1.14.19.30: acyl-lipid (8-3)-desaturase
This is an abbreviated version!
For detailed information about acyl-lipid (8-3)-desaturase, go to the full flat file.
Word Map on EC 1.14.19.30
-
1.14.19.30
-
arachidonic
-
polyunsaturated
-
linoleic
-
desaturation
-
phospholipid
-
desaturases
-
pufas
-
delta-6
-
docosahexaenoic
-
eicosapentaenoic
-
dihomo-gamma-linolenic
-
delta6-desaturase
-
elongase
-
monounsaturated
-
alpha-linolenic
-
gamma-linolenic
-
stearoyl-coa
-
mortierella
-
omega-6
-
alpina
-
8-hydroxyoctanoic
-
lc-pufas
-
sesamin
-
eicosatrienoic
-
medicine
-
agriculture
-
diagnostics
- 1.14.19.30
-
arachidonic
-
polyunsaturated
-
linoleic
-
desaturation
- phospholipid
-
desaturases
-
pufas
-
delta-6
-
docosahexaenoic
-
eicosapentaenoic
-
dihomo-gamma-linolenic
- delta6-desaturase
- elongase
-
monounsaturated
-
alpha-linolenic
-
gamma-linolenic
- stearoyl-coa
-
mortierella
-
omega-6
- alpina
-
8-hydroxyoctanoic
-
lc-pufas
- sesamin
-
eicosatrienoic
- medicine
- agriculture
- diagnostics
Reaction
Synonyms
acyl-lipid 5-desaturase, AL21, C20 DELTA5cis-desaturase, D5b, D5D, D5des, delta 5 desaturase, DELTA 5 fatty acid desaturase, delta-5 desaturase, DELTA-5-desaturase, DELTA5 desaturase, DELTA5 fatty acid desaturase, DELTA5-Des, DELTA5-desaturase, DELTA5-fatty acid desaturase, DELTA5-fatty-acid desaturase, DES5, desat7, FadA, FadB, FADS1, fads2b, FAT-4, fatty acid desaturase, PPDES5, PsD5Des
ECTree
1.14.19.30 acyl-lipid (8-3)-desaturaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.14.19.30 - acyl-lipid (8-3)-desaturase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(7Z)-octadec-7-enoic acid + ferrocytochrome b5 + O2 + H+
(5Z,7Z)-octadeca-5,7-dienoic acid + ferricytochrome b5 + H2O
-
5% conversion
-
-
?
(8Z,11Z,14Z)-eicosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-eicosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
(8Z,11Z,14Z,17Z)-eicosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-eicosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
best substrate
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
di-homo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
55% conversion
-
-
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
eicosa-11,14,17-trienoate + acceptor + O2 + H+
eicosa-5,11,14,17-tetraenoate + ?
-
i.e. juniperoate
-
?
eicosa-11,14,17-trienoic acid + acceptor + O2 + H+
eicosa-5,11,14,17-tetraenoic acid + ?
-
-
i.e. juniperoic acid
-
?
eicosa-11,14,17-trienoyl-CoA + acceptor + O2 + H+
eicosa-5,11,14,17-tetraenoyl-CoA + ?
-
-
i.e. juniperoyl-CoA
-
?
eicosa-11,14-dienoate + acceptor + O2 + H+
eicosa-5,11,14-trienoate + ?
-
i.e. sciadonoate
-
?
eicosa-11,14-dienoic acid + acceptor + O2 + H+
eicosa-5,11,14-trienoic acid + ?
-
-
i.e. sciadonoic acid
-
?
eicosa-11,14-dienoyl-CoA + acceptor + O2 + H+
eicosa-5,11,14-trienoyl-CoA + ?
-
-
i.e. sciadonoyl-CoA
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
-
-
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
(8Z,11Z,14Z)-icosa-8,11,14-trienoate i.e. di-homo-gamma-linolenate. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
(8Z,11Z,14Z)-icosa-8,11,14-trienoate i.e. di-homo-gamma-linolenate. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
(8Z,11Z,14Z)-icosa-8,11,14-trienoate i.e. di-homo-gamma-linolenate. Expression of the enzyme in Saccharomyces cerevisiae results in the production of the DELTA5-containing fatty acid arachidonic acid in cells that are provided di-homo-gamma-linolenic acid
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoate i.e. arachidonate
-
?
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
?
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
-
?
an (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+
a (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-[glycerolipid] + ferricytochrome b5 + 2 H2O
-
-
-
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
-
-
-
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
-
-
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
-
-
?
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
arachidonic acid + ferricytochrome b5 + H2O
-
-
-
-
?
linoleic acid + ferrocytochrome b5 + O2 + H+
pinolenic acid + ferricytochrome b5 + H2O
-
-
pinoleinic acid is DELTA5,9,12-18:3
-
?
linoleic acid + ferrocytochrome b5 + O2 + H+
pinolenic acid + ferricytochrome b5 + H2O
-
-
pinoleinic acid is DELTA5,9,12-18:3
-
?
oleic acid + ferrocytochrome b5 + O2 + H+
taxoleic acid + ferricytochrome b5 + H2O
-
-
taxoleic acid is DELTA5,9-18:2
-
?
oleic acid + ferrocytochrome b5 + O2 + H+
taxoleic acid + ferricytochrome b5 + H2O
-
-
taxoleic acid is DELTA5,9-18:2
-
?
additional information
?
-
-
the enzyme catalyzes the introduction of a cis-double bond at the DELTA5 position of a wide range of saturated fatty acids including tetradecanoic acid, pentadecanoic acid, octadecanoic acid, 14-methyl pentadecanoic acid, 15-methylhexadecanoic acid, and 14-methylhexadecanoic acid
-
-
?
additional information
?
-
-
the enzyme catalyzes the introduction of a cis-double bond at the DELTA5 position of a wide range of saturated fatty acids including tetradecanoic acid, pentadecanoic acid, octadecanoic acid, 14-methyl pentadecanoic acid, 15-methylhexadecanoic acid, and 14-methylhexadecanoic acid
-
-
?
additional information
?
-
-
no activity with 20:1DELTA11, 18:2DELTA9,12, and 18:3DELTA9,12,15
-
-
?
additional information
?
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
-
-
?
additional information
?
-
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
-
-
?
additional information
?
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
-
-
?
additional information
?
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
-
-
?
additional information
?
-
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8-C16)
-
-
?
additional information
?
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8C16)
-
-
?
additional information
?
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8C16)
-
-
?
additional information
?
-
-
the encoded enzyme displays DELTA5-desaturase activity on myristic acid to produce Z5-14:acyl, when heterologously expressed in yeast, but is not able to desaturate any other fatty acid (C8C16)
-
-
?
additional information
?
-
the enzyme can desaturate C20:4(n-3) and C20:3(n-6) to C20:5(n-3) and C20:4(n-6) respectively, displaying a DELTA5 desaturation activity
-
-
?
additional information
?
-
no activity with 18:2(DELTA9,12), 18:3n-3(DELTA9,12,15), or 22:5n-3(DELTA7,11,13,16,19)
-
-
?
additional information
?
-
expression of the fasd2b in yeast generates a protein that converts eicosatetraenoic acid (20:4n-3) to eicosapentaenoic acid (20:5n-3), and functions as a monofunctional DELTA5 desaturase. The enzyme does not show any DELTA8 desaturase activity
-
-
?
additional information
?
-
-
expression of the fasd2b in yeast generates a protein that converts eicosatetraenoic acid (20:4n-3) to eicosapentaenoic acid (20:5n-3), and functions as a monofunctional DELTA5 desaturase. The enzyme does not show any DELTA8 desaturase activity
-
-
?
additional information
?
-
-
no products are detected with the C18 fatty acid linoleic and gamma-linolenic acids or with the C22 fatty acid adrenic and docosapentaenoic acids
-
-
?
