1.14.18.4: phosphatidylcholine 12-monooxygenase

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For detailed information about phosphatidylcholine 12-monooxygenase, go to the full flat file.

Word Map on EC 1.14.18.4

1.14.18.4

triacylglycerols

ricinus

communis

bean

desaturase

purpurea

claviceps

phospholipase

fendleri

oilseed

linoleate

lesquerella

seed-specific

desaturation

lesquerolic

synthesis

petrochemical

18-carbon

condensing

Reaction

a 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine

+ 2 ferrocytochrome b5 +

+ 2 H+ =

a 1-acyl-2-[(12R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine

+ 2 ferricytochrome b5 +

Synonyms

castor DELTA12-hydroxylase, CFAH12, CFAH12 protein, CpFAH, CpFAH12, DELTA12 oleate hydroxylase, EC 1.14.13.26, FAH, FAH12, LFAH12, oleate 12-hydroxylase, oleate DELTA12-hydroxylase, oleate hydroxylase, oleoyl-12-hydroxylase, oxygenase, oleate DELTA12-mono, ricinoleic acid synthase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor

1.14.18.4 phosphatidylcholine 12-monooxygenase

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Results	in table
1	Activating Compound
4	AA Sequence
4	Application
1	CAS Registry Number
12	Cloned(Commentary)
4	Cofactor
2	General Information
2	Inhibitors
1	KM Value [mM]
5	Localization
1	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
17	Organism
2	Pathway
3	pH Optimum
5	Protein Variants
1	Reaction
3	Reaction Type
17	Reference
8	Source Tissue
24	Substrates and Products (Substrate)
3	Subunits
24	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.14.18.4 - phosphatidylcholine 12-monooxygenase

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1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,ferrocytochrome-b5:oxygen oxidoreductase (12-hydroxylating)

The enzyme, characterized from the plant Ricinus communis (castor bean), is involved in production of the 12-hydroxylated fatty acid ricinoleate. The enzyme, which shares sequence similarity with fatty-acyl desaturases, requires a cytochrome b5 as the electron donor.