1.14.15.15: cholestanetriol 26-monooxygenase

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For detailed information about cholestanetriol 26-monooxygenase, go to the full flat file.

Reaction

Synonyms

5beta-cholestane-3 alpha,7alpha,12alpha,26-tetrol dehydrogenase, 5beta-cholestane-3 alpha,7alpha,12alpha-triol-26-al oxidoreductase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 27-monooxygenase, 5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase, cholestanetriol 26-hydroxylase, cholestanetriol 27-hydroxylase, cholesterol C-26 hydroxylase, cholesterol hydroxylase, CYP125A4, CYP27, CYP27A, CYP27A1, cytochrome P-450 sterol 26-hydroxylase, cytochrome P-450A, cytochrome P450 125A4, cytochrome P450 27A, cytochrome P450c27, dehydrogenase, cholestanetetrol 26-, EC 1.1.1.161, EC 1.14.13.15, EC 1.2.1.40, hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol, More, oxygenase, cholestanetriol 26-mono-, P450 27A1, sterol 27-hydroxylase, TEHC-NAD oxidoreductase, vitamin D3 25-hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.15.15 cholestanetriol 26-monooxygenase

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Results	in table
3	Activating Compound
146	AA Sequence
3	Application
2	CAS Registry Number
13	Cloned(Commentary)
31	Cofactor
384	Disease/ Diagnostics
4	Expression
22	General Information
23	Inhibitors
2	kcat/KM [mM/s]
3	Ki Value [mM]
9	KM Value [mM]
30	Localization
1	Metals/Ions
5	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
40	Organism
4	Pathway
5	PDB ID
9	pH Optimum
2	pH Range
2	Posttranslational Modification
20	Protein Variants
12	Purification (Commentary)
5	Reaction
3	Reaction Type
40	Reference
69	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
73	Substrates and Products (Substrate)
4	Subunits
54	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

Expression

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Expression on EC 1.14.15.15 - cholestanetriol 26-monooxygenase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

astrocyte-restricted upregulation of Cyp27a1 due to to differential expression of transcriptional co-activators, increase of enzyme mRNA and protein levels in treated astrocytes is paralleled by transactivation of the proximal Cyp27a1 promoter in transfected astrocytes

Rattus norvegicus

-

705935

dexamethasone increases CYP27A1-mediated enzyme activity in HepG2 cells by CYP27A1 promoter activity more than 4fold as compared with untreated cells, mediated by glucocorticoid receptor alpha, glucocorticoid receptor alpha-antagonist mifepristone almost completely abolishes the dexamethasone-induced effect on the CYP27A1 promoter activity

Homo sapiens

-

702408

in vivo, in a high-salt administration experiment, male and female Dahl salt-sensitive rats become hypertensive after 4 weeks on a high-NaCl diet, their plasma marinobufagenin levels double, and adrenocortical CYP27A1 mRNA and protein increase 1.6fold and 2.0fold, respectively

Rattus norvegicus

P17178

735969

ritonavir increases CYP27 expression in in differentiated THP-1 macrophages, but not in undifferentiated monocytes

Homo sapiens

-

703582