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1.14.19.20: DELTA7-sterol 5(6)-desaturase

This is an abbreviated version!
For detailed information about DELTA7-sterol 5(6)-desaturase, go to the full flat file.

Word Map on EC 1.14.19.20

Reaction

a DELTA7-sterol
+ 2 ferrocytochrome b5 +
O2
 + 2 H+ =
a DELTA5,7-sterol
 + 2 ferricytochrome b5 + 2 H2O

Synonyms

5-DES, 5alpha-cholest-7-en-3beta-ol:oxygen DELTA5-oxidoreductase, C-5 sterol desaturase, C-5(6) sterol desaturase, Delta-7-sterol 5-desaturase, DELTA7-sterol 5-desaturase, DELTA7-sterol C56-desaturase, DELTA7-sterol DELTA5-dehydrogenase, DELTA7-sterol-C-5-desaturase, DELTA7-sterol-C5 (6)-desaturase, DELTA7-sterol-C5(6)-desaturase, DELTA7-sterol-C5-desaturase, DES5A, Des5Ap, Dhcr7, DWARF7, EC 1.14.21.6, EC 1.3.3.2, ERG 3, ERG3, erg32, Erg3p, FvC5SD, Lathosterol 5-desaturase, lathosterol oxidase, oxidase, lathosterol, Sc5d, SC5DL, SCSD, STE1, sterol C5-desaturase, sterol DELTA5,6-desaturase, sterol DELTA7-reductase, Sterol-C5-desaturase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.20 DELTA7-sterol 5(6)-desaturase

Cloned

Cloned on EC 1.14.19.20 - DELTA7-sterol 5(6)-desaturase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in a Saccharomyces cerevisiae erg3-deficient mutant strain
expressed in an C-5(6) sterol desaturase erg3-deficient mutant of Saccharomyces cerevisia
expressed in an erg3-defective mutant of Saccharomyces crevisiae
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expressed in Arabidopsis thaliana deficient in DELTA7-sterol-C-5-desaturase
-
expressed in Saccharomyces cerevisiae strain erg3
-
expression in null mutant erg3 of Saccharomyces cerevisiae
expression in Saccharomyces cerevisiae erg3 mutant
gene ERG3, DNA and amino acid sequence determination and analysis
gene ERG3, DNA and amino acid sequence determination and analysis, transcriptome analysis
gene Sc5D, located on chromosome 9 exon 4
-
recombinant expression in Schizosaccharomyces pombe imparts increased thermotolerance and also tolerance towards high ethanol concentration and low pH for the transformed cells with an 1.5fold increase in the level of ergosterol and oleic acid. The FvC5SD transcript is 5fold upregulated in growth under low pH condition and 9fold or 5fold at 40°C and 4°C, respectively, when compared to normal growth temperature of 23°C. Susceptibility to cell wall inhibiting drugs like Congo red and Calcoflour white is also found to increase in FvC5SD-expressing Schizosaccharomyces pombe strain, alteration in membrane sterol and fatty acid composition can lead to increase in susceptibility to cell wall inhibiting drugs
wild-type enzyme and ste1 mutant enzyme expressed in Sacharomyces cerevisiae erg3 mutant, wild-type enzyme overexpressed in Arabidopsis ste1 mutant
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