1.14.19.20: DELTA7-sterol 5(6)-desaturase

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For detailed information about DELTA7-sterol 5(6)-desaturase, go to the full flat file.

Reaction

Synonyms

5-DES, 5alpha-cholest-7-en-3beta-ol:oxygen DELTA5-oxidoreductase, C-5 sterol desaturase, C-5(6) sterol desaturase, Delta-7-sterol 5-desaturase, DELTA7-sterol 5-desaturase, DELTA7-sterol C56-desaturase, DELTA7-sterol DELTA5-dehydrogenase, DELTA7-sterol-C-5-desaturase, DELTA7-sterol-C5 (6)-desaturase, DELTA7-sterol-C5(6)-desaturase, DELTA7-sterol-C5-desaturase, DES5A, Des5Ap, Dhcr7, DWARF7, EC 1.14.21.6, EC 1.3.3.2, ERG 3, ERG3, erg32, Erg3p, FvC5SD, Lathosterol 5-desaturase, lathosterol oxidase, oxidase, lathosterol, Sc5d, SC5DL, SCSD, STE1, sterol C5-desaturase, sterol DELTA5,6-desaturase, sterol DELTA7-reductase, Sterol-C5-desaturase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

                1.14.19.20 DELTA7-sterol 5(6)-desaturase

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Results	in table
2	Activating Compound
110	AA Sequence
1	CAS Registry Number
18	Cloned(Commentary)
40	Cofactor
16	Disease/ Diagnostics
14	General Information
1	General Stability
12	IC50 Value
40	Inhibitors
18	KM Value [mM]
21	Localization
4	Metals/Ions
1	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
46	Organism
16	Pathway
2	pH Optimum
56	Protein Variants
2	Purification (Commentary)
3	Reaction
10	Reaction Type
44	Reference
24	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
69	Substrates and Products (Substrate)
1	Subunits
68	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Disease

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Disease on EC 1.14.19.20 - DELTA7-sterol 5(6)-desaturase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Carcinogenesis

Vitamin D3 Produced by Skin Exposure to UVR Inhibits Murine Basal Cell Carcinoma Carcinogenesis.

28774592

Dehydration

FvC5SD overexpression enhances drought tolerance in soybean by reactive oxygen species scavenging and modulating stress-responsive gene expression.

31144112

delta7-sterol 5(6)-desaturase deficiency

Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency.

12812989

Infections

Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity.

29789366

Neoplasms

Delineation of TMPRSS2-ERG splice variants in prostate cancer.

18676740

Prostatic Neoplasms

Delineation of TMPRSS2-ERG splice variants in prostate cancer.

18676740

Smith-Lemli-Opitz Syndrome

Quantitative proteomic analysis of inborn errors of cholesterol synthesis: Identification of altered metabolic pathways in DHCR7 and SC5D deficiency.

20305089

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