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1.14.18.6: 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

This is an abbreviated version!
For detailed information about 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase, go to the full flat file.

Word Map on EC 1.14.18.6

Reaction

a phytoceramide
+ 2 ferrocytochrome b5 +
O2
 + 2 H+ =
a (2'R)-2'-hydroxyphytoceramide
 + 2 ferricytochrome b5 +
H2O

Synonyms

FA2H, AtFAH1, FA2H, FAH1, fatty acid 2-hydroxylase, fatty acid 2-hydroxylase 1, fatty acid alpha-hydroxylase, SCS7, Scs7p, scScs7p, sphingolipid alpha-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.6 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

Engineering

Engineering on EC 1.14.18.6 - 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D323A
site-directed mutagenesis, the mutation results in partial loss of syringomycin E sensitivity
H173A
site-directed mutagenesis, the mutation results in partial loss of syringomycin E sensitivity
H244A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H249A
site-directed mutagenesis, the mutation results in partial loss of syringomycin E sensitivity
H264A
site-directed mutagenesis, the mutation results in unaltered syringomycin E sensitivity compared to the wild-type
H268A
site-directed mutagenesis, the mutation results in partial loss of syringomycin E sensitivity
H271A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H272A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H326A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H330A
site-directed mutagenesis, the mutation results in complete loss of syringomycin E sensitivity
H331A
site-directed mutagenesis, the mutation results in unaltered syringomycin E sensitivity compared to the wild-type
H345A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H348A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
H349A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
Y319A
site-directed mutagenesis, the mutation results in unaltered syringomycin E sensitivity compared to the wild-type
Y322A
site-directed mutagenesis, the mutation results in major loss of syringomycin E sensitivity
additional information