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1.14.19.1: stearoyl-CoA 9-desaturase

This is an abbreviated version!
For detailed information about stearoyl-CoA 9-desaturase, go to the full flat file.

Word Map on EC 1.14.19.1

Reaction

stearoyl-CoA
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
oleoyl-CoA
+ 2 ferricytochrome b5 + 2 H2O

Synonyms

ACOD4, acyl coenzyme A desaturase, acyl-CoA desaturase, delta-9 desaturase, DELTA9 desaturase, DELTA9 fatty acid desaturase, DELTA9 terminal desaturase, DELTA9-acyl CoA desaturase, DELTA9-desaturase, DELTA9-fatty-acid desaturase, DELTA9D, DesA3, desaturase 9, Dpu-DELTA9-KPSE, EC 1.14.99.5, eicosatrienoyl-CoA desaturase, FAD9, fatty acid 9-desaturase, fatty acid DELTA9-desaturase, fatty acid desaturase, fatty acyl CoA DELTA9-desaturase, fatty acyl DELTA9-desaturase, fatty acyl-CoA desaturase, hSCD1, hSCD5, long-chain fatty acid DELTA9-desaturase, membrane-bound stearoyl-CoA DELTA9 desaturase, NPVE desaturase, palmitoyl CoA desaturase, palmitoyl-CoA desaturase, SCD, SCD-1, SCD-2, SCD-3, SCD-4, SCD1, SCD2, SCD3, SCD4, SCD5, stearoyl CoA desaturase, stearoyl coenzyme A desaturase, stearoyl coenzyme-A desaturase 1, stearoyl-ACP DELTA9 desaturase, stearoyl-CoA (DELTA8) desaturase, stearoyl-CoA desaturase, stearoyl-CoA desaturase 1, stearoyl-CoA desaturase 2, stearoyl-CoA desaturase enzyme-1, stearoyl-CoA desaturase-1, stearoyl-CoA desaturase-2, stearoyl-CoA desaturase-3, stearoyl-CoA desaturase-4, stearoyl-CoA desaturase-5, stearoyl-CoA desaturase1, stearoyl-CoA desaturase2, stearoyl-coenzyme A desaturase, stearoyl-coenzyme A desaturase-1, stearyl coenzyme A desaturase, stearyl-CoA desaturase, TkSCD-1, TkSCD-2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.1 stearoyl-CoA 9-desaturase

Expression

Expression on EC 1.14.19.1 - stearoyl-CoA 9-desaturase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
C-reactive protein concentrations are positively associated with estimated SCD-1 activity
-
chronic food restriction and chronic food restriction/refeeding cause increased expression
-
dietary saturated fat strongly induces Scd1 expression
-
enzyme SCD1 is 28fold upregulated in enriched liver tumor-initiating cell populations and sporadically expressed in human hepatocellular carcinoma specimens, upregulation of SCD1 of self-renewing liver cancer cells in chemoresistant hepatospheres
hepatic SCD1 expression increases in experimental steatosis resulting from high fat diet and decreases in a methionine-choline-deficient dietary model of steatohepatitis resulting in the latter situation in significantly increased hepatic saturated fatty acid levels
-
higher levels of stearoyl lysophosphatidylcholine and lower levels of oleoyl lysophosphatidylcholine in dextran sulfate sodium-treated mice compared to controls lead to the identification of dextran sulfate sodium-elicited inhibition of SCD1 expression in liver, Citrobacter rodentium-induced colitis and lipopolysaccharide treatment also suppresses SCD1 expression in liver
-
intracerebroventricular glucose administration strongly decreases hepatic Scd1
-
isoform SCD-1 expression is dramatically induced in liver and heart in response to high-carbohydrate diet, SCD-1 expression is also induced by nuclear sterol regulatory element-binding protein-1 via the sterol regulatory element in its promoter, in aortic endothelial cells liver X receptor beta activation increases SCD-1 mRNA and protein expression
-
linolenic acid and eicosapentaenoic acid decrease SCD mRNA (EC50 of 0.50 and 1.67 mM), whereas alpha-linolenic acid does not, GW-9662 at a pan-peroxisome proliferation activator receptor antagonistic dose does not obviate the effects of linolenic acid and eicosapentaenoic acid on SCD mRNA
-
mRNA level increased in prediabetic Zucker diabetic fatty islets
-
mRNA level reduced in diabetic Zucker diabetic fatty islets
-
SCD-1 expression is about 2fold upregulated in coronary artery smooth muscle cells, myotubes, and Hep-G2 cells at 0.5 mM palmitate, SCD-1 is upregulated using 0.01 mM TO-901317 in HAEC cells, inhibition of SCD-1 with cis-10,trans-12-conjugated linoleic acid blocks the upregulating effect of TO-901317
-
SCD-1 is not upregulated in HAEC cells upon palmitate treatment
-
SCD1 expression is induced by palmitate, high SCD1 inducibility is associated with a low inflammatory and endoplasmic reticulum stress response to palmitate exposure
-
the enzyme level is dramatically increased in high-fat diet-fed myeloid differentiation factor 88-deficient mice liver
-
the enzyme level is increased in human lung tumors
-
there is a 53fold increase of SCD transcript expression level between 18 and 36 h during the late trophozoite stage