1.14.15.4: steroid 11beta-monooxygenase

This is an abbreviated version!
For detailed information about steroid 11beta-monooxygenase, go to the full flat file.

Reaction

Synonyms

11
-hydroxylase, 11 beta-hydroxylase, 11-beta hydroxylase, 11-beta-hydroxylase, 11-hydroxylase, 11beta hydroxylase, 11beta-hydroxylase, ALDOS, Aldosterone synthase, Aldosterone-synthesizing enzyme, C450XIB2, CYP11B1, CYP11B2, cyp11beta, CYPXIB, CYPXIB1, CYPXIB2, CYPXIB3, cytochrome 11beta-hydroxylase, cytochrome P-45011-beta, cytochrome P450 11B1, cytochrome P450 11B2, cytochrome P450 11beta-hydroxylase, cytochrome P45011beta, cytochrome P45011beta-hydroxylase, EC 1.14.1.6, EC 1.99.1.7, P-450(11 beta,aldo), P-450Aldo, P-450c11, P-450C18, P-450XIB1, P450 11beta-hydroxylase, P450(11 beta)-DS, P45011beta, P450C11, Steroid 11-beta-hydroxylase, steroid 11-hydroxylase, steroid 11beta-hydroxylase, steroid 11beta-monooxygenase, steroid 11beta/18-hydroxylase, Steroid 18-hydroxylase, steroid-11beta-hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.15.4 steroid 11beta-monooxygenase

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Results	in table
14	Activating Compound
138	AA Sequence
9	Application
1	CAS Registry Number
36	Cloned(Commentary)
53	Cofactor
1	Crystallization (Commentary)
4812	Disease/ Diagnostics
2	Expression
16	General Information
15	General Stability
213	IC50 Value
224	Inhibitors
4	Ki Value [mM]
27	KM Value [mM]
39	Localization
3	Metals/Ions
22	Molecular Weight [Da]
62	Natural Substrates/ Products (Substrates)
83	Organism
7	Pathway
60	PDB ID
26	pH Optimum
1	pH Range
35	Protein Variants
21	Purification (Commentary)
15	Reaction
4	Reaction Type
80	Reference
104	Source Tissue
31	Specific Activity [micromol/min/mg]
20	Storage Stability
138	Substrates and Products (Substrate)
20	Subunits
139	Synonyms
1	Systematic Name
26	Temperature Optimum [°C]
2	Temperature Range [°C]
7	Temperature Stability [°C]
11	Turnover Number [1/s]

Reference

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Reference on EC 1.14.15.4 - steroid 11beta-monooxygenase

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

285386

Tomkins, G.M.; Michael, P.J.; Curran, J.F.

Studies on the nature of steroid 11-beta hydroxylation

Biochim. Biophys. Acta

23

655-656

1957

Bos taurus, Oryctolagus cuniculus

13426185

brenda

285387

Grant, J.K.; Brownie, A.C.

The role of fumarate and TPN in steroid enzymic 11beta-hydroxylation

Biochim. Biophys. Acta

18

433-434

1955

Bos taurus

13276417

brenda

285388

Zuidweg, M.H.J.

Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata

Biochim. Biophys. Acta

152

144-158

1968

Curvularia lunata

4967077

brenda

285389

Watanuki, M.; Tilley, B.E.; Hall, P.F.

Purification and properties of cytochrome p-450 (11beta- and 18-hydroxylase) from bovine adrenocortical mitochondria

Biochim. Biophys. Acta

483

236-247

1977

Bos taurus

889836

brenda

285390

Watanuki, M.; Tilley, B.E.; Hall, P.F.

Cytochrome P-450 for 11beta- and 18-hydroxylase activities of bovine adrenocortical mitochondria: one enzyme or two?

Biochemistry

17

127-130

1978

Bos taurus

412519

brenda

285391

Sato, H.; Ashida, N.; Suhara, K.; Itagaki, E.; Takemori, S.; Katagiri, M.

Properties of an adrenal cytochrome P-450 (P-45011beta) for the hydroxylations of corticosteroids

Arch. Biochem. Biophys.

190

307-314

1978

Bos taurus

708075

brenda

285392

Ogishima, T.; Mitani, F.; Ishimura, Y.

Isolation of aldosterone synthase cytochrome P-450 from zona glomerulosa mitochondria of rat adrenal cortex

J. Biol. Chem.

264

10935-10938

1989

Rattus norvegicus

2738055

brenda

285393

Cooper, D.Y.; Schleyer, H.; Levin, S.S.; Rosenthal, O.

Studies on the partially purified heme protein P-450 from the adrenal cortex

Ann. N. Y. Acad. Sci.

212

227-242

1973

Bos taurus

4155923

brenda

285394

Lombardo, A.; Defaye, G.; Guidicelli, C.; Monnier, N.; Chambaz, E.M.

Integration of purified adrenocortical cytochrome P-45011beta into phospholipid vesicles

Biochem. Biophys. Res. Commun.

104

1638-1645

1982

Bos taurus

6978716

brenda

285395

Yanigabashi, K.; Haniu, M.; Shively, J.E.; Shen, W.H.; Hall, P.

The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11beta-, 18-hydroxylation, and aldehyde synthesis

J. Biol. Chem.

261

3556-3562

1986

Bos taurus, Sus scrofa

3485096

brenda

285396

Ogishima, T.; Mitani, F.; Ishimura, Y

Isolation of two distinct cytochromes P-45011beta with aldosterone synthase activity from bovine adrenocortical mitochondria

J. Biochem.

105

497-499

1989

Bos taurus

2788159

brenda

285397

Lauber, M.; Muller, J.

Purification and characterization of two distinct forms of rat adrenal cytochrome P450(11) beta: functional and structural aspects

Arch. Biochem. Biophys.

274

109-119

1989

Rattus norvegicus

2789017

brenda

285398

Seybert, D.

Lipid regulation of bovine cytochrome P45011beta activity

Arch. Biochem. Biophys.

279

188-194

1990

Bos taurus

2337351

brenda

285399

Tsubaki, M.; Ichikawa, Y.; Fujimoto, Y.; Yu, N.T.; Hori, H.

Active site of bovine adrenocortical cytochrome P-45011beta studied by resonance Raman and electron paramagnetic resonance spectroscopies: distinction from cytochrome P-450scc

Biochemistry

29

8805-8812

1990

Bos taurus

2176837

brenda

285400

Yanigabashi, K.; Kobayashi, Y.; Hall, P.F.

Ascorbate as a source of reducing equivalents for the synthesis of aldosterone

Biochem. Biophys. Res. Commun.

170

1256-1262

1990

Bos taurus

2390091

brenda

285401

Boon, W.C.; Roche, P.J.; Butkus, A.; McDougall, J.G.; Jeyaseelan, K.; Coghlan, J.P.

Functional and expression analysis of ovine steroid 11beta-hydroxylase (cytochrome P 45011beta)

Endocr. Res.

23

325-347

1997

Ovis aries

9430822

brenda

285402

Delorme, C.; Piffeteau, A.; Viger, A.; Marquet, A.

Inhibition of bovine cytochrome P-45011beta by 18-unsaturated progesterone derivatives

Eur. J. Biochem.

232

247-256

1995

Bos taurus

7556158

brenda

285403

Delorme, C.; Piffeteau, A.; Sobrio, F.; Marquet, A.

Mechanism-based inactivation of bovine cytochrome P-45011beta by 18-unsaturated progesterone derivatives

Eur. J. Biochem.

248

252-260

1997

Bos taurus

9310386

brenda

285404

Davioud, E.; Piffeteau, A.; Delorme, C.; Coustal, S.; Marquet, A.

18-Vinyldeoxycorticosterone: a potent inhibitor of the bovine cytochrome P-45011beta

Bioorg. Med. Chem.

6

1781-1788

1998

Bos taurus

9839008

brenda

285405

Ohnishi, T.; Miura, S.; Ichikawa, Y.

Photoaffinity labeling of cytochrome P-45011beta with methyltrienolone as a probe for the substrate binding region

Biochim. Biophys. Acta

1161

257-264

1993

Bos taurus

8431474

brenda

285406

Nagamine, S.; Horisaka, E.; Fukuyama, Y.; Maetani, K.; Matsuzawa, R.; Iwakawa, S.; Asada, S.

Stereoselective reductive metabolism of metyrapone and inhibitory activity of metyrapone metabolites, metyrapol enantiomers, on steroid 11beta-hydroxylase in the rat

Biol. Pharm. Bull.

20

188-192

1997

Rattus norvegicus

9057984

brenda

285407

Denner, K.; Vogel, R.; Schmalix, W.; Doehmer, J.; Bernhardt, R.

Cloning and stable expression of the human mitochondrial cytochrome P45011B1 cDNA in V79 Chinese hamster cells and their application for testing of potential inhibitors

Pharmacogenetics

5

89-96

1995

Homo sapiens

7663533

brenda

285408

Nonaka, Y.; Takemori, H.; Halder, S.K.; Sun, T.; Ohta, M.; Hatano, O.; Takakusu, A.; Okamoto, M.

Frog cytochrome P-450 (11beta,aldo), a single enzyme involved in the final steps of glucocorticoid and mineralocorticoid biosynthesis

Eur. J. Biochem.

229

249-256

1995

Lithobates catesbeianus

7744036

brenda

285409

Suzuki, K.; Sanga, K.i.; Chikaoka, Y.; Itagaki, E.

Purification and properties of cytochrome P-450 (P-450lun) catalyzing steroid 11beta-hydroxylation in Curvularia lunata

Biochim. Biophys. Acta

1203

215-223

1993

Curvularia lunata

8268203

brenda

285410

Zhou, M.Y.; Gomez-Sanchez, E.P.; Foecking, M.F.; Gomez-Sanchez, C.E.

Cloning and expression of the rat adrenal cytochrome P-450 11B3 (CYP11B3) enzyme cDNA: preferential 18-hydroxylation over 11beta-hydroxylation of DOC

Mol. Cell. Endocrinol.

114

137-145

1995

Rattus norvegicus

8674838

brenda

285411

Kuhn-Velten, W.N.

Norharman (beta-carboline) as a potent inhibitory ligand for steroidogenic cytochromes P450 (CYP11 and CYP17)

Eur. J. Pharmacol.

250

R1-3

1993

Rattus norvegicus

8119304

brenda

655347

Wang, G.M.; Ge, R.S.; Latif, S.A.; Morris, D.J.; Hardy, M.P.

Expression of 11beta-hydroxylase in rat Leydig cells

Endocrinology

143

621-626

2002

Rattus norvegicus

11796518

brenda

657511

Lloyd-MacGilp, S.A.; Torielli, L.; Bechtel, S.; Tripodi, G.; Gomez-Sanchez, C.E.; Zagato, L.; Bernhardt, R.; Kenyon, C.J.

Mutations in aldosterone synthase gene of Milan hypertensive rats: phenotypic consequences

Am. J. Physiol.

282

E608-617

2002

Rattus norvegicus

11832364

brenda

659682

Ulmschneider, S.; Muller-Vieira, U.; Klein, C.D.; Antes, I.; Lengauer, T.; Hartmann, R.W.

Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase

J. Med. Chem.

48

1563-1575

2005

Homo sapiens

15743198

brenda

659683

Ulmschneider, S.; Muller-Vieira, U.; Mitrenga, M.; Hartmann, R.W.; Oberwinkler-Marchais, S.; Klein, C.D.; Bureik, M.; Bernhardt, R.; Antes, I.; Lengauer, T.

Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase

J. Med. Chem.

48

1796-1805

2005

Homo sapiens

15771425

brenda

659746

MacKenzie, S.M.; Lai, M.; Clark, C.J.; Fraser, R.; Gomez-Sanchez, C.E.; Seckl, J.R.; Connell, J.M.; Davies, E.

11beta-hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons

J. Mol. Endocrinol.

29

319-325

2002

Rattus norvegicus

12459034

brenda

659974

Kusakabe, M.; Kobayashi, T.; Todo, T.; Mark Lokman, P.; Nagahama, Y.; Young, G.

Molecular cloning and expression during spermatogenesis of a cDNA encoding testicular 11beta-hydroxylase (P45011beta) in rainbow trout (Oncorhynchus mykiss)

Mol. Reprod. Dev.

62

456-469

2002

Oncorhynchus mykiss

12112578

brenda

672590

Ulmschneider, S.; Negri, M.; Voets, M.; Hartmann, R.W.

Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2)

Bioorg. Med. Chem. Lett.

16

25-30

2006

Homo sapiens

16246562

brenda

673258

Lajer, M.; Schjoedt, K.J.; Jacobsen, P.; Tarnow, L.; Parving, H.H.

Aldosterone synthase (CYP11B2) -344T/C polymorphism is not associated with the initiation and progression of diabetic nephropathy in Caucasian Type 1 diabetic patients

Diabet. Med.

23

675-680

2006

Homo sapiens

16759311

brenda

673345

Ye, P.; Kenyon, C.J.; MacKenzie, S.M.; Jong, A.S.; Miller, C.; Gray, G.A.; Wallace, A.; Ryding, A.S.; Mullins, J.J.; McBride, M.W.; Graham, D.; Fraser, R.; Connell, J.M.; Davies, E.

The aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart

Endocrinology

146

5287-5293

2005

Rattus norvegicus

16179417

brenda

673348

Lin, T.C.; Chien, S.C.; Hsu, P.C.; Li, L.A.

Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation

Endocrinology

147

1536-1544

2006

Homo sapiens

16396990

brenda

673923

Kuribayashi, I.; Nomoto, S.; Massa, G.; Oostdijk, W.; Wit, J.M.; Wolffenbuttel, B.H.; Shizuta, Y.; Honke, K.

Steroid 11-beta-hydroxylase deficiency caused by compound heterozygosity for a novel mutation, p.G314R, in one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele

Horm. Res.

63

284-293

2005

Homo sapiens (P15538)

16024935

brenda

673925

Peters, C.J.; Nugent, T.; Perry, L.A.; Davies, K.; Morel, Y.; Drake, W.M.; Savage, M.O.; Johnston, L.B.

Cosegregation of a novel homozygous CYP11B1 mutation with the phenotype of non-classical congenital adrenal hyperplasia in a consanguineous family

Horm. Res.

67

189-193

2007

Homo sapiens

17124386

brenda

673954

Barr, M.; MacKenzie, S.M.; Friel, E.C.; Holloway, C.D.; Wilkinson, D.M.; Brain, N.J.; Ingram, M.C.; Fraser, R.; Brown, M.; Samani, N.J.; Caulfield, M.; Munroe, P.B.; Farrall, M.; Webster, J.; Clayton, D.; Dominiczak, A.F.; Connell, J.M.; Davies, E.

Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency

Hypertension

49

113-119

2006

Homo sapiens

17075029

brenda

675052

Keavney, B.; Mayosi, B.; Gaukrodger, N.; Imrie, H.; Baker, M.; Fraser, R.; Ingram, M.; Watkins, H.; Farrall, M.; Davies, E.; Connell, J.

Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion

J. Clin. Endocrinol. Metab.

90

1072-1077

2005

Homo sapiens

15522937

brenda

675053

Ganapathipillai, S.; Laval, G.; Hoffmann, I.S.; Castejon, A.M.; Nicod, J.; Dick, B.; Frey, F.J.; Frey, B.M.; Cubeddu, L.X.; Ferrari, P.

CYP11B2-CYP11B1 haplotypes associated with decreased 11beta-hydroxylase activity

J. Clin. Endocrinol. Metab.

90

1220-1225

2005

Homo sapiens

15507509

brenda

675054

Krone, N.; Riepe, F.G.; Goetze, D.; Korsch, E.; Rister, M.; Commentz, J.; Partsch, C.J.; Groetzinger, J.; Peter, M.; Sippell, W.G.

Congenital adrenal hyperplasia due to 11-hydroxylase deficiency: functional characterization of two novel point mutations and a three-base pair deletion in the CYP11B1 gene

J. Clin. Endocrinol. Metab.

90

3724-3730

2005

Homo sapiens

15755848

brenda

675055

Paperna, T.; Gershoni-Baruch, R.; Badarneh, K.; Kasinetz, L.; Hochberg, Z.

Mutations in CYP11B1 and congenital adrenal hyperplasia in Moroccan Jews

J. Clin. Endocrinol. Metab.

90

5463-5465

2005

Homo sapiens

16030166

brenda

675058

Imrie, H.; Freel, M.; Mayosi, B.M.; Davies, E.; Fraser, R.; Ingram, M.; Cordell, H.J.; Farrall, M.; Avery, P.J.; Watkins, H.; Keavney, B.; Connell, J.M.

Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene

J. Clin. Endocrinol. Metab.

91

5051-5056

2006

Homo sapiens

16984984

brenda

675295

Voets, M.; Antes, I.; Scherer, C.; Mueller-Vieira, U.; Biemel, K.; Marchais-Oberwinkler, S.; Hartmann, R.W.

Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis

J. Med. Chem.

49

2222-2231

2006

Homo sapiens

16570918

brenda

675684

Mueller-Vieira, U.; Angotti, M.; Hartmann, R.W.

The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors

J. Steroid Biochem. Mol. Biol.

96

259-270

2005

Homo sapiens

15985365

brenda

686170

Freel, E.M.; Ingram, M.; Wallace, A.M.; White, A.; Fraser, R.; Davies, E.; Connell, J.M.

Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects

Clin. Endocrinol. (Oxf.)

68

700-706

2008

Homo sapiens

17980006

brenda

686286

Wang, X.G.; Orban, L.

Anti-Muellerian hormone and 11 beta-hydroxylase show reciprocal expression to that of aromatase in the transforming gonad of zebrafish males

Dev. Dyn.

236

1329-1338

2007

Danio rerio (A1XRK1), Danio rerio

17393497

brenda

686458

Chen, K.; Tong, W.; Wei, D.; Jiang, W.

The 11beta-hydroxylation of 16,17alpha-epoxyprogesterone and the purification of the 11beta-hydroxylase from Absidia coerulea IBL02

Enzyme Microb. Technol.

41

71-79

2007

Absidia caerulea, Absidia caerulea IBL02

-

brenda

686714

Zoellner, A.; Kagawa, N.; Waterman, M.R.; Nonaka, Y.; Takio, K.; Shiro, Y.; Hannemann, F.; Bernhardt, R.

Purification and functional characterization of human 11beta hydroxylase expressed in Escherichia coli

FEBS J.

275

799-810

2008

Homo sapiens

18215163

brenda

686928

Socorro, S.; Martins, R.S.; Deloffre, L.; Mylonas, C.C.; Canario, A.V.

A cDNA for European sea bass (Dicentrarchus labrax) 11beta-hydroxylase: gene expression during the thermosensitive period and gonadogenesis

Gen. Comp. Endocrinol.

150

164-173

2007

Dicentrarchus labrax

16962121

brenda

687019

Simm, P.J.; Zacharin, M.R.

Successful pregnancy in a patient with severe 11-beta-hydroxylase deficiency and novel mutations in CYP11B1 gene

Horm. Res.

68

294-297

2007

Homo sapiens

17726333

brenda

687020

Peter, M.; Janzen, N.; Sander, S.; Korsch, E.; Riepe, F.G.; Sander, J.

A case of 11beta-hydroxylase deficiency detected in a newborn screening program by second-tier LC-MS/MS

Horm. Res.

69

253-256

2008

Homo sapiens

18204274

brenda

687021

Riedl, S.; Nguyen, H.H.; Clausmeyer, S.; Schulze, E.; Waldhauser, F.; Bernhardt, R.

A homozygous L299P mutation in the CYP11B1 gene leads to complete virilization in 46,XX individuals with 11-beta-hydroxylase deficiency

Horm. Res.

70

145-149

2008

Homo sapiens

18663314

brenda

688009

Ye, P.; Kenyon, C.J.; Mackenzie, S.M.; Nichol, K.; Seckl, J.R.; Fraser, R.; Connell, J.M.; Davies, E.

Effects of ACTH, dexamethasone, and adrenalectomy on 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat central nervous system

J. Endocrinol.

196

305-311

2008

Rattus norvegicus

18252953

brenda

688012

Cingoez, S.; Ozkan, B.; Doeneray, H.; Sakizli, M.

Familial pericentric inversion chromosome 3 and R448C mutation of CYP11B1 gene in Turkish kindred with 11beta-hydroxylase deficiency

J. Endocrinol. Invest.

30

285-291

2007

Homo sapiens

17556864

brenda

688587

Tonetto-Fernandes, V.; Lemos-Marini, S.H.; De Mello, M.P.; Ribeiro-Neto, L.M.; Kater, C.E.

21-hydroxylase deficiency transiently mimicking combined 21- and 11beta-hydroxylase deficiency

J. Pediatr. Endocrinol. Metab.

21

487-494

2008

Homo sapiens

18655532

brenda

688588

Atabek, M.E.; Pirgon, O.; Sert, A.

Hypokalemic rhabdomyolysis in a child with 11-hydroxylase deficiency

J. Pediatr. Endocrinol. Metab.

21

93-96

2008

Homo sapiens

18404978

brenda

690171

Nimkarn, S.; New, M.I.

Steroid 11beta-hydroxylase deficiency congenital adrenal hyperplasia

Trends Endocrinol. Metab.

19

96-99

2008

Homo sapiens

18294861

brenda

690201

Zhao, L.Q.; Han, S.; Tian, H.M.

Progress in molecular-genetic studies on congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency

World J. Pediatr.

4

85-90

2008

Homo sapiens

18661760

brenda

690218

Miura, S.; Horiguchi, R.; Nakamura, M.

Immunohistochemical evidence for 11beta-hydroxylase (P45011beta) and androgen production in the gonad during sex differentiation and in adults in the protandrous anemonefish Amphiprion clarkii

Zool. Sci.

25

212-219

2008

Amphiprion clarkii

18533753

brenda

695555

LaSala, D.; Shibanaka, Y.; Jeng, A.Y.

Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors

Anal. Biochem.

394

56-61

2009

Homo sapiens (P15538), Homo sapiens (P19099), Homo sapiens

19622340

brenda

696010

Imachi, H.; Murao, K.; Cao, W.M.; Muraoka, T.; Nishiuchi, T.; Dobashi, H.; Hosomi, N.; Iwama, H.; Ishida, T.

The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene

Biochem. Biophys. Res. Commun.

376

531-535

2008

Mus musculus

18801336

brenda

698017

Liu, J.F.; Guiguen, Y.; Liu, S.J.

Aromatase (P450arom) and 11beta-hydroxylase (P45011beta) genes are differentially expressed during the sex change process of the protogynous rice field eel, Monopterus albus

Fish Physiol. Biochem.

35

511-518

2009

Monopterus albus (Q2I128), Monopterus albus

18807204

brenda

698085

Zhang, W.L.; Zhou, L.Y.; Senthilkumaran, B.; Huang, B.F.; Sudhakumari, C.C.; Kobayashi, T.; Nagahama, Y.; Wang, D.S.

Molecular cloning of two isoforms of 11beta-hydroxylase and their expressions in the Nile tilapia, Oreochromis niloticus

Gen. Comp. Endocrinol.

165

34-41

2010

Oreochromis niloticus

19500584

brenda

711420

Adams, C.M.; Hu, C.W.; Jeng, A.Y.; Karki, R.; Ksander, G.; Lasala, D.; Leung-Chu, J.; Liang, G.; Liu, Q.; Meredith, E.; Rao, C.; Rigel, D.F.; Shi, J.; Smith, S.; Springer, C.; Zhang, C.

The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase

Bioorg. Med. Chem. Lett.

20

4324-4327

2010

Homo sapiens

20615692

brenda

711434

Zimmer, C.; Hafner, M.; Zender, M.; Ammann, D.; Hartmann, R.W.; Vock, C.A.

N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2)

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2011

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Parajes, S.; Loidi, L.; Reisch, N.; Dhir, V.; Rose, I.T.; Hampel, R.; Quinkler, M.; Conway, G.S.; Castro-Feijoo, L.; Araujo-Vilar, D.; Pombo, M.; Dominguez, F.; Williams, E.L.; Cole, T.R.; Kirk, J.M.; Kaminsky, E.; Rumsby, G.; Arlt, W.; Krone, N.

Functional consequences of seven novel mutations in the CYP11B1 gene: four mutations associated with nonclassic and three mutations causing classic 11beta-hydroxylase deficiency

J. Clin. Endocrinol. Metab.

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779-788

2010

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Roumen, L.; Peeters, J.W.; Emmen, J.M.; Beugels, I.P.; Custers, E.M.; de Gooyer, M.; Plate, R.; Pieterse, K.; Hilbers, P.A.; Smits, J.F.; Vekemans, J.A.; Leysen, D.; Ottenheijm, H.C.; Janssen, H.M.; Hermans, J.J.

Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2)

J. Med. Chem.

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2010

Homo sapiens

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Lucas, S.; Negri, M.; Heim, R.; Zimmer, C.; Hartmann, R.W.

Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives

J. Med. Chem.

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2011

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Saha, S.; Bornstein, S.R.; Graessler, J.; Kopprasch, S.

Very-low-density lipoprotein mediates transcriptional regulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways

Cell Tissue Res.

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2012

Homo sapiens

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Hobler, A.; Kagawa, N.; Hutter, M.C.; Hartmann, M.F.; Wudy, S.A.; Hannemann, F.; Bernhardt, R.

Human aldosterone synthase: recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level

J. Steroid Biochem. Mol. Biol.

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2012

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Strushkevich, N.; Gilep, A.A.; Shen, L.; Arrowsmith, C.H.; Edwards, A.M.; Usanov, S.A.; Park, H.W.

Structural insights into aldosterone synthase substrate specificity and targeted inhibition

Mol. Endocrinol.

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315-324

2013

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Adams, B.P.; Bose, H.S.

Alteration in accumulated aldosterone synthesis as a result of N-terminal cleavage of aldosterone synthase

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2012

Homo sapiens

22184340

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Vecchiola, A.; Lagos, C.F.; Fuentes, C.A.; Allende, F.; Campino, C.; Valdivia, C.; Tapia-Castillo, A.; Ogishima, T.; Mukai, K.; Owen, G.; Solari, S.; Carvajal, C.A.; Fardella, C.E.

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro

Reprod. Biol. Endocrinol.

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76

2013

Homo sapiens

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Neunzig, J.; Khatri, Y.; Bernhardt, R.

The impact of the clinical CYP11B2 mutation V386A strongly depends on the enzymes genetic background

Endocr. J.

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2017

Homo sapiens (P19099), Homo sapiens

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van Rooyen, D.; Gent, R.; Barnard, L.; Swart, A.C.

The in vitro metabolism of 11beta-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway

J. Steroid Biochem. Mol. Biol.

178

203-212

2018

Homo sapiens (P15538), Homo sapiens (P19099), Homo sapiens

29277707

brenda

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