1.14.19.1: stearoyl-CoA 9-desaturase
This is an abbreviated version!
For detailed information about stearoyl-CoA 9-desaturase, go to the full flat file.
Word Map on EC 1.14.19.1
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1.14.19.1
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sickle
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cardiac
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children
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ventricular
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pain
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hemoglobin
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arrhythmia
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vaso-occlusive
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transfusion
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anemia
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infarct
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cardiomyopathy
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episode
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cardiovascular
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coronary
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myocardial
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artery
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stratification
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polyunsaturated
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ejection
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hydroxyurea
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stroke
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monounsaturated
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crises
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chest
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defibrillator
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desaturation
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lipogenesis
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arrhythmogenic
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tachycardia
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hemoglobinopathy
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all-cause
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cardioverter
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pufas
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cardioverter-defibrillator
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desaturases
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electrocardiogram
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lipogenic
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transfused
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pharmacology
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thalassemia
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12-lead
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palmitoleic
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agriculture
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tachyarrhythmias
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caregiver
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out-of-hospital
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resynchronization
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medicine
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transcranial
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syncope
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drug development
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holter
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alloimmunization
- 1.14.19.1
-
sickle
- cardiac
- children
- ventricular
- pain
- hemoglobin
- arrhythmia
-
vaso-occlusive
-
transfusion
- anemia
- infarct
- cardiomyopathy
- episode
- cardiovascular
- coronary
- myocardial
- artery
-
stratification
-
polyunsaturated
-
ejection
- hydroxyurea
- stroke
-
monounsaturated
- crises
- chest
-
defibrillator
-
desaturation
-
lipogenesis
-
arrhythmogenic
- tachycardia
- hemoglobinopathy
-
all-cause
-
cardioverter
-
pufas
-
cardioverter-defibrillator
-
desaturases
-
electrocardiogram
-
lipogenic
-
transfused
- pharmacology
- thalassemia
-
12-lead
-
palmitoleic
- agriculture
- tachyarrhythmias
-
caregiver
-
out-of-hospital
-
resynchronization
- medicine
-
transcranial
- syncope
- drug development
-
holter
-
alloimmunization
Reaction
Synonyms
ACOD4, acyl coenzyme A desaturase, acyl-CoA desaturase, delta-9 desaturase, DELTA9 desaturase, DELTA9 fatty acid desaturase, DELTA9 terminal desaturase, DELTA9-acyl CoA desaturase, DELTA9-desaturase, DELTA9-fatty-acid desaturase, DELTA9D, DesA3, desaturase 9, Dpu-DELTA9-KPSE, EC 1.14.99.5, eicosatrienoyl-CoA desaturase, FAD9, fatty acid 9-desaturase, fatty acid DELTA9-desaturase, fatty acid desaturase, fatty acyl CoA DELTA9-desaturase, fatty acyl DELTA9-desaturase, fatty acyl-CoA desaturase, hSCD1, hSCD5, long-chain fatty acid DELTA9-desaturase, membrane-bound stearoyl-CoA DELTA9 desaturase, NPVE desaturase, palmitoyl CoA desaturase, palmitoyl-CoA desaturase, SCD, SCD-1, SCD-2, SCD-3, SCD-4, SCD1, SCD2, SCD3, SCD4, SCD5, stearoyl CoA desaturase, stearoyl coenzyme A desaturase, stearoyl coenzyme-A desaturase 1, stearoyl-ACP DELTA9 desaturase, stearoyl-CoA (DELTA8) desaturase, stearoyl-CoA desaturase, stearoyl-CoA desaturase 1, stearoyl-CoA desaturase 2, stearoyl-CoA desaturase enzyme-1, stearoyl-CoA desaturase-1, stearoyl-CoA desaturase-2, stearoyl-CoA desaturase-3, stearoyl-CoA desaturase-4, stearoyl-CoA desaturase-5, stearoyl-CoA desaturase1, stearoyl-CoA desaturase2, stearoyl-coenzyme A desaturase, stearoyl-coenzyme A desaturase-1, stearyl coenzyme A desaturase, stearyl-CoA desaturase, TkSCD-1, TkSCD-2
ECTree
1.14.19.1 stearoyl-CoA 9-desaturaseAdvanced search results
results (
results (Engineering
Engineering on EC 1.14.19.1 - stearoyl-CoA 9-desaturase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C222S
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with Myc epitope tagged to the C terminus, expressed in HeLa cells, actitivity comparable to that of the wild-type
C233S
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with Myc epitope tagged to the C terminus, expressed in HeLa cells, actitivity comparable to that of the wild-type
C322S
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with Myc epitope tagged to the C terminus, expressed in HeLa cells, actitivity comparable to that of the wild-type
C92S
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with Myc epitope tagged to the C terminus, expressed in HeLa cells, actitivity comparable to that of the wild-type
C92S/C97S/C222S/C322S
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with Myc epitope tagged to the C terminus, expressed in HeLa cells, actitivity 5fold increased compared with cells transfected with the empty vector, clear ER pattern
C97S
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with Myc epitope tagged to the C terminus, expressed in HeLa cells, actitivity comparable to that of the wild-type
I112A/E113L
site-directed mutagenesis, the mutation is able to convert isozyme SCD3 from exclusively a 16:0 desaturase into a predominantly 18:0 desaturase
V119A/D281Q/P282S E113L
site-directed mutagenesis, the mutation of the residues which are located away from the end of the substrate tunnel, causes no change in the reaction specificity of isozyme SCD3
additional information
additional information
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fusion protein of enzyme isoform ADS1 or ADS2 with plastid targeting sequence of palmitic acid DELTA7 desaturase targets enzymes to plastid and shifts regiospecificity of enzymes from DELTA9 desaturase to DELTA7 desaturase
additional information
near complete transfer of the in vitro expressed enzyme integral membrane protein into the liposomes, followed by single step purification via centrifugation in a density gradient yielded proteoliposomes with the desaturase in high purity as judged by capillary electrophoresis, overview
additional information
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near complete transfer of the in vitro expressed enzyme integral membrane protein into the liposomes, followed by single step purification via centrifugation in a density gradient yielded proteoliposomes with the desaturase in high purity as judged by capillary electrophoresis, overview
additional information
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activities of enzymes with HA epitope tagged to the N terminus and Myc epitope tagged to the C terminus expressed in HeLa cells are 23fold and 39fold higher than in cells transfected with an empty vector, acitivities of enzymes with HA epitope after amino acid 93 and 138 additionally Myc epitope tagged to the C terminus are 5.5fold and 5.9fold higher than in cells transfected with an empty vector, respectively
additional information
leptin-deficient obese ob/ob mice lacking SCD1 showed markedly reduced adiposity, despite higher food intake
additional information
leptin-deficient obese ob/ob mice lacking SCD1 showed markedly reduced adiposity, despite higher food intake
additional information
leptin-deficient obese ob/ob mice lacking SCD1 showed markedly reduced adiposity, despite higher food intake
additional information
leptin-deficient obese ob/ob mice lacking SCD1 showed markedly reduced adiposity, despite higher food intake
additional information
mice with targeted disruption in the SCD1 gene have increased energy expenditure, reduced body adiposity, increased insulin sensitivity and are resistant to diet-induced obesity
additional information
mice with targeted disruption in the SCD1 gene have increased energy expenditure, reduced body adiposity, increased insulin sensitivity and are resistant to diet-induced obesity
additional information
mice with targeted disruption in the SCD1 gene have increased energy expenditure, reduced body adiposity, increased insulin sensitivity and are resistant to diet-induced obesity
additional information
mice with targeted disruption in the SCD1 gene have increased energy expenditure, reduced body adiposity, increased insulin sensitivity and are resistant to diet-induced obesity
additional information
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Myc epitope at the C terminus and additional HA epitope at predicted loops, after amino acid 93, 138 or 241
additional information
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no activity when HA epitope is inserted after amino acid 241
additional information
SCD1 -/- mice have a decrease in cellular levels of malonyl-CoA in the liver
additional information
SCD1 -/- mice have a decrease in cellular levels of malonyl-CoA in the liver
additional information
SCD1 -/- mice have a decrease in cellular levels of malonyl-CoA in the liver
additional information
SCD1 -/- mice have a decrease in cellular levels of malonyl-CoA in the liver
additional information
SCD1 deficiency attenuates fasting-induced liver steatosis in peroxisome proliferator-activated receptor alpha-deficient mice
additional information
SCD1 deficiency attenuates fasting-induced liver steatosis in peroxisome proliferator-activated receptor alpha-deficient mice
additional information
SCD1 deficiency attenuates fasting-induced liver steatosis in peroxisome proliferator-activated receptor alpha-deficient mice
additional information
SCD1 deficiency attenuates fasting-induced liver steatosis in peroxisome proliferator-activated receptor alpha-deficient mice
additional information
SCD1 deficiency corrects the hypometabolic phenotype and hepatic steatosis of ob/ob mice
additional information
SCD1 deficiency corrects the hypometabolic phenotype and hepatic steatosis of ob/ob mice
additional information
SCD1 deficiency corrects the hypometabolic phenotype and hepatic steatosis of ob/ob mice
additional information
SCD1 deficiency corrects the hypometabolic phenotype and hepatic steatosis of ob/ob mice
additional information
SCD1 deficiency increases the rate of beta-oxidation in liver, skeletal muscle and brown adipose tissue
additional information
SCD1 deficiency increases the rate of beta-oxidation in liver, skeletal muscle and brown adipose tissue
additional information
SCD1 deficiency increases the rate of beta-oxidation in liver, skeletal muscle and brown adipose tissue
additional information
SCD1 deficiency increases the rate of beta-oxidation in liver, skeletal muscle and brown adipose tissue
additional information
SCD1-deficient mice show significantly higher total and resting oxygen consumption than littermate controls
additional information
SCD1-deficient mice show significantly higher total and resting oxygen consumption than littermate controls
additional information
SCD1-deficient mice show significantly higher total and resting oxygen consumption than littermate controls
additional information
SCD1-deficient mice show significantly higher total and resting oxygen consumption than littermate controls
additional information
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SCD1 knockout mice show reduced levels of fatty acid transport proteins and lipid content on the heart, as well as decreased fatty acid beta-oxidation and a downregulated peroxisome proliferator-activated receptor-alpha, PPARalpha, pathway, the signalling pathways involved in glucose transport are affected, phenotype, overview
additional information
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silencing of SCD1 does not downregulate 3T3-L1 cell differentiation or gene expression, inhibition of adipogenesis caused by SCD2 depletion is associated with a decrease in peroxisome proliferator-activated receptor alpha mRNA and protein, whereas in mature adipocytes loss of SCD2 diminishes PPARalpha protein levels, with little change in mRNA levels and protein translation levels
additional information
generation of global and tissue specific SCD1 knockout mice, phenotypes, detailed overview
additional information
generation of global and tissue specific SCD1 knockout mice, phenotypes, detailed overview
additional information
generation of global and tissue specific SCD1 knockout mice, phenotypes, detailed overview
additional information
generation of global and tissue specific SCD1 knockout mice, phenotypes, detailed overview
additional information
generation of liver-specific SCD3 knockout mice, phenotype. Partial restoration of endogenous palmitoleate levels in the liver through overexpression of mouse wild-type SCD3 isoform
additional information
generation of liver-specific SCD3 knockout mice, phenotype. Partial restoration of endogenous palmitoleate levels in the liver through overexpression of mouse wild-type SCD3 isoform
additional information
generation of liver-specific SCD3 knockout mice, phenotype. Partial restoration of endogenous palmitoleate levels in the liver through overexpression of mouse wild-type SCD3 isoform
additional information
generation of liver-specific SCD3 knockout mice, phenotype. Partial restoration of endogenous palmitoleate levels in the liver through overexpression of mouse wild-type SCD3 isoform
additional information
scd1 gene silencing by siRNA resulting in 90% reduction in scd1 mRNA expression, ceramide spectrum in the mutant, membrane microdomain lipid and acyl chain composition are altered in SCD1 knockdown mutant cells, phenotype, overview. Short range lateral diffusion, using 1-pyrenedecanoic acid, is highly reduced in mutant cell membranes. SCD1 knockout activates the expression of enzymes involved in the remodelling of phospholipids
additional information
siRNA-mediated downregulation of stearoyl-coenzyme A desaturase-1 (SCD1) in diabetic proximal tubular epithelial cells
additional information
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stability and activity of several GFP-fusion mutant enzymes variants, resistance os sensitivity to mycobacterial proteases, overview
additional information
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stability and activity of several GFP-fusion mutant enzymes variants, resistance os sensitivity to mycobacterial proteases, overview
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additional information
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yeast expression strain carries a mutation in the stearoyl-CoA desaturase gene
