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(24R),25-dihydroxycholecalciferol + NADPH + O2
1alpha,24,25-trihydroxycholecalciferol + NADP+ + H2O
25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
25-hydroxyvitamin D2 + NADPH + H+ + O2
1,25-dihydroxyvitamin D2 + NADP+ + H2O
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25-hydroxyvitamin D3 + H+ + O2
25-hydroxyvitamin D3 + H2O
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25-hydroxyvitamin D3 + NADPH + H+ + O2
1,25-dihydroxyvitamin D3 + NADP+ + H2O
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25-hydroxyvitamin D3 + NADPH + O2
1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
cholecalciferol + NADPH + O2
25-hydroxyvitamin D3 + NADP+ + H2O
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additional information
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(24R),25-dihydroxycholecalciferol + NADPH + O2
1alpha,24,25-trihydroxycholecalciferol + NADP+ + H2O
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(24R),25-dihydroxycholecalciferol + NADPH + O2
1alpha,24,25-trihydroxycholecalciferol + NADP+ + H2O
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25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
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energy-dependent transhydrogenation is of importance
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25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
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25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
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central role in calcium regulation
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25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
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25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
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recombinant in E. coli
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25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
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enzyme activity is correlated with phosphate content in serum
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25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
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central role in calcium regulation
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25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
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central role in calcium regulation
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25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
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recombinant in E. coli
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25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
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recombinant in E. coli
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25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
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central role in calcium regulation
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25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
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central role in calcium regulation
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25-hydroxycholecalciferol + NADPH + O2
calcitriol + NADP+ + H2O
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25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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1,25(OH)2D3 is an antiproliferative agent that may inhibit proliferation of breast cancer cells
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25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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1,25-dihydroxyvitamin D3 (1,25-D3) is a key determinant of calcium homeostasis, cell proliferation and differentiation, calcium and vitamin D might have a protective function against colorectal tumor pathogenesis, overview
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25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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bioactivation
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25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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extra-renal functions of 1alpha-hydroxylase in vitamin D physiology, regulation, overview
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25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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regulation of enzyme expression in kidney proximal tubules, overview
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25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
substrate activation by the rate-limiting enzyme 1alpha-hydroxylase in cells of the immune system under control of immune stimuli, such as interferon-gamma, in pathological situations, such as sarcoidosis, this can lead to systemic excess of 1,25(OH)2D3 and hypercalcemia
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25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
the enzyme hydroxylates the major circulating form of vitamin D to the active systemic hormone 1,25(OH)2D3, local production of 1,25(OH)2D3 appears to occur also at other sites where 1alpha-hydroxylase is expressed for autocrine/paracrine regulation, overview
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25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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the enzyme is involved in the vitamin D signaling pathway in colonic epithelial cell differentiation by butyrate, mechanism, overview
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25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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the enzyme is responsible for final hydroxylation of vitamin D3, in response to IFNgamma and CD14/TLR4 activation
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25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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deficiency of the enzyme, due to mutation of residues Q65 and T409, in substrate binding causes vitamin D-dependent rickets type 1, overview
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25-hydroxyvitamin D + NADPH + O2
1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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25-hydroxyvitamin D3 + NADPH + O2
1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
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final step of the activation of vitamin D
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25-hydroxyvitamin D3 + NADPH + O2
1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
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final step of the activation of vitamin D, involved in tumor suppressing activity due to the tumor growth inhibiting effect of 1alpha,25-dihydroxyvitamin D3
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25-hydroxyvitamin D3 + NADPH + O2
1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
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final step of the activation of vitamin D
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25-hydroxyvitamin D3 + NADPH + O2
1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
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additional information
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25(OH)D3 therapy is useful for colorectal cancer chemoprevention but provitamin D is less likely to be useful for colorectal cancer chemotherapy, overview
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additional information
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both butyrate and 1alpha-25(OH)2D3 stimulate differentiation of Caco-2 cells, while 25(OH)2D3 has no impact on cell differentiation
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additional information
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colonic and renal vitamin D hydroxylases are regulated independently
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additional information
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functional analysis of vitamin D metabolism in cancer, locally synthesized 1,25(OH)2D3 may be inefficient in preventing tumor progression, mechanism, overview
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additional information
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immune regulation of the enzyme in monocytes, cross-talk between the JAK-STAT, the NFkappaB, and the p38 MAPK pathways is necessary, and direct binding of C/EBPbeta to its recognition sites in the promoter of the 1alpha-hydroxylase gene is a prerequisite, overview
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additional information
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the enzyme is involved in local production of 1alpha,25-dihydroxyvitamin D, i.e. 1alpha,25(OH)2D3, in tumorigenesis
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additional information
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the 1alpha-OHase gene is a tumor suppressor gene responsible for the normal regulation of prostate cell growth
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additional information
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PTH and PTHrP are involved in enzyme regulation, PTH is the major protein hormone regulating calcium homeostasis, PTHrP is a PTH-like factor responsible for humoral hypercalcemia of malignancy, both peptides are required to achieve normal fetal skeletal morphogenesis, overview
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additional information
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Vdh, a cytochrome P450 enzyme, is responsible for the biocatalytic conversion of vitamin D3, catalyzing the two-step hydroxylation of VD3, i.e. the conversion of VD3 to 25-hydroxyvitamin D3 (25(OH)VD3) and then of 25(OH)VD3 to 1alpha,25(OH)2VD3, a hormonal form of VD3. Anti-parallel substrate binding modes enable sequential hydroxylation, structure-function analysis, overview
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