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1.14.16.4: tryptophan 5-monooxygenase

This is an abbreviated version!
For detailed information about tryptophan 5-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.4

Reaction

L-tryptophan
+
a 5,6,7,8-tetrahydropteridine
+
O2
=
5-hydroxy-L-tryptophan
+
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

hTPH2, indoleacetic acid-5-hydroxylase, L-tryptophan 5-hydroxylase, L-tryptophan hydroxylase, oxygenase, tryptophan 5-mono-, peripheral tryptophan hydroxylase, PTMO, putative tryptophan monooxygenase, TH2, TPH, TPH-1, TPH-2, TPH1, TPH2, TRpOH, tryptophan 5-hydroxylase, tryptophan 5-monooxygenase, tryptophan hydroxylase, tryptophan hydroxylase 1, tryptophan hydroxylase 2, tryptophan hydroxylase I, tryptophan hydroxylase isoform 1, tryptophan hydroxylase isoform 2, tryptophan hydroxylase isoform2, tryptophan hydroxylase type I, tryptophan hydroxylase-1, tryptophan hydroxylase-2, tryptophan-5-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.4 tryptophan 5-monooxygenase

Molecular Weight

Molecular Weight on EC 1.14.16.4 - tryptophan 5-monooxygenase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
162000
-
gel filtration
200000
-
recombinant pineal enzyme, gel filtration
220000 - 240000
-
enzyme from hindbrain
230000
-
gel filtration, PAGE, sucrose density gradient centrifugation
234000
-
TPH1, gel filtration
236000
-
gel filtration
240000
recombinant His-tagged enzyme, gel filtration
240300
gel-filtration
260000
-
enzyme from brain, gradient PAGE
270000
-
enzyme from mastocytoma cells, gel filtration
274000
-
TPH2, gel filtration
280000
288000
30000
-
enzyme from pineal gland, gel filtration, sucrose density gradient ultracentrifugation
300000
36100
catalytic domain of TPH1, gel filtration
36200
catalytic domain of TPH2, gel filtration
47000
-
x * 47000, recombinant enzyme, SDS-PAGE
50000
53000
-
4 * 53000, enzyme from mastocytoma cells, SDS-PAGE
55000
56000
57500
-
2 * 57500 + 2 * 60000, midbrain enzyme, SDS-PAGE
57700
-
2 * 57700 + 2 * 60900, hindbrain enzyme, SDS-PAGE
58500
-
4 * 58500, TPH1
59000
60000
60900
-
2 * 57700 + 2 * 60900, hindbrain enzyme, SDS-PAGE
68500
-
4 * 68500, TPH2
90000
-
x * 90000, SDS-PAGE
96000
-
4 * 96000, SDS-PAGE
97000
SDS-PAGE, maltose-binding protein fusion protein