1.14.15.16: vitamin D3 24-hydroxylase

This is an abbreviated version!
For detailed information about vitamin D3 24-hydroxylase, go to the full flat file.

Word Map on EC 1.14.15.16

1.14.15.16

cyp24a1

parathyroid

1alpha-hydroxylase

rickets

24,25-dihydroxyvitamin

hypercalcemia

24-hydroxylation

retinoids

d-dependent

1alpha,25oh2d3

osteocalcin

vdres

d-deficient

1-hydroxylase

d-responsive

1,25-dihydroxycholecalciferol

hyperparathyroidism

ketoconazole

nephrocalcinosis

alopecia

vdr-mediated

hypophosphatemic

d-binding

1,25oh2d3-induced

extrarenal

hypercalciuria

cholecalciferol

25-hydroxycholecalciferol

calcemic

1alpha-ohase

alpha-hydroxyvitamin

calcidiol

d-resistant

d3-1alpha-hydroxylase

osteomalacia

d-replete

secosteroid

hvdrr

sodium-phosphate

medicine

Reaction

+ 2 reduced adrenodoxin + 2 H+ +

+ 2 oxidized adrenodoxin +

Synonyms

1,25-(OH)2D3-24-hydroxylase, 1,25-dihydroxyvitamin D3 24-hydroxylase, 1alpha,25-dihydroxyvitamin D3 24-hydroxylase, 24-hydroxylase, 24-OHase, 24OHase, 25-hydroxyvitamin D-24-hydroxylase, 25-hydroxyvitamin D3-24-hydroxylase, 25-OH-D3-24-hydroxylase, CYP24A1, cytochrome P450 24A1, EC 1.14.13.126, P450cc24, vitamin D 24-hydroxylase, vitamin D-24-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.15.16 vitamin D3 24-hydroxylase

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Results	in table
4	Activating Compound
6	AA Sequence
1	Application
14	Cloned(Commentary)
41	Cofactor
463	Disease/ Diagnostics
9	Expression
14	General Information
16	IC50 Value
44	Inhibitors
13	kcat/KM [mM/s]
24	Ki Value [mM]
21	KM Value [mM]
10	Localization
1	Metals/Ions
6	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
32	Organism
2	Pathway
2	pH Optimum
28	Protein Variants
5	Purification (Commentary)
2	Reaction
2	Reaction Type
32	Reference
36	Source Tissue
105	Substrates and Products (Substrate)
2	Subunits
57	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
13	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.14.15.16 - vitamin D3 24-hydroxylase

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1alpha,25-dihydroxyvitamin D3

Mus musculus

renal 24-hydroxylase is significantly stimulated by 1alpha,25-dihydroxyvitamin D3 treatment in both normal and Hyp mice. In normal mice, 1alpha,25-dihydroxyvitamin D3 treatment is more effective than calcium in turning on 24-hydroxylase activity. In Hyp mice, treatment with calcium plus 1alpha,25-dihydroxyvitamin D3 results in a greater increase in 24-hydroxylase than treatment with either agent alone. 24-hydroxylase is 3fold, and 8fold greater in Hyp mice relative to normal treated with 1alpha,25-dihydroxyvitamin D3, and calcium plus 1alpha,25-dihydroxyvitamin D3, respectively

714835

adrenodoxin

Homo sapiens

required for activity of the recombinant enzyme

714138

adrenodoxin reductase

Homo sapiens

required for activity of the recombinant enzyme

714138

calcitriol

Rattus norvegicus

calcitriol increases its own degradation in renal failure by increasing the enzymatic activity of 24-hydroxylase

716071