1.14.18.1: tyrosinase

This is an abbreviated version!
For detailed information about tyrosinase, go to the full flat file.

Word Map on EC 1.14.18.1

1.14.18.1

melanin

melanoma

melanocyte

melanogenesis

melanosomes

cosmetic

microphthalmia-associated

hyperpigmentation

melanogenic

catechols

polyphenols

kojic

copper

albinism

whitening

hair

keratinocytes

albino

flavonoid

biosensors

o-quinone

amperometric

phytochemical

pigmentary

vitiligo

tautomerase

laccase

abts

alpha-msh

melanization

depigmentation

hydroquinone

electrode

melanocortins

2,2-diphenyl-1-picrylhydrazyl

copper-binding

polyphenoloxidase

frap

biotechnology

agriculture

pharmacology

hla-a2

nutrition

1,1-diphenyl-2-picrylhydrazyl

food industry

hemocyanins

environmental protection

l-3,4-dihydroxyphenylalanine

crest-derived

drug development

microphthalmia

medicine

agaricus

butyrylcholinesterase

melanoma-associated

copper-containing

decolor

bisporus

Reaction

2 L-dopa +

= 2 dopaquinone + 2 H2O

Synonyms

AbPPO1, AbPPO4, AbTYR, aurone synthase, catalase-phenol oxidase, catechol oxidase, catecholase, CATPO, chlorogenic acid oxidase, chlorogenic oxidase, cresolase, cresolase/monophenolase, CsPPO, CZA14Tyr, deoxy-tyrosinase, dihydroxy-L-phenylalanine:oxygen oxidoreductase, Diphenol oxidase, diphenolase, dopa oxidase, EC 1.10.3.1, EC 1.14.17.2, Hc-derived phenoloxidase, Hc-phenoloxidase, HcPO, HdPO, hemocyanin-derived phenoloxidase, jrPPO1, jrTYR, L-DOPA monophenolase, L-DOPA oxidase, L-DOPA:oxygen oxidoreductase, L-tyrosine hydroxylase, MdPPO1, melC2, MelC2 tyrosinase, met-tyrosinase, monophenol dihydroxyphenylalanine:oxygen oxidoreductase, monophenol monooxidase, monophenol monooxygenase, monophenol monoxygenase, monophenol oxidase, monophenol oxygen oxidoreductase, monophenol, 3,4-dihydroxy L-phenylalanine (L-DOPA):oxygen oxidoreductase, monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase, monophenol, dihydroxy-L-phenylalanine:oxygen oxidoreductase, monophenol, dihydroxyphenylalanine:oxygen oxidoreductase, monophenol, L-Dopa: oxidoreductase, monophenol, L-DOPA: oxygen oxidoreductase, monophenol, o-diphenol: oxygen oxidoreductase, monophenol, o-diphenol:O2 oxidoreductase, monophenol, o-diphenol:oxygen oxido-reductase, monophenol, o-diphenol:oxygen oxidoreductase, monophenol, polyphenol oxidase, monophenol: dioxygen oxidoreductases, hydroxylating, monophenolase, monphenol mono-oxygenase, More, mTyr, murine tyrosinase, mushroom tyrosinase, mushroom tyrosine, N-acetyl-6-hydroxytryptophan oxidase, o-diphenol oxidase, o-diphenol oxidoreductase, o-diphenol oxygen oxidoreductase, o-diphenol: O2 oxidoreductase, o-diphenol: oxidoreductase, o-diphenol:O2 oxidoreductase, o-diphenol:oxygen oxidoreductase, o-diphenolase, OCA1, Orf13, oxygen oxidoreductase, phenol oxidase, phenol oxidases, phenolase, phenoloxidase, PO, polyaromatic oxidase, polyphenol oxidase, polyphenol oxidase 3, polyphenol oxidase 4, polyphenol oxidase B, polyphenolase, polyphenoloxidase, PotPPO, PPO, PPO 3, PPO B, PPO1, PPO2, PPO3, pro-PO III, prophenoloxidase III, pyrocatechol oxidase, SPRTyr, ST94, ST94t, tryosinase, tryrosinase, TY, tyr, TYR1, TYR2, tyrA, TyrBm, tyrosinase, tyrosinase 2, tyrosinase 4, tyrosinase diphenolase, tyrosine-dopa oxidase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor

1.14.18.1 tyrosinase

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Results	in table
132	Activating Compound
2612	AA Sequence
40	Application
1	CAS Registry Number
43	Cloned(Commentary)
10	Cofactor
12	Crystallization (Commentary)
8024	Disease/ Diagnostics
7	Expression
81	General Information
10	General Stability
803	IC50 Value
1765	Inhibitors
56	kcat/KM [mM/s]
274	Ki Value [mM]
587	KM Value [mM]
53	Localization
181	Metals/Ions
180	Molecular Weight [Da]
210	Natural Substrates/ Products (Substrates)
39	Organic Solvent Stability
469	Organism
10	Pathway
103	PDB ID
199	pH Optimum
65	pH Range
38	pH Stability
16	pI Value
30	Posttranslational Modification
61	Protein Variants
153	Purification (Commentary)
24	Reaction
3	Reaction Type
463	Reference
2	Renatured (Commentary)
328	Source Tissue
164	Specific Activity [micromol/min/mg]
35	Storage Stability
1490	Substrates and Products (Substrate)
128	Subunits
643	Synonyms
1	Systematic Name
127	Temperature Optimum [°C]
28	Temperature Range [°C]
94	Temperature Stability [°C]
220	Turnover Number [1/s]

Source Tissue

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Source Tissue on EC 1.14.18.1 - tyrosinase

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tissue with the major amount of phenol oxidase activity

mouse melanoma cell

B16F10 melanoma cell

in the carapace, in the caudal zone and in the cuticle of the abdomen, mainly where the cuticle segments are joined and where the cuticle is connected to the pleopods

675164

commercial preparation

of maize seeds

Emerita asiatica

Emerita asiatica

eye

tyrosinase 4

R cell of hepatopancreas.No difference in locatation in nonirradiated and irradiated tissues, 5 kGy by a Co-60 radiation source

ink

from the first abdominal segment, no difference in locatation in nonirradiated and irradiated tissues, 5 kGy by a Co-60 radiation source

human normal epidermis melanocytes

pharyngeal epithelium

culture

prepared from the TXM13 melanotic cells as well as from cells that had undergone gene transfection

687841

additional information

10 entries