1.14.18.6: 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

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For detailed information about 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase, go to the full flat file.

Reaction

Synonyms

FA2H, AtFAH1, FA2H, FAH1, fatty acid 2-hydroxylase, fatty acid 2-hydroxylase 1, fatty acid alpha-hydroxylase, SCS7, Scs7p, scScs7p, sphingolipid alpha-hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.18.6 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

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Results	in table
1	Activating Compound
3	AA Sequence
2	Application
5	Cloned(Commentary)
6	Cofactor
2	Crystallization (Commentary)
210	Disease/ Diagnostics
5	Expression
16	General Information
6	Localization
2	Metals/Ions
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
19	Organism
2	Pathway
18	Protein Variants
2	Purification (Commentary)
1	Reaction
19	Reference
14	Source Tissue
9	Substrates and Products (Substrate)
2	Subunits
24	Synonyms
1	Systematic Name

Expression

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Expression on EC 1.14.18.6 - 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

DELTA9-tetrahydrocannabinol together with induced levels of peroxisome proliferator-activated receptor alpha significantly stimulate the expression of fatty acid 2 hydroxylase

Homo sapiens

-

743867

differentiation-dependent up-regulation of ceramide synthesis and fatty acid elongation is accompanied by up-regulation of FA2H

Homo sapiens

Q7L5A8

734156

fatty acid 2-hydroxylase (FA2H) is upregulated in vitro by nimodipine, a component of myelin synthesis. Nimodipine but not nifedipine increases FA2H protein levels and also significantly increases mRNA levels of FA2H in both undifferentiated and differentiated Neuro2a cells. Osmotic (NaCl) stress increases FA2H mRNA expression, synergistically with nifedipine-induced stress, overview

Mus musculus

Q5MPP0

745119

nimodipine promotes expression of fatty acid 2-hydroxylase in a surgical stress model based on Neuro2a cells

Mus musculus

-

742708

treatment of D6P2T Schwannoma cells with dibutyryl-cAMP induces exit from the cell cycle with concomitant upregulation of FA2H

Rattus norvegicus

-

734432