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1.14.19.47: acyl-lipid (9-3)-desaturase

This is an abbreviated version!
For detailed information about acyl-lipid (9-3)-desaturase, go to the full flat file.

Word Map on EC 1.14.19.47

Reaction

a linoleoyl-[glycerolipid]
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a gamma-linolenoyl-[glycerolipid]
+
ferricytochrome b5
+ 2 H2O

Synonyms

acyl-lipid 6-desaturase, AL1, D-6 desaturase, D6D, D6Des, DELTA 6-desaturase, DELTA-6 desaturase, DELTA-6-desaturase, DELTA6 desaturase, DELTA6-desaturase, DELTA6-fatty acid desaturase, DELTA6fad, DES6, FADS2, fadsd6, fatty acyl DELTA6 desaturase, PyDes6

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.47 acyl-lipid (9-3)-desaturase

Engineering

Engineering on EC 1.14.19.47 - acyl-lipid (9-3)-desaturase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D169V/T275A
the mutant has little effect on the D6-desaturation activity of the enzyme
L14P
the mutant shows dramatically reduced activity compared to the wild type enzyme
L224S
the mutant shows dramatically reduced activity compared to the wild type enzyme
L371F
the mutant shows dramatically reduced activity compared to the wild type enzyme
S205N
the mutant has little effect on the D6-desaturation activity of the enzyme
S301P
the mutant shows dramatically reduced activity compared to the wild type enzyme
S391P
the mutant shows dramatically reduced activity compared to the wild type enzyme
V137A
the mutant shows dramatically reduced activity compared to the wild type enzyme