1.14.17.3: peptidylglycine monooxygenase This is an abbreviated version! For detailed information about peptidylglycine monooxygenase, go to the full flat file .
Word Map on EC 1.14.17.3
Reaction
[peptide]-glycine +
2 ascorbate
+
O2 =
[peptide]-(2S)-2-hydroxyglycine +
2 monodehydroascorbate
+
H2O
Synonyms alpha-AE, bifunctional PAM, bifunctional peptidylglycine alpha-amidating monooxygenase, CG3832, hPHMcc, More, PAM, PAM-1, PAM-2, PAM-A, PAM-B, PAM/PHM, peptide alpha-amidating enzyme, peptide alpha-amide synthase, peptide-alpha-amide synthetase, peptidyl alpha-amidating enzyme, peptidyl alpha-hydroxylating monooxygenase, peptidyl-glycine alpha-amidating monooxygenase, peptidylglycine 2-hydroxylase, peptidylglycine alpha-amidating mono-oxygenase, peptidylglycine alpha-amidating monooxygenase, peptidylglycine alpha-hydroxylase, peptidylglycine alpha-hydroxylating monooxygenase, peptidylglycine alpha-hydroxylating-monooxygenase, peptidylglycine alpha-monooxygenase, peptidylglycine monooxygenase, peptidylglycine-alpha-amidating monooxygenase, PHM, PHMcc, synthase, peptide alpha-amide, type A PAM
ECTree
Source Tissue
Source Tissue on EC 1.14.17.3 - peptidylglycine monooxygenase
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from neonatal rats
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expression only in the photoreceptor cells adjacent to the eye cup
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abdominal and pleuropedal
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peptidylglycine monooxygenase from the HL-1 cell line shows a 5fold higher specific activity compared to the enzyme from rat atrium
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atrial myocyte
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neuronal cell bodies, axon bundles
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midbrain
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predominantly membrane-associated, bifunctional enzyme
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primary anterior pituitary cells
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myoblast, H9c2 cells
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atrium
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predominantly membrane-associated, bifunctional enzyme
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atrium
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ventricle
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PAM-1 and PAM-2
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2 forms, distinguishable by molecular weight
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PAM-1 and PAM-2
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transplantable
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neuroendocrine Tv cells of larval brains
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neurointermediate
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anterior
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anterior, intermediate and posterior
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primary anterior pituitary cells
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peptidylglycine alpha-amidating monooxygenase activity in copper-deficient lactating dams is reduced to 15% compared to controls. Pups fed by copper-deficient dams showed an earlier decrease of peptidylglycine alpha-amidating monooxygenase activity throughout lactation
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peptidylglycine alpha-amidating monooxygenase activity in copper-deficient lactating dams is reduced to 15% compared to controls. Pups fed by copper-deficient dams showed an earlier decrease of peptidylglycine alpha-amidating monooxygenase activity throughout lactation
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soluble enzyme with peptidylglycine alpha-hydroxylating activity, AE-I
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soluble enzyme with peptidylglycine alpha-hydroxylating activity or peptidylhydroxylglycine N-C lyase activity
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additional information
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tissue distribution, overview
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additional information
tissue expression pattern, the enzyme colocalizes with cytochrome b561 along the central nervous system
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enzyme expression level in different tissues in copper adequate and deficient status, overview
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additional information
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enzyme expression level in different tissues in copper adequate and deficient status, overview
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additional information
Atp7a, AP-1, and PAM co-localize in the Golgi region of primary pituitary cells
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additional information
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tissue distribution, overview
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