Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.99.1: prostaglandin-endoperoxide synthase

This is an abbreviated version!
For detailed information about prostaglandin-endoperoxide synthase, go to the full flat file.

Word Map on EC 1.14.99.1

Reaction

arachidonate
+
reduced acceptor
 + 2 O2 =
prostaglandin H2
 +
acceptor
 +
H2O

Synonyms

(PG)H synthase, COX, COX-1, COX-2, COX1, Cox2, cyclooxygenase, cyclooxygenase 1, cyclooxygenase 2, cyclooxygenase-1, cyclooxygenase-1b, cyclooxygenase-2, cycloxigenase-2, fatty acid cyclooxygenase, hPGHS-1, hPGHS-2, oPGHS-1, PG G/H synthase 2, PG H synthase, PG synthetase, PG-endoperoxide synthase 2, PG-endoperoxide synthetase, PGH-synthase, PGHS, PGHS isoform-1, PGHS-1, PGHS-2, PHS, PHS-1, PHS-2, prostagladin-H synthase, prostaglandin endoperoxide H synthase, prostaglandin endoperoxide H synthase 1, prostaglandin endoperoxide H synthase 2, prostaglandin endoperoxide H synthase-1, prostaglandin endoperoxide H2 synthase-2, prostaglandin endoperoxide synthase, prostaglandin endoperoxide synthase 2, prostaglandin endoperoxide synthase-1, prostaglandin endoperoxide synthase-2, prostaglandin endoperoxide synthetase, prostaglandin G/H synthase, prostaglandin G/H synthase-2, prostaglandin H synthase, prostaglandin H synthase-1, prostaglandin H synthase-2, prostaglandin H2 synthase, prostaglandin H2 synthase-1, prostaglandin synthase, prostaglandin synthase-2, prostaglandin synthetase, prostaglandin-endoperoxide synthase, prostaglandin-endoperoxide synthase 1, prostaglandin-endoperoxide synthase 2, prostaglandin-H-synthase, prostaglandin-H-synthase 1, prostaglandin-H-synthase 2, PTGS 2, PTGS-1, PTGS-2, PTGS1, PTGS2, putative cyclooxygenase-3, synthase, prostaglandin, tPGHS-1, tPGHS-2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.99 Miscellaneous
                1.14.99.1 prostaglandin-endoperoxide synthase

Expression

Expression on EC 1.14.99.1 - prostaglandin-endoperoxide synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
0.1 and 0.001 mM lysophosphatidic acid increases PTGS2 mRNA abundance in the uterine endometrium, the lysophosphatidic acid-induced increase of PTGS2 expression is reduced by cotreatment with Ki-16425
-
brainstem PGHS-1 exhibits robust increases in mRNA postpartum, cerebellar PGHS-1 mRNA is upregulated at 120 days of gestational age
downregulation enzyme transcription is observed in oxytocin-treated mares
-
isozyme Ptgs2 transcript level significantly increases at 2 and 4 h after the deciduogenic stimulus with sesame oil is given, and the levels return to prestimulated levels at 8, 16, and 32 h. In contrast to isoform PTGS1 protein levels, PTGS2 protein is significantly higher at 8 h and remains elevated at 16 and 32 h. PTGS2 protein levels are significantly higher in stimulated endometrium at 8 and 32 h than in nonstimulated endometrium
luteinized hormone induces prostaglandin-endoperoxide synthase 2 expression in periovulatory granulosa cells, the induction in part results from Runt-related transcription factor 1-mediated transactivation of the Ptgs2 promoter
-
seminal plasma induces prostaglandin-endoperoxide synthase 2 expression in immortalized human vaginal cells, involvement of semen prostaglandin E2 in PTGS2 upregulation. Expression of prostaglandin-endoperoxide synthase 2, i.e. cyclooxygenase 2, in human vaginal cells in response to toll-like receptor ligands and other proinflammatory stimuli. Seminal prostaglandin-E2 is one of the major factors in PTGS2 induction
the hippocampus exhibits decreases in PGHS-1 mRNA after 80 days of gestational age
the hippocampus exhibits increases in PGHS-2 mRNA after 80 days of gestational age, brainstem and cortex PGHS-2 exhibit robust increases in mRNA postpartum, cerebellar PGHS-2 mRNA is upregulated at 120 days of gestational age
transplantation of hepatocytes induces hepatic expression of prostaglandin-endoperoxide synthase isoform 1 (5fold)
transplantation of hepatocytes induces hepatic expression of prostaglandin-endoperoxide synthase isoform 2 (2.8fold)
when NCI-H292 cells are transfected with E2F1 siRNA, PTGS2 expression is attenuated