1.14.14.29: 25/26-hydroxycholesterol 7alpha-hydroxylase

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For detailed information about 25/26-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Reaction

Synonyms

25-hydroxycholesterol 7alpha-hydroxylase, 25-hydroxycholesterol 7alpha-monooxygenase, 25-hydroxycholesterol-7alpha-hydroxylase, cholesterol 25-hydroxylase, Cyp39a1, CYP7B, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, CYPB1, cytochome P450 7B1, cytochrome P-450 oxysterol 7-alpha-hydroxylase, EC 1.14.13.100, EC 1.14.13.60, oxysterol 7 alpha-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol-7alpha-hydroxylase, Steroid hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.29 25/26-hydroxycholesterol 7alpha-hydroxylase

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Results	in table
1	Activating Compound
4	AA Sequence
1	Application
2	CAS Registry Number
6	Cloned(Commentary)
19	Cofactor
391	Disease/ Diagnostics
3	Expression
8	General Information
13	Inhibitors
2	Ki Value [mM]
7	KM Value [mM]
8	Localization
2	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
31	Organism
2	Pathway
8	Protein Variants
4	Reaction
3	Reaction Type
30	Reference
38	Source Tissue
46	Substrates and Products (Substrate)
2	Subunits
45	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

Cloned

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Cloned on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

2 entries

14 deletion mutants of the regulatory sequences of CYP7B1/Luc reporter gene are constructed for transfection assays. The constructs are transiently transfected into HepG2, NT1088, and HEK 293 cells

Homo sapiens

-

658818

CYP7B1 genotyping and screening for CYP7B1 mutations in a large cohort of 105 Italian HSP index patients, including 50 patients with a complicated phenotype and 55 with a pure form, overall mutation frequencies of CYP7B1, overview

Homo sapiens

O75881

711775

expression in 293/T cells

Homo sapiens

-

659660

from pCMV6 vector overexpressed in HEK-293 cells

Homo sapiens

O75881

702427

-

Mus musculus

-

659143

-

Homo sapiens

-

659143