1.14.19.8: pentalenolactone synthase

This is an abbreviated version!
For detailed information about pentalenolactone synthase, go to the full flat file.

Reaction

+ 2 reduced ferredoxin + 2 H+ =

+ 2 oxidized ferredoxin + 2 H2O

Synonyms

CYP161C2, EC 1.3.7.10, penM, pntM

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

1.14.19.8 pentalenolactone synthase

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Results	in table
65	AA Sequence
3	Cloned(Commentary)
4	Cofactor
1	Crystallization (Commentary)
4	Expression
2	General Information
7	kcat/KM [mM/s]
10	KM Value [mM]
1	Metals/Ions
4	Natural Substrates/ Products (Substrates)
20	Organism
4	Pathway
9	PDB ID
1	pH Optimum
8	Protein Variants
3	Purification (Commentary)
2	Reaction
10	Reference
11	Substrates and Products (Substrate)
5	Subunits
12	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
9	Turnover Number [1/s]

Reference

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Reference on EC 1.14.19.8 - pentalenolactone synthase

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718843

Tetzlaff, C.N.; You, Z.; Cane, D.E.; Takamatsu, S.; Omura, S.; Ikeda, H.

A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis

Biochemistry

6179-6186

2006

Streptomyces avermitilis

16681390

719654

Zhu, D.; Seo, M.J.; Ikeda, H.; Cane, D.E.

Genome mining in Streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone

J. Am. Chem. Soc.

133

2128-2131

2011

Streptomyces arenae, Streptomyces exfoliatus, Streptomyces exfoliatus UC5319, Streptomyces arenae TUE469

21284395

727767

Zhu, D.; Wang, Y.; Zhang, M.; Ikeda, H.; Deng, Z.; Cane, D.E.

Product-mediated regulation of pentalenolactone biosynthesis in Streptomyces species by the MarR/SlyA family activators PenR and PntR

J. Bacteriol.

195

1255-1266

2013

Streptomyces arenae, Streptomyces exfoliatus, Streptomyces exfoliatus UC5319, Streptomyces arenae TUE469

23316039

745166

Duan, L.; Jogl, G.; Cane, D.

The cytochrome P450-catalyzed oxidative rearrangement in the final step of pentalenolactone biosynthesis substrate structure determines mechanism

J. Am. Chem. Soc.

138

12678-12689

2016

Streptomyces arenae (E3VWI3), Streptomyces arenae

27588339