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1.14.19.47: acyl-lipid (9-3)-desaturase

This is an abbreviated version!
For detailed information about acyl-lipid (9-3)-desaturase, go to the full flat file.

Word Map on EC 1.14.19.47

Reaction

a linoleoyl-[glycerolipid]
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a gamma-linolenoyl-[glycerolipid]
+
ferricytochrome b5
+ 2 H2O

Synonyms

acyl-lipid 6-desaturase, AL1, D-6 desaturase, D6D, D6Des, DELTA 6-desaturase, DELTA-6 desaturase, DELTA-6-desaturase, DELTA6 desaturase, DELTA6-desaturase, DELTA6-fatty acid desaturase, DELTA6fad, DES6, FADS2, fadsd6, fatty acyl DELTA6 desaturase, PyDes6

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.47 acyl-lipid (9-3)-desaturase

Expression

Expression on EC 1.14.19.47 - acyl-lipid (9-3)-desaturase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after adriamycin treatment, enzyme activity increases in polyenylphosphatidylcholine-fed and trilinolein-fed rats
-
expression of DELTA6fad is significantly affected by dietary lipid and, especially, fatty acid composition, with highest expression of mRNA in liver of fish fed a diet with a ratio of 18:3n-3/18:2n-6 of 1.72:1
liver gene expression of FADS2 is up-regulated in groups enriched in C16:0, C18:0 and C18:1n-9 respectively but not in the group enriched in C18:3n-3 compared to groups with high n-3 LC-PUFA contents
neuronal differentiation of Y-79 cells causes a great increase in enzyme activity
-
replacement of fish oil with linseed oil increases the expression of DELTA6 fad mRNA in liver, muscle and intestine but no significant difference is found in the brain
the FADS2 gene expression regulated by dietary fatty acids is significantly negatively correlated with the methylation rate of putative FADS2 gene promoter