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1.14.19.4: acyl-lipid (11-3)-desaturase

This is an abbreviated version!
For detailed information about acyl-lipid (11-3)-desaturase, go to the full flat file.

Word Map on EC 1.14.19.4

Reaction

an (11Z,14Z)-icosa-11,14-dienoyl-[glycerolipid]
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid]
+ 2 ferricytochrome b5 + 2 H2O

Synonyms

AtSLD1, AtSLD2, Boofd8, Ca-SLDp, D8A, DELTA6-desaturase, DELTA8 acyl-CoA-dependent desaturase, DELTA8 desaturase, DELTA8 sphingobase desaturase, Delta8 sphingolipid desaturase, DELTA8-desaturase, DELTA8-fatty-acid desaturase, DELTA8-sphingolipid desaturase, FADS2, SLD, SlSLD, sphingolipid delta8 desaturase, sphingolipid DELTA8 LCB desaturase, sphingolipid DELTA8 long-chain base desaturase, sphingolipid DELTA8-desaturase, TpdesB

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.4 acyl-lipid (11-3)-desaturase

Engineering

Engineering on EC 1.14.19.4 - acyl-lipid (11-3)-desaturase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A44G
-
expressed in yeast, 2-fold higher activity toward 20:2 (n-6), but nor alternation in activity towards 20:3 (n-3) in comparison with the wild-type
D208R
-
inactive
D210R
-
inactive
F59R
-
the mutant shows markedly decreased activity compared to the wild type enzyme
G28R
-
the mutant shows decreased activity compared to the wild type enzyme
G368R
-
inactive
G52R
-
the mutant shows wild type activity
H63R
-
inactive
L369A
-
the mutant shows markedly decreased activity compared to the wild type enzyme
L71R
-
the mutant shows wild type activity
N203R
-
inactive
Q372H
-
the mutant shows markedly decreased activity compared to the wild type enzyme
T56R
-
the mutant shows decreased activity compared to the wild type enzyme
W190A
-
the mutant shows markedly decreased activity compared to the wild type enzyme
W345A
-
the mutant shows markedly decreased activity compared to the wild type enzyme
Y31A
-
the mutant shows decreased activity compared to the wild type enzyme
additional information