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1.14.16.4: tryptophan 5-monooxygenase

This is an abbreviated version!
For detailed information about tryptophan 5-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.4

Reaction

L-tryptophan
+
a 5,6,7,8-tetrahydropteridine
+
O2
=
5-hydroxy-L-tryptophan
+
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

hTPH2, indoleacetic acid-5-hydroxylase, L-tryptophan 5-hydroxylase, L-tryptophan hydroxylase, oxygenase, tryptophan 5-mono-, peripheral tryptophan hydroxylase, PTMO, putative tryptophan monooxygenase, TH2, TPH, TPH-1, TPH-2, TPH1, TPH2, TRpOH, tryptophan 5-hydroxylase, tryptophan 5-monooxygenase, tryptophan hydroxylase, tryptophan hydroxylase 1, tryptophan hydroxylase 2, tryptophan hydroxylase I, tryptophan hydroxylase isoform 1, tryptophan hydroxylase isoform 2, tryptophan hydroxylase isoform2, tryptophan hydroxylase type I, tryptophan hydroxylase-1, tryptophan hydroxylase-2, tryptophan-5-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.4 tryptophan 5-monooxygenase

Inhibitors

Inhibitors on EC 1.14.16.4 - tryptophan 5-monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S)-2-amino-5-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)pent-4-ynoic acid
-
-
(3R)-8-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
(3S)-8-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
(3S)-8-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-2-methyl-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
(6R)-5,6,7,8-tetrahydrobiopterin
-
-
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin
-
TPH2, substrate inhibition
(7R)-5,6,7,8-tetrahydrobiopterin
-
recombinant pinal enzyme, 2.1 mM, 50% inhibition
1,10-phenanthroline
2,2'-dipyridyl
-
-
2-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-2,6-diazaspiro[3.4]octane-7-carboxylic acid
-
-
3,4-dihydroxyphenylalanine
-
-
3,4-Dihydroxyphenylethylamine
-
-
3,4-Dihydroxystyrene
-
-
3,4-methylenedioxymethamphetamine
-
inactivation of the enzyme
3-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-N-(2-methylprop-2-en-1-yl)-3-azabicyclo[3.2.1]octan-8-amine
-
-
3-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)phenylalanine
-
-
3-amino-3-[1-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)piperidin-4-yl]propanoic acid
-
-
3-amino-3-[4-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)phenyl]propanoic acid
-
-
3-[(3R)-3-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)pyrrolidin-1-yl]-L-alanine
-
-
3-[1-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)piperidin-4-yl]propanoic acid
-
-
3-[1-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)piperidin-4-yl]alanine
-
-
3-[3-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-3,6-diazabicyclo[3.1.1]heptan-6-yl]-L-alanine
-
-
3-[3-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl]-L-alanine
-
-
3-[3-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-1H-pyrazol-1-yl]alanine
-
-
3-[4-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-1,4-diazepan-1-yl]-L-alanine
-
-
3-[4-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)piperazin-1-yl]-L-alanine
-
-
3-[5-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl]-L-alanine
-
-
3-[5-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)pyridin-2-yl]alanine
-
-
3-[6-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-3,6-diazabicyclo[3.1.1]heptan-3-yl]-L-alanine
-
-
3-[8-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl]-L-alanine
-
-
4-(4-amino-6-[methyl[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-L-phenylalanine
-
4-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-2-fluorophenylalanine
-
-
4-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-a-methylphenylalanine
-
-
4-(4-amino-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-L-phenylalanine
4-(4-amino-6-[[(1S)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl)-L-phenylalanine
-
4-(4-amino-6-[[(4'-methylbiphenyl-4-yl)methyl]amino]-1,3,5-triazin-2-yl)-L-phenylalanine
-
4-(4-amino-6-[[4-(trifluoromethyl)benzyl]amino]-1,3,5-triazin-2-yl)-L-phenylalanine
-
4-(5-[[(1-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)methyl]amino]pyrazin-2-yl)-L-phenylalanine
-
-
4-(5-[[(1-hydroxynaphthalen-2-yl)methyl]amino]pyrazin-2-yl)-L-phenylalanine
-
-
4-(5-[[(2'-methylbiphenyl-2-yl)methyl]amino]pyrazin-2-yl)-L-phenylalanine
-
-
4-(5-[[(9-ethyl-9H-carbazol-3-yl)methyl]amino]pyrazin-2-yl)-L-phenylalanine
-
-
4-(5-[[3-(cyclopentyloxy)-4-methoxybenzyl]amino]pyrazin-2-yl)-L-phenylalanine
-
-
4-([(E)-amino[([1,1'-biphenyl]-2-yl)amino]methylidene]carbamoyl)-L-phenylalanine
-
-
4-([(E)-amino[([2-(piperidin-1-yl)-6-[(propan-2-yl)oxy]phenyl]methyl)amino]methylidene]carbamoyl)-L-phenylalanine
-
-
4-([(E)-amino[([2-(piperidin-1-yl)-6-[2-(trifluoromethyl)phenoxy]phenyl]methyl)amino]methylidene]carbamoyl)-L-phenylalanine
-
-
4-([(E)-amino[([2-(piperidin-1-yl)-6-[3-(trifluoromethyl)phenoxy]phenyl]methyl)amino]methylidene]carbamoyl)-L-phenylalanine
-
-
4-([(E)-amino[([2-(piperidin-1-yl)-6-[4-(trifluoromethyl)phenoxy]phenyl]methyl)amino]methylidene]carbamoyl)-L-phenylalanine
-
-
4-chloro-L-phenylalanine
4-Chlorophenylalanine
4-ethynylphenylalanine
-
-
4-Fluorotryptophan
-
-
4-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-6-[4-[(2H-tetrazol-5-yl)amino]piperidin-1-yl]pyrimidin-2-amine
-
-
4-[(diaminomethylidene)carbamoyl]-L-phenylalanine
-
-
4-[4-(methylamino)-6-[[(1R)-1-naphthalen-2-ylethyl]amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-(1-naphthalen-2-ylethoxy)-1,3,5-triazin-2-yl]-L-phenylalanine
-
-
4-[4-amino-6-(2,2,2-trifluoro-1-naphthalen-2-ylethoxy)-1,3,5-triazin-2-yl]-L-phenylalanine
4-[4-amino-6-(2,2,2-trifluoro-1-[2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]ethoxy)-1,3,5-triazin-2-yl]-L-phenylalanine
-
-
4-[4-amino-6-(benzylamino)-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-([[4'-(trifluoromethyl)biphenyl-4-yl]methyl]amino)-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(1-biphenyl-4-ylethyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(1-methyl-1-naphthalen-2-ylethyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(1-naphthalen-2-ylpropyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(1-tricyclo[3.3.1.1(3,7)]dec-1-ylethyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(2,2,2-trifluoro-1-naphthalen-2-ylethyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(2-methyl-1-naphthalen-2-ylpropyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(3,4-dimethylbenzyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(3-methyl-1-naphthalen-2-ylbutyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(4-phenoxybenzyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(biphenyl-2-ylmethyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(biphenyl-3-ylmethyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(biphenyl-4-ylmethyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(cyclohexylmethyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[(naphthalen-2-ylmethyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-amino-6-[2,2,2-trifluoro-1-(2-furan-2-ylphenyl)ethoxy]-1,3,5-triazin-2-yl]-L-phenylalanine
-
-
4-[4-amino-6-[2,2,2-trifluoro-1-(3'-methylbiphenyl-2-yl)ethoxy]-1,3,5-triazin-2-yl]-L-phenylalanine
-
-
4-[4-amino-6-[2,2,2-trifluoro-1-(5-furan-2-ylthiophen-2-yl)ethoxy]-1,3,5-triazin-2-yl]-L-phenylalanine
-
-
4-[4-morpholin-4-yl-6-[(naphthalen-2-ylmethyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[4-[(1-naphthalen-2-ylethyl)amino]-1,3,5-triazin-2-yl]-L-phenylalanine
-
4-[5-[(3,4-dimethoxybenzyl)amino]pyrazin-2-yl]-L-phenylalanine
-
-
4-[5-[(4-cyanobenzyl)amino]pyrazin-2-yl]-L-phenylalanine
-
-
4-[5-[(biphenyl-4-ylmethyl)amino]pyrazin-2-yl]-L-phenylalanine
-
-
4-[5-[(cyclohexylmethyl)amino]pyrazin-2-yl]-L-phenylalanine
-
-
4-[5-[(furan-3-ylmethyl)amino]pyrazin-2-yl]-L-phenylalanine
-
-
4-[5-[(pyridin-3-ylmethyl)amino]pyrazin-2-yl]-L-phenylalanine
-
-
4-[5-[(quinolin-3-ylmethyl)amino]pyrazin-2-yl]-L-phenylalanine
-
-
4-[[(E)-amino(benzylamino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(1H-1,2,4-triazol-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(1H-pyrazol-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(2-azabicyclo[2.2.1]heptan-2-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(2-chlorophenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(2-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(2-methylphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(2-methylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(2H-1,2,3-triazol-2-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(3,5-dimethylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(3-chlorophenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(3-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(3-methyl-1H-pyrazol-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(3-methylphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(3-methylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(4-benzylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(4-chlorophenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(4-hydroxypiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(4-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(4-methoxypiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(4-methyl-1H-imidazol-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(4-methylphenoxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(4-phenylpiperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(azepan-1-yl)-6-methoxyphenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(azepan-1-yl)-6-phenoxyphenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(azepan-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(azetidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(cyclobutyloxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(cyclohexyloxy)-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(diethylamino)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(morpholin-4-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(piperidin-1-yl)-5-(1,3-thiazol-2-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(piperidin-1-yl)-6-(trifluoromethyl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(pyrrolidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-(thiomorpholin-4-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-chloro-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-ethoxy-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-methoxy-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-methyl-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[2-phenoxy-6-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[3-(piperidin-1-yl)[1,1'-biphenyl]-2-yl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[3-chloro-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[3-methoxy-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[3-methyl-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[4-(piperidin-1-yl)[1,1'-biphenyl]-3-yl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[4-chloro-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[4-methoxy-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[4-methyl-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[5-chloro-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[5-methoxy-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino([[5-methyl-2-(piperidin-1-yl)phenyl]methyl]amino)methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino[[([1,1'-biphenyl]-2-yl)methyl](methyl)amino]methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino[[([1,1'-biphenyl]-2-yl)methyl]amino]methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino[[([1,1'-biphenyl]-3-yl)methyl]amino]methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino[[([1,1'-biphenyl]-4-yl)methyl]amino]methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino[[2-([1,1'-biphenyl]-2-yl)ethyl]amino]methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-amino[[3-([1,1'-biphenyl]-2-yl)propyl]amino]methylidene]carbamoyl]-L-phenylalanine
-
-
4-[[(E)-[[([1,1'-biphenyl]-2-yl)methyl]amino](methylamino)methylidene]carbamoyl]-L-phenylalanine
-
-
5-Fluorotryptophan
-
-
5-hydroxytryptophan
6-Fluorotryptophan
7-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-2,7-diazaspiro[4.4]nonane-3-carboxylic acid
-
-
8-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-1,8-diazaspiro[4.5]decane-2-carboxylic acid
-
-
8-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
8-(4-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
8-(4-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-2-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
8-(5-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyridazin-3-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
8-(5-[(1S)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrazin-2-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
8-(6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-2-hydroxypyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
8-(6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-2-methylpyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
8-(6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-2-phenoxypyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
8-(6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrazin-2-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
8-(6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
8-hydroxyquinoline
-
-
8-[6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-2-(cyclohexylamino)pyrimidin-4-yl]-2,8-diazaspiro[4.5]decane-3-carboxylic acid
-
-
9-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-3,9-diazaspiro[5.5]undecane-2-carboxylic acid
-
-
Aroclor 1254
-
-
citalopram
selective serotonin reuptake inhibitors, like citalopram, exert their activity enhancing the general serotonergic tone, citalopram is the most selective one with little or no affinity for a variety of receptor types, association between gene TPH1 A218C polymorphism and citalopram antidepressant response in a Korean population, overview
Co2+
80% inhibition at 0.1 mM
CoCl2
-
1 mM, complete inhibition
D,L-4-chlorophenylalanine
D-Dopa
-
noncompetitive vs. L-tryptophan and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin
desferrioxamine
-
0.010 mM or higher, irreversible loss of activity
dithiothreitol
-
-
dopamine
ethyl (3S)-8-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate
-
-
Fe2+
-
-
H2O2
-
complete dependence on catalase in the absence of a mercaptan
iron chelators
-
L-4-chlorophenylalanine
-
-
L-5-hydroxytryptophan
-
-
L-Dopa
-
noncompetitive vs. L-tryptophan and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin
L-erythro-7,8-dihydrobiopterin
-
recombinant N-terminal truncated enzyme, competitive vs. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin
L-p-Chlorophenylalanine
-
-
L-phenylalanine
L-tryptophan
L-tyrosine
-
noncompetitive vs. L-tryptophan and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin
LP 533401
-
-
LP-533401
LP-615819
-
-
LP533401
-
-
LX-1033
-
-
Mn2+
50% inhibition at 0.01 mM
N-[1-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-3,5-dimethylpiperidin-4-yl]glycine
-
-
N-[1-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)-4-methylpiperidin-4-yl]glycine
-
-
N-[1-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)piperidin-4-yl]glycine
-
-
N-[4-(2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl)phenyl]methanesulfonamide
-
-
nifedipine
-
reduces the enzyme activity by blocking the Ca2+-influx accompanied with a reduction of 5-hydroxytryptophan, serotonin, N-acetylserotonin and melatonin intracellular content, as well as a reduction of serotonin and melatonin secretion
NVS-TPH120
-
-
-
NVS-TPH146
-
-
-
NVS-TPH176
-
-
-
NVS-TPH180
-
-
-
phenylalanine
-
-
serotonin
-
1 mM, 7.5% inhibition, 10 mM, 70% inhibition
tryptophan
substrate inhibition of the catalytic domain of TPH1
ZnSO4
-
1 mM, 80% inhibition
additional information
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