1.14.17.3: peptidylglycine monooxygenase

This is an abbreviated version!
For detailed information about peptidylglycine monooxygenase, go to the full flat file.

Reaction

Synonyms

alpha-AE, bifunctional PAM, bifunctional peptidylglycine alpha-amidating monooxygenase, CG3832, hPHMcc, More, PAM, PAM-1, PAM-2, PAM-A, PAM-B, PAM/PHM, peptide alpha-amidating enzyme, peptide alpha-amide synthase, peptide-alpha-amide synthetase, peptidyl alpha-amidating enzyme, peptidyl alpha-hydroxylating monooxygenase, peptidyl-glycine alpha-amidating monooxygenase, peptidylglycine 2-hydroxylase, peptidylglycine alpha-amidating mono-oxygenase, peptidylglycine alpha-amidating monooxygenase, peptidylglycine alpha-hydroxylase, peptidylglycine alpha-hydroxylating monooxygenase, peptidylglycine alpha-hydroxylating-monooxygenase, peptidylglycine alpha-monooxygenase, peptidylglycine monooxygenase, peptidylglycine-alpha-amidating monooxygenase, PHM, PHMcc, synthase, peptide alpha-amide, type A PAM

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.17.3 peptidylglycine monooxygenase

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Results	in table
6	Activating Compound
644	AA Sequence
9	Application
1	CAS Registry Number
43	Cloned(Commentary)
70	Cofactor
2	Crystallization (Commentary)
24	Disease/ Diagnostics
1	Expression
24	General Information
4	General Stability
24	IC50 Value
162	Inhibitors
1	kcat/KM [mM/s]
79	Ki Value [mM]
168	KM Value [mM]
43	Localization
81	Metals/Ions
37	Molecular Weight [Da]
83	Natural Substrates/ Products (Substrates)
101	Organism
3	Oxidation Stability
31	PDB ID
48	pH Optimum
5	pH Range
1	pH Stability
2	Posttranslational Modification
47	Protein Variants
44	Purification (Commentary)
30	Reaction
29	Reaction Type
99	Reference
116	Source Tissue
52	Specific Activity [micromol/min/mg]
372	Substrates and Products (Substrate)
19	Subunits
193	Synonyms
1	Systematic Name
31	Temperature Optimum [°C]
1	Temperature Stability [°C]
30	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 1.14.17.3 - peptidylglycine monooxygenase

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MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

100000

Homo sapiens

-

PAM, determined by SDS-PAGE and Western blot analysis

699036

110000

Rattus norvegicus

-

x * 125000, PAM-1, SDS-PAGE, x * 110000, PAM-2, SDS-PAGE, x * 90000, PAM-3, SDS-PAGE

658458

125000

Rattus norvegicus

-

x * 125000, PAM-1, SDS-PAGE, x * 110000, PAM-2, SDS-PAGE, x * 90000, PAM-3, SDS-PAGE

658458

35000

Rattus norvegicus

-

PHM, proteolytic processed, determined by SDS-PAGE and Western blot analysis

698532

35040

Rattus norvegicus

-

MALDI-MS, recombinant enzyme

676976

38000

Bos taurus

-

PAM-B, heterogeneous in size, gel filtration

438570

39000

2 entries

40000

2 entries

42000

Rattus norvegicus

-

PHM, determined by SDS-PAGE and Western blot analysis

698532

43000

2 entries

48000

Bos taurus

-

1 * 48000, PAM-A, heterogeneous in size, SDS-PAGE

438570

49000

Bos taurus

-

form 1, gel filtration

438582

50000

2 entries

54000

Bos taurus

-

PAM-A, heterogeneous in size, gel filtration

438570

60000

3 entries

69000

Bos taurus

-

form 2, gel filtration

438582

74000

Xenopus laevis

-

1 * 74000, recombinant mutant AE-II, form 2, SDS-PAGE

438584

75000

3 entries

78000

Xenopus laevis

-

recombinant mutant AE-II, form 2, gel filtration

438584

87000

Mus musculus

-

determined by SDS-PAGE and Western Blot analysis

697630

90000

Rattus norvegicus

-

x * 125000, PAM-1, SDS-PAGE, x * 110000, PAM-2, SDS-PAGE, x * 90000, PAM-3, SDS-PAGE

658458

91000

Homo sapiens

P19021

x * 91000, recombinant soluble enzyme, SDS-PAGE

648703

92000

Sus scrofa

-

gel filtration

438579

95000

Rattus norvegicus

-

gel filtration

673155

additional information

3 entries

39000

Xenopus laevis

-

SDS-PAGE, gel filtration

438569, 438573

39000

Xenopus laevis

-

native wild-type enzyme

438569

40000

Sus scrofa

-

gel fltration, SDS-PAGE

438563

40000

Xenopus laevis

-

x * 40000, recombinant enzyme, SDS-PAGE

660417

43000

Xenopus laevis

-

recombinant wild-type enzyme, SDS-PAGE, gel filtration

438569

43000

Rattus norvegicus

-

recombinant form B, gel filtration and SDS-PAGE

438571

50000

Rattus norvegicus

-

gel filtration

438562

50000

Aplysia californica

-

1 * 50000, membrane-bound form, SDS-PAGE

438586

60000

Sus scrofa

-

gel filtration

438564

60000

Aplysia californica

-

gel filtration

438586

60000

Sus scrofa

-

shows reversible aggregation with MW of 100000

438564

75000

Rattus norvegicus

-

gel filtration and native PAGE

438574

75000

Rattus norvegicus

-

recombinant from mouse cells, gel filtration

438566

75000

Rattus norvegicus

-

recombinant form A, gel filtration and SDS-PAGE

438571, 438589

additional information

Rattus norvegicus

-

-

438587

additional information

Bos taurus

-

-

438567

additional information

Rattus norvegicus

-

PAM in particulate fraction of H9c2 cells contains 86, 76, and 46 kDa proteins, soluble PAM fraction contains 110, 86, and 46 kDa proteins

438588