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1.14.15.15: cholestanetriol 26-monooxygenase

This is an abbreviated version!
For detailed information about cholestanetriol 26-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.15

Reaction

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al
+ 2 reduced adrenodoxin + 2 H+ +
O2
=
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate
+ 2 oxidized adrenodoxin +
H2O

Synonyms

5beta-cholestane-3 alpha,7alpha,12alpha,26-tetrol dehydrogenase, 5beta-cholestane-3 alpha,7alpha,12alpha-triol-26-al oxidoreductase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 27-monooxygenase, 5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase, cholestanetriol 26-hydroxylase, cholestanetriol 27-hydroxylase, cholesterol C-26 hydroxylase, cholesterol hydroxylase, CYP125A4, CYP27, CYP27A, CYP27A1, cytochrome P-450 sterol 26-hydroxylase, cytochrome P-450A, cytochrome P450 125A4, cytochrome P450 27A, cytochrome P450c27, dehydrogenase, cholestanetetrol 26-, EC 1.1.1.161, EC 1.14.13.15, EC 1.2.1.40, hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol, More, oxygenase, cholestanetriol 26-mono-, P450 27A1, sterol 27-hydroxylase, TEHC-NAD oxidoreductase, vitamin D3 25-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.15 cholestanetriol 26-monooxygenase

Turnover Number

Turnover Number on EC 1.14.15.15 - cholestanetriol 26-monooxygenase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0183
(24S)-3beta-hydroxy-24-methyl-5alpha-cholesta-8(14),22-dien-15-one
-
pH 7.4, 37°C, kcat for the conversion of (24S)-3beta-hydroxy-methyl-5alpha-cholesta-8(14),22-dien-15-one into side chain oxygenated products
0.00233 - 0.0233
1alpha-hydroxyvitamin D3
0.073
3beta-hydroxy-5alpha-cholest-8(14)-en-15-one
-
pH 7.4, 37°C, kcat for the conversion of (24S)-3beta-hydroxy-methyl-5alpha-cholesta-8(14),22-dien-15-one into side chain oxygenated products
0.333 - 0.6
5beta-cholestane-3alpha,7alpha,12alpha-triol
0.217
5beta-cholestane-3alpha,7alpha-diol
-
-
0.0117
cholesterol
-
-