1.14.16.4: tryptophan 5-monooxygenase

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For detailed information about tryptophan 5-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.4

1.14.16.4

serotonin

serotonergic

raphe

5-hydroxytryptamine

monoamine

dorsal

dopamine

neurotransmitter

hippocampus

antidepressant

reuptake

5-hydroxytryptophan

anxiety

psychiatric

midbrain

striatum

hypothalamus

neurochemical

5-hydroxyindoleacetic

mood

enterochromaffin

neurotransmission

5-hiaa

p-chlorophenylalanine

fluoxetine

pineal

brainstem

alpha-methyl-p-tyrosine

monoaminergic

5,7-dihydroxytryptamine

analysis

methamphetamine

autoreceptors

slc6a4

immobility

pargyline

n-acetylserotonin

neostriatal

5-httlpr

medicine

citalopram

antidepressant-like

carcinoid

biopterins

impulsivity

oxidase-a

tetrahydropterins

fenfluramine

impulsive

8-oh-dpat

5-hydroxyindole

drug development

3,4-methylenedioxymethamphetamine

Reaction

a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

hTPH2, indoleacetic acid-5-hydroxylase, L-tryptophan 5-hydroxylase, L-tryptophan hydroxylase, oxygenase, tryptophan 5-mono-, peripheral tryptophan hydroxylase, PTMO, putative tryptophan monooxygenase, TH2, TPH, TPH-1, TPH-2, TPH1, TPH2, TRpOH, tryptophan 5-hydroxylase, tryptophan 5-monooxygenase, tryptophan hydroxylase, tryptophan hydroxylase 1, tryptophan hydroxylase 2, tryptophan hydroxylase I, tryptophan hydroxylase isoform 1, tryptophan hydroxylase isoform 2, tryptophan hydroxylase isoform2, tryptophan hydroxylase type I, tryptophan hydroxylase-1, tryptophan hydroxylase-2, tryptophan-5-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor

1.14.16.4 tryptophan 5-monooxygenase

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Results	in table
34	Activating Compound
1884	AA Sequence
7	Application
1	CAS Registry Number
66	Cloned(Commentary)
9	Cofactor
7	Crystallization (Commentary)
662	Disease/ Diagnostics
8	Expression
8	General Information
23	General Stability
173	IC50 Value
243	Inhibitors
23	Ki Value [mM]
127	KM Value [mM]
13	Localization
25	Metals/Ions
46	Molecular Weight [Da]
110	Natural Substrates/ Products (Substrates)
298	Organism
6	Pathway
28	PDB ID
17	pH Optimum
3	pH Range
1	pH Stability
6	Posttranslational Modification
80	Protein Variants
45	Purification (Commentary)
3	Reaction
3	Reaction Type
154	Reference
230	Source Tissue
34	Specific Activity [micromol/min/mg]
15	Storage Stability
242	Substrates and Products (Substrate)
25	Subunits
259	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
7	Temperature Stability [°C]
17	Turnover Number [1/s]

Sequence

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Sequence on EC 1.14.16.4 - tryptophan 5-monooxygenase

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P70080 pBLAST

TPH1_CHICK

Gallus gallus

445

51139

Swiss-Prot