1.14.99.12: androst-4-ene-3,17-dione monooxygenase

This is an abbreviated version!
For detailed information about androst-4-ene-3,17-dione monooxygenase, go to the full flat file.

Word Map on EC 1.14.99.12

1.14.99.12

putida

hydroxylases

toluene

catechol

alpha-hydroxylase

Reaction

Synonyms

4-androstene-3,17-dione monooxygenase, androst-4-ene-3,17-dione 17-oxidoreductase, androst-4-ene-3,17-dione hydroxylase, androstene-3,17-dione hydroxylase, androstenedione monooxygenase, oxygenase, androstenedione mono-

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.99 Miscellaneous

1.14.99.12 androst-4-ene-3,17-dione monooxygenase

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Results	in table
1	CAS Registry Number
2	Cofactor
11	IC50 Value
17	Inhibitors
2	KM Value [mM]
1	Localization
1	Natural Substrates/ Products (Substrates)
12	Organism
1	Pathway
1	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
3	Reaction Type
12	Reference
3	Source Tissue
12	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.14.99.12 - androst-4-ene-3,17-dione monooxygenase

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0.026 - 0.047

5alpha-androstane-17beta-ol

3 entries

0.071

5alpha-androstane-3beta-ol

Rattus norvegicus

exhibits an IC50 of 0.11 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.071 mM against androstendione 16alpha-hydroxylase activity

438366

0.12 - 0.14

5alpha-androstane-3beta-ol-17-one

2 entries

0.065 - 0.11

5beta-androstane-17beta-ol

2 entries

0.084

5beta-androstane-3-one-17-one

Rattus norvegicus

exhibits an IC50 of 0.084 mM against androstendione 7alpha-hydroxylase activity

438366

0.007

5beta-androstane-3beta-ol

Rattus norvegicus

exhibits an IC50 of 0.027 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.007 mM against androstendione 16alpha-hydroxylase activity

438366

0.095

5beta-androstane-3beta-ol-17-one

Rattus norvegicus

exhibits an IC50 of 0.095 mM against androstendione 16alpha-hydroxylase activity

438366