1.14.15.4: steroid 11beta-monooxygenase

This is an abbreviated version!
For detailed information about steroid 11beta-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.4

1.14.15.4

hypertension

cortisol

adrenocortical

steroidogenic

corticosterone

angiotensin

hyperplasia

acth

zona

glucocorticoid

steroidogenesis

mineralocorticoid

glomerulosa

adenoma

21-hydroxylase

renin

11-deoxycortisol

deoxycorticosterone

fasciculata

metyrapone

11-deoxycorticosterone

beta-hydroxysteroid

pregnenolone

angiotensinogen

cushing

cyp11a1

virilization

androstenedione

cyp21

spironolactone

18-hydroxycorticosterone

p450scc

adrenodoxin

17-hydroxyprogesterone

hirsutism

beta-hydroxylation

atp1a1

acth-stimulated

17alpha-hydroxylase

cortisol-producing

etomidate

hsd3b2

hypokalemia

medicine

trilostane

apccs

salt-wasting

11-ketotestosterone

low-renin

drug development

liddle

extra-adrenal

analysis

Reaction

+ 2 reduced adrenodoxin +

+ 2 H+ =

+ 2 oxidized adrenodoxin +

Synonyms

11-hydroxylase, 11 beta-hydroxylase, 11-beta hydroxylase, 11-beta-hydroxylase, 11-hydroxylase, 11beta hydroxylase, 11beta-hydroxylase, ALDOS, Aldosterone synthase, Aldosterone-synthesizing enzyme, C450XIB2, CYP11B1, CYP11B2, cyp11beta, CYPXIB, CYPXIB1, CYPXIB2, CYPXIB3, cytochrome 11beta-hydroxylase, cytochrome P-45011-beta, cytochrome P450 11B1, cytochrome P450 11B2, cytochrome P450 11beta-hydroxylase, cytochrome P45011beta, cytochrome P45011beta-hydroxylase, EC 1.14.1.6, EC 1.99.1.7, P-450(11 beta,aldo), P-450Aldo, P-450c11, P-450C18, P-450XIB1, P450 11beta-hydroxylase, P450(11 beta)-DS, P45011beta, P450C11, Steroid 11-beta-hydroxylase, steroid 11-hydroxylase, steroid 11beta-hydroxylase, steroid 11beta-monooxygenase, steroid 11beta/18-hydroxylase, Steroid 18-hydroxylase, steroid-11beta-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.15.4 steroid 11beta-monooxygenase

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Results	in table
14	Activating Compound
138	AA Sequence
9	Application
1	CAS Registry Number
36	Cloned(Commentary)
53	Cofactor
1	Crystallization (Commentary)
4812	Disease/ Diagnostics
2	Expression
16	General Information
15	General Stability
213	IC50 Value
224	Inhibitors
4	Ki Value [mM]
27	KM Value [mM]
39	Localization
3	Metals/Ions
22	Molecular Weight [Da]
62	Natural Substrates/ Products (Substrates)
83	Organism
7	Pathway
60	PDB ID
26	pH Optimum
1	pH Range
35	Protein Variants
21	Purification (Commentary)
15	Reaction
4	Reaction Type
80	Reference
104	Source Tissue
31	Specific Activity [micromol/min/mg]
20	Storage Stability
138	Substrates and Products (Substrate)
20	Subunits
139	Synonyms
1	Systematic Name
26	Temperature Optimum [°C]
2	Temperature Range [°C]
7	Temperature Stability [°C]
11	Turnover Number [1/s]

Sequence

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Sequence on EC 1.14.15.4 - steroid 11beta-monooxygenase

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P30099 pBLAST

C11B2_RAT

Rattus norvegicus

510

58241

Swiss-Prot