1.14.16.4: tryptophan 5-monooxygenase
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For detailed information about tryptophan 5-monooxygenase, go to the full flat file.
Word Map on EC 1.14.16.4
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1.14.16.4
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serotonin
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serotonergic
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raphe
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5-hydroxytryptamine
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monoamine
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dorsal
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dopamine
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neurotransmitter
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hippocampus
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antidepressant
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reuptake
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5-hydroxytryptophan
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anxiety
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psychiatric
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midbrain
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striatum
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hypothalamus
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neurochemical
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5-hydroxyindoleacetic
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mood
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enterochromaffin
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neurotransmission
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5-hiaa
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p-chlorophenylalanine
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fluoxetine
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pineal
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brainstem
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alpha-methyl-p-tyrosine
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monoaminergic
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5,7-dihydroxytryptamine
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analysis
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methamphetamine
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autoreceptors
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slc6a4
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immobility
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pargyline
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n-acetylserotonin
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neostriatal
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5-httlpr
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medicine
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citalopram
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antidepressant-like
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carcinoid
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biopterins
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impulsivity
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oxidase-a
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tetrahydropterins
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fenfluramine
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impulsive
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8-oh-dpat
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5-hydroxyindole
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drug development
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3,4-methylenedioxymethamphetamine
- 1.14.16.4
- serotonin
-
serotonergic
-
raphe
- 5-hydroxytryptamine
-
monoamine
-
dorsal
- dopamine
-
neurotransmitter
- hippocampus
-
antidepressant
-
reuptake
- 5-hydroxytryptophan
-
anxiety
-
psychiatric
- midbrain
- striatum
- hypothalamus
-
neurochemical
-
5-hydroxyindoleacetic
-
mood
-
enterochromaffin
-
neurotransmission
-
5-hiaa
- p-chlorophenylalanine
- fluoxetine
-
pineal
- brainstem
- alpha-methyl-p-tyrosine
-
monoaminergic
-
5,7-dihydroxytryptamine
- analysis
- methamphetamine
-
autoreceptors
-
slc6a4
-
immobility
- pargyline
- n-acetylserotonin
- neostriatal
-
5-httlpr
- medicine
- citalopram
-
antidepressant-like
- carcinoid
- biopterins
-
impulsivity
-
oxidase-a
- tetrahydropterins
- fenfluramine
-
impulsive
-
8-oh-dpat
- 5-hydroxyindole
- drug development
- 3,4-methylenedioxymethamphetamine
Reaction
Synonyms
hTPH2, indoleacetic acid-5-hydroxylase, L-tryptophan 5-hydroxylase, L-tryptophan hydroxylase, oxygenase, tryptophan 5-mono-, peripheral tryptophan hydroxylase, PTMO, putative tryptophan monooxygenase, TH2, TPH, TPH-1, TPH-2, TPH1, TPH2, TRpOH, tryptophan 5-hydroxylase, tryptophan 5-monooxygenase, tryptophan hydroxylase, tryptophan hydroxylase 1, tryptophan hydroxylase 2, tryptophan hydroxylase I, tryptophan hydroxylase isoform 1, tryptophan hydroxylase isoform 2, tryptophan hydroxylase isoform2, tryptophan hydroxylase type I, tryptophan hydroxylase-1, tryptophan hydroxylase-2, tryptophan-5-hydroxylase
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analysis
a Dugesia japonica TPH antibody is a useful marker for serotonergic neurons in planarians
drug development
medicine
additional information
enhancement of L-tryptophan hydroxylation activity of L-phenylalanine 4-hydroxylase from Chromobacterium violaceum using information on the crystal structures of aromatic amino acid hydroxylases including TPH
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substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel TPH1 inhibitors may provide novel treatments for gastrointestinal disorders associated with dysregulation of the serotonergic system, such as chemotherapy-induced emesis and irritable bowel syndrome
drug development
substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel TPH1 inhibitors may provide novel treatments for gastrointestinal disorders associated with dysregulation of the serotonergic system, such as chemotherapy-induced emesis and irritable bowel syndrome
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the two distinct serotonin systems in the brain (TPH2) and in the periphery (TPH1) can be targeted independently by pharmacological agents and new therapeutical options are available for psychiatric diseases on one side and disorders of haemostasis and the immune system on the other side
medicine
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TPH2 is a good candidate gene for 5-hydroxytryptophan related psychiatric diseases such as bipolar affective disorders. The two distinnct serotonin systems in the brain (TPH2) and in the periphery (TPH1) can be targeted independently by pharmacological agents and new therapeutical options are available for psychiatric diseases on one side and disorders of haemostasis and the immune system on the other side
medicine
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the serotonin transporter gene-linked promoter region 5-HTTLPR and tryptophan hydroxylase-2 genes act in concert to modulate the clinical response to citalopram among children and adolescents with depression and/or anxiety disorders