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1.14.16.4: tryptophan 5-monooxygenase

This is an abbreviated version!
For detailed information about tryptophan 5-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.4

Reaction

L-tryptophan
+
a 5,6,7,8-tetrahydropteridine
+
O2
=
5-hydroxy-L-tryptophan
+
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

hTPH2, indoleacetic acid-5-hydroxylase, L-tryptophan 5-hydroxylase, L-tryptophan hydroxylase, oxygenase, tryptophan 5-mono-, peripheral tryptophan hydroxylase, PTMO, putative tryptophan monooxygenase, TH2, TPH, TPH-1, TPH-2, TPH1, TPH2, TRpOH, tryptophan 5-hydroxylase, tryptophan 5-monooxygenase, tryptophan hydroxylase, tryptophan hydroxylase 1, tryptophan hydroxylase 2, tryptophan hydroxylase I, tryptophan hydroxylase isoform 1, tryptophan hydroxylase isoform 2, tryptophan hydroxylase isoform2, tryptophan hydroxylase type I, tryptophan hydroxylase-1, tryptophan hydroxylase-2, tryptophan-5-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.4 tryptophan 5-monooxygenase

Expression

Expression on EC 1.14.16.4 - tryptophan 5-monooxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme expression is induced by prolactin
-
enzyme expression is inhibited by a Jak2 inhibitor and partially inhibited by MEK1/2 inhibitor U0126 or PI3K inhibitor LY-294002
-
enzyme expression is reduced in ganglionic bowel in those affected by pre-operative Hirschsprung's-associated enterocolitis compared to those without Hirschsprung's-associated enterocolitis and healthy controls
-
imipramine increases dorsal raphe TPH2 gene expression in a glucocorticoid-dependent manner, increases are due to relief of inhibitory glucocorticoid signaling
-
TPH-1 mRNA is highly expressed in the total RNA extracted from the preoptic anterior hypothalamus and midbrain tegmentum compared with other brain areas
TPH-1 mRNA levels are significantly decreased in the hypothalami of croaker exposed for 2 weeks to hypoxic conditions compared with those in fish exposed to normoxic conditions. Hypoxia causes a marked decline in hypothalamic TPH protein levels, which is associated with a 65% decrease in hypothalamic TPH enzyme activity and a 60% decrease in 5-hydroxytryptophan levels
TPH-2 mRNA levels are significantly decreased in the hypothalami of croaker exposed for 2 weeks to hypoxic conditions compared with those in fish exposed to normoxic conditions. Hypoxia causes a marked decline in hypothalamic TPH protein levels, which is associated with a 65% decrease in hypothalamic TPH enzyme activity and a 60% decrease in 5-hydroxytryptophan levels
TPH-2 mRNA shows high expression in the preoptic anterior hypothalamus, midbrain tegmentum and cerebellum with optic tectum, compared with other brain areas