1.14.15.8: steroid 15beta-monooxygenase

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For detailed information about steroid 15beta-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.8

1.14.15.8

megaterium

p-450-dependent

ferredoxins

synthesis

adrenodoxin

autologous

triterpene

11-oxidase

testosterone

flavodoxin

flavoprotein

hydroxylases

aniline

11-deoxycortisol

nadph-dependent

fmn-containing

paramagnetic

iron-sulfur

biocatalyst

11-keto

11-deoxycorticosterone

Reaction

Synonyms

15beta-hydroxylase, 15beta-hydroxylase CYP106A2, BmCYP106A2, Cyp106A1, CYP106A2, cytochrome P-450meg, cytochrome P450meg, steroid-15-beta-monooxygenase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.15.8 steroid 15beta-monooxygenase

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Results	in table
3	Activating Compound
1	AA Sequence
3	Application
13	Cloned(Commentary)
14	Cofactor
2	Crystallization (Commentary)
1	General Stability
8	Inhibitors
8	Ki Value [mM]
32	KM Value [mM]
3	Metals/Ions
3	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
22	Organism
4	PDB ID
7	pH Optimum
1	pI Value
23	Protein Variants
6	Purification (Commentary)
1	Reaction
22	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
64	Substrates and Products (Substrate)
3	Subunits
22	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
3	Turnover Number [1/s]

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Cofactor on EC 1.14.15.8 - steroid 15beta-monooxygenase

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adrenodoxin

cytochrome P450

cytochrome P450meg

it is possible to resolve the hydroxylase system into three proteins: a strictly NADPH-dependent FMN-containing flavoprotein (megaredoxin reductase), an iron-sulfur protein (megaredoxin), and cytochrome P-450 (P-450meg). The activity of the 15beta-hydroxylase system is fully reconstituted upon combination of these three proteins and addition of NADPH. Megaredoxin has an apparent sulfur to iron ratio of 0.98 and shows g-signals at 1.90, 1.93, and 2.06 when analyzed by electron paramagnetic resonance spectroscopy

Ferredoxin

heme

NADPH