0

enzyme CYP2R1 hydroxylates vitamin D2 at position C-25 position

735593

-

-

?

calciol + O2 + [reduced NADPH-hemoprotein reductase]

calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O

5 entries

calciol + O2 + [reduced NADPH-hemoprotein reductase]

calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

Q6VVX0

enzyme CYP2R1 hydroxylates vitamin D3 at position C-25 position

735593, 736222

-

-

?

calciol + O2 + [reduced NADPH-hemoprotein reductase]

calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

enzyme CYP2R1 hydroxylates vitamin D3 at position C-25 position

736222

-

-

?

calciol + O2 + [reduced NADPH-hemoprotein reductase]

calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

Q6VVX0

the microsomal enzyme CYP2R1 catalyzes C-25 hydroxylation of vitamin D3 to an active vitamin D receptor ligand in the liver and other organs

759328

-

-

?

calciol + O2 + [reduced NADPH-hemoprotein reductase]

calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O

Mus musculus

Q6VVW9

-

737160

-

-

?

calciol + O2 + [reduced NADPH-hemoprotein reductase]

calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O

Mus musculus C57BL/6

Q6VVW9

-

737160

-

-

?