1.14.19.20: DELTA7-sterol 5(6)-desaturase
This is an abbreviated version!
For detailed information about DELTA7-sterol 5(6)-desaturase, go to the full flat file.
Word Map on EC 1.14.19.20
-
1.14.19.20
-
ergosterol
-
desaturation
-
fluconazole
-
7-dehydrocholesterol
-
azole
-
desaturases
-
azole-resistant
-
smith-lemli-opitz
-
voriconazole
- 1.14.19.20
- ergosterol
-
desaturation
- fluconazole
- 7-dehydrocholesterol
- azole
-
desaturases
-
azole-resistant
-
smith-lemli-opitz
- voriconazole
Reaction
Synonyms
5-DES, 5alpha-cholest-7-en-3beta-ol:oxygen DELTA5-oxidoreductase, C-5 sterol desaturase, C-5(6) sterol desaturase, Delta-7-sterol 5-desaturase, DELTA7-sterol 5-desaturase, DELTA7-sterol C56-desaturase, DELTA7-sterol DELTA5-dehydrogenase, DELTA7-sterol-C-5-desaturase, DELTA7-sterol-C5 (6)-desaturase, DELTA7-sterol-C5(6)-desaturase, DELTA7-sterol-C5-desaturase, DES5A, Des5Ap, Dhcr7, DWARF7, EC 1.14.21.6, EC 1.3.3.2, ERG 3, ERG3, erg32, Erg3p, FvC5SD, Lathosterol 5-desaturase, lathosterol oxidase, oxidase, lathosterol, Sc5d, SC5DL, SCSD, STE1, sterol C5-desaturase, sterol DELTA5,6-desaturase, sterol DELTA7-reductase, Sterol-C5-desaturase
ECTree
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Reference on EC 1.14.19.20 - DELTA7-sterol 5(6)-desaturase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rahier, A.; Smith, M.; Taton, M.
The role of cytochrome b5 in 4alpha-methyl-oxidation and C5(6) desaturation of plant sterol precursors
Biochem. Biophys. Res. Commun.
236
434-437
1997
Zea mays
Kawata, S.; Traskos, J.M.; Gaylor, J.L.
Microsomal enzymes of cholesterol biosynthesis from lanosterol. Purification and characterization of DELTA 7-sterol 5-desaturase of rat liver microsomes
J. Biol. Chem.
260
6609-6617
1985
Rattus norvegicus
Grinstead, G.F.; Gaylor, J.L.
Total enzymic synthesis of cholesterol from 4,4,14alpha-trimethyl-5alpha-cholesta-8,24-dien-3beta-ol. Solubilization, resolution, and reconstitution of DELTA 7-sterol 5-desaturase
J. Biol. Chem.
257
13937-13944
1982
Rattus norvegicus
Ishibashi, T.; Bloch, K.
Intermembrane transfer of 5alpha-cholest-7-en-3beta-ol. Facilitation by supernatant protein (SCP)
J. Biol. Chem.
256
12962-12967
1981
Rattus norvegicus
Dempsey, M.E.; McCoy, K.E.; Barker, H.N.
Large scale purification and structural characterization of squalene and sterol carrier protein
J. Biol. Chem.
256
1867-1873
1981
Rattus norvegicus
Mitropoulos, K.A.; Gibbons, G.F.
Effect of triarimol on cholesterol biosynthesis in rat-liver subcellular
Biochem. Biophys. Res. Commun.
71
892-900
1976
Rattus norvegicus
Husselstein, T.; Schaller, H.; Gachotte, D.; Benveniste, P.
DELTA7-sterol-C5-desaturase: molecular characterization and functional expression of wild-type and mutant alleles
Plant Mol. Biol.
39
891-906
1999
Arabidopsis thaliana, Saccharomyces cerevisiae, Nicotiana tabacum, Zea mays
Nishi, S.; Nishino, H.; Ishibashi, T.
cDNA cloning of the mammalian sterol C5-desaturase and the expression in yeast mutant
Biochim. Biophys. Acta
1490
106-108
2000
Homo sapiens, Mus musculus
Taton, M.; Husselstein, T.; Benveniste, P.; Rahier, A.
Role of highly conserved residues in the reaction catalyzed by recombinant DELTA7-sterol-C5(6)-desaturase studied by site-directed mutagenesis
Biochemistry
39
701-711
2000
Arabidopsis thaliana (Q39208), Arabidopsis thaliana
Rahier, A.; Benveniste, P.; Husselstein, T.; Taton, M.
Biochemistry and site-directed mutational analysis of DELTA7-sterol-C5(6)-desaturase
Biochem. Soc. Trans.
28
799-803
2000
Zea mays
Sugawara, T.; Fujimoto, Y.; Ishibashi, T.
Molecular cloning and structural analysis of human sterol C5 desaturase
Biochim. Biophys. Acta
1533
277-284
2001
Homo sapiens
Rahier, A.
Deuterated DELTA7-cholestenol analogues as mechanistic probes for wild-type and mutated DELTA7-sterol-C5(6)-desaturase
Biochemistry
40
256-267
2001
Arabidopsis thaliana, Zea mays
Krakowiak, P.A.; Wassif, C.A.; Kratz, L.; Cozma, D.; Kovarova, M.; Harris, G.; Grinberg, A.; Yang, Y.; Hunter, A.G.; Tsokos, M.; Kelley, R.I.; Porter, F.D.
Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency
Hum. Mol. Genet.
12
1631-1641
2003
Mus musculus
Lin, X.; Chen, Z.; Yue, P.; Averna, M.R.; Ostlund, R.E.; Watson, M.A.; Schonfeld, G.
A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation
Am. J. Physiol. Gastrointest. Liver Physiol.
290
G1170-G1176
2006
Mus musculus (O88822), Mus musculus
Giera, M.; Renard, D.; Ploessl, F.; Bracher, F.
Lathosterol side chain amides—a new class of human lathosterol oxidase inhibitors
Steroids
73
299-308
2008
Homo sapiens
Rossi, M.; DArmiento, M.; Parisi, I.; Ferrari, P.; Hall, C.M.; Cervasio, M.; Rivasi, F.; Balli, F.; Vecchione, R.; Corso, G.; Andria, G.; Parenti, G.
Clinical phenotype of lathosterolosis
Am. J. Med. Genet. A
143A
2371-2381
2007
Homo sapiens
Nusblat, A.D.; Najle, S.R.; Tomazic, M.L.; Uttaro, A.D.; Nudel, C.B.
C-5(6) sterol desaturase from Tetrahymena thermophila: Gene identification and knockout, sequence analysis, and comparison to other C-5(6) sterol desaturases
Eukaryot. Cell
8
1287-1297
2009
Tetrahymena thermophila (C4PFX1), Tetrahymena thermophila, Tetrahymena thermophila CU428 (C4PFX1)
Acimovic, J.; Korosec, T.; Seliskar, M.; Bjorkhem, I.; Monostory, K.; Szabo, P.; Pascussi, J.M.; Belic, A.; Urleb, U.; Kocjan, D.; Rozman, D.
Inhibition of human sterol DELTA7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis
Drug Metab. Dispos.
39
39-46
2011
Homo sapiens
Jiang, X.S.; Backlund, P.S.; Wassif, C.A.; Yergey, A.L.; Porter, F.D.
Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency
Mol. Cell. Proteomics
9
1461-1475
2010
Mus musculus
Silvestro, D.; Andersen, T.; Schaller, H.; Jensen, P.
Plant sterol metabolism. delta7-Sterol-C5-desaturase (STE1/DWARF7), delta5,7-sterol-delta7-reductase (DWARF5) and delta24-sterol-delta24-reductase (DIMINUTO/DWARF1) show multiple subcellular localizations in Arabidopsis thaliana (Heynh) L
PLoS ONE
8
e56429
2013
Arabidopsis thaliana
Chau, A.; Gurnani, M.; Hawkinson, R.; Laverdiere, M.; Cacciapuoti, A.; McNicholas, P.
Inactivation of sterol DELTA5,6-desaturase attenuates virulence in Candida albicans
Antimicrob. Agents Chemother.
49
3646-3651
2005
Candida albicans (O93875), Candida albicans
Taton, M.; Rahier, A.
Plant sterol biosynthesis: Identification and characterization of higher plant DELTA7-sterol C5(6)-desaturase
Arch. Biochem. Biophys.
325
279-288
1996
Zea mays
Nishino, H.; Nakaya, J.; Nishi, S.; Kurosawa, T.; Ishibashi, T.
Temperature-induced differential kinetic properties between an initial burst and the following steady state in membrane-bound enzymes: studies on lathosterol 5-desaturase
Arch. Biochem. Biophys.
339
298-304
1997
Rattus norvegicus
Nishino, H.; Nishi, S.; Ishibashi, T.
Nine of ten histidine residues, located in three conserved clusters, are required for mammalian sterol C5-desaturase activity
Biomed. Res.
24
99-106
2003
Homo sapiens (O75845)
-
Arthington, B.A.; Bennett, L.G.; Skatrud, P.L.; Guynn, C.J.; Barbuch, R.J.; Ulbright, C.E.; Bard, M.
Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase
Gene
102
39-44
1991
Saccharomyces cerevisiae
Morio, F.; Pagniez, F.; Lacroix, C.; Miegeville, M.; Le pape, P.
Amino acid substitutions in the Candida albicans sterol DELTA5,6-desaturase (Erg3p) confer azole resistance: Characterization of two novel mutants with impaired virulence
J. Antimicrob. Chemother.
67
2131-2138
2012
Candida albicans (J7FE12)
Honjo, K.; Ishibashi, T.; Imai, Y.
Partial purification and characterization of lathosterol 5-desaturase from rat liver microsomes
J. Biochem.
97
955-959
1985
Rattus norvegicus
Takakuwa, Y.; Nishino, H.; Ishibe, Y.; Ishibashi, T.
Properties and kinetics of membrane-bound enzymes when both the enzyme and substrate are components of the same microsomal membrane. Studies on lathosterol 5-desaturase
J. Biol. Chem.
269
27889-27893
1994
Rattus norvegicus
Gachotte, D.; Meens, R.; Benveniste, P.
An Arabidopsis mutant deficient in sterol biosynthesis: heterologous complementation by ERG 3 encoding a DELTA7-sterol-C-5-desaturase from yeast
Plant J.
8
407-416
1995
Saccharomyces cerevisiae
Gachotte, D.; Husselstein, T.; Bard, M.; Lacroute, F.; Benveniste, P.
Isolation and characterization of an Arabidopsis thaliana cDNA encoding a DELTA7-sterol-C-5-desaturase by functional complementation of a defective yeast mutant
Plant J.
9
391-398
1996
Arabidopsis thaliana
Poklepovich, T.J.; Rinaldi, M.A.; Tomazic, M.L.; Favale, N.O.; Turkewitz, A.P.; Nudel, C.B.; Nusblat, A.D.
The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae
Steroids
77
1313-1320
2012
Tetrahymena thermophila (C4PFX1), Tetrahymena thermophila, Tetrahymena thermophila CU428 (C4PFX1)
Rybak, J.; Dickens, C.; Parker, J.; Caudle, K.; Manigaba, K.; Whaley, S.; Nishimoto, A.; Luna-Tapia, A.; Roy, S.; Zhang, Q.; Barker, K.; Palmer, G.; Sutter, T.; Homayouni, R.; Wiederhold, N.; Kelly, S.; Rogers, P.
Loss of C-5 sterol desaturase activity results in increased resistance to azole and echinocandin antifungals in a clinical isolate of candida parapsilosis
Antimicrob. Agents Chemother.
61
e00651-17
2017
Candida parapsilosis (A0A1L2BH72), Candida parapsilosis, Candida albicans (Q59VG6), Candida albicans, Candida parapsilosis CDC317 (A0A1L2BH72)
Makarova, A.M.; Pasta, S.; Watson, G.; Shackleton, C.; Epstein, E.H.
Attenuation of UVR-induced vitamin D3 synthesis in a mouse model deleted for keratinocyte lathosterol 5-desaturase
J. Steroid Biochem. Mol. Biol.
171
187-194
2017
Mus musculus, Mus musculus C57Bl/6N (JM8A3.N1)
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