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1.14.20.3: (5R)-carbapenem-3-carboxylate synthase

This is an abbreviated version!
For detailed information about (5R)-carbapenem-3-carboxylate synthase, go to the full flat file.

Word Map on EC 1.14.20.3

Reaction

(3S,5S)-carbapenam-3-carboxylate
+
2-oxoglutarate
+
O2
=
(5R)-carbapen-2-em-3-carboxylate
+
succinate
+
CO2
+
H2O

Synonyms

carbapenem synthase, CarC

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated
                1.14.20.3 (5R)-carbapenem-3-carboxylate synthase

Natural Substrates Products

Natural Substrates Products on EC 1.14.20.3 - (5R)-carbapenem-3-carboxylate synthase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(3S,5S)-carbapen-2-am-3-carboxylate + 2-oxoglutarate + O2
(5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O
show the reaction diagram
-
the enzyme is involved in the biosynthesis of (5R)-carbapen-2-em-3-carboxylic acid the simplest structurally among the naturally occurring carbapenem beta-lactam antibiotics
-
-
?
(3S,5S)-carbapenam-3-carboxylate + 2-oxoglutarate + O2
(5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O
show the reaction diagram
-
-
-
-
?