1.14.99.12: androst-4-ene-3,17-dione monooxygenase

This is an abbreviated version!
For detailed information about androst-4-ene-3,17-dione monooxygenase, go to the full flat file.

Reaction

Synonyms

4-androstene-3,17-dione monooxygenase, androst-4-ene-3,17-dione 17-oxidoreductase, androst-4-ene-3,17-dione hydroxylase, androstene-3,17-dione hydroxylase, androstenedione monooxygenase, oxygenase, androstenedione mono-

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.99 Miscellaneous

                1.14.99.12 androst-4-ene-3,17-dione monooxygenase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	CAS Registry Number
2	Cofactor
11	IC50 Value
17	Inhibitors
2	KM Value [mM]
1	Localization
1	Natural Substrates/ Products (Substrates)
12	Organism
1	Pathway
1	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
3	Reaction Type
12	Reference
3	Source Tissue
12	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Substrates Products on EC 1.14.99.12 - androst-4-ene-3,17-dione monooxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Substrate/Product Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

androst-4-ene-3,17-dione + AH2 + O2

14alpha-hydroxyandrost-4-ene-3,17-dione + 14alpha,17beta-dihydroxyandrost-4-en-3-one + 7alpha,17beta-dihydroxyandrost-4-en-3-one + A + H2O

2 entries

androst-4-ene-3,17-dione + AH2 + O2

14alpha-hydroxyandrost-4-ene-3,17-dione + 6beta-hydroxyandrost-4-ene-3,17-dione + A + H2O

2 entries

androst-4-ene-3,17-dione + AH2 + O2

17beta-hydroxyandrost-4-en-3-one + 11beta-hydroxyandrost-4-ene-3,17-dione + 17alpha-oxa-D-homo-androst-4-ene-3,17-dione + A + H2O

2 entries

androst-4-ene-3,17-dione + AH2 + O2

17beta-hydroxyandrost-4-en-3-one + 14alpha-hydroxyandrost-4-ene-3,17-dione + 11alpha-hydroxyandrost-4-ene-3,17-dione + 15beta,17beta-dihydroxyandrost-4-en-3-one + 11alpha,17beta-dihydroxyandrost-4-en-3-one + 15alpha,17beta-dihydroxyandrost-4-en-3-one + A + H2O

2 entries

androst-4-ene-3,17-dione + AH2 + O2

3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + A + H2O

2 entries

androst-4-ene-3,17-dione + NADPH + O2

3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + NADP+ + H2O

2 entries

androst-4-ene-3,17-dione + AH2 + O2

14alpha-hydroxyandrost-4-ene-3,17-dione + 14alpha,17beta-dihydroxyandrost-4-en-3-one + 7alpha,17beta-dihydroxyandrost-4-en-3-one + A + H2O

Mucor hiemalis

-

-

745443

-

-

?

androst-4-ene-3,17-dione + AH2 + O2

14alpha-hydroxyandrost-4-ene-3,17-dione + 14alpha,17beta-dihydroxyandrost-4-en-3-one + 7alpha,17beta-dihydroxyandrost-4-en-3-one + A + H2O

Mucor hiemalis MRC 70325

-

-

745443

-

-

?

androst-4-ene-3,17-dione + AH2 + O2

14alpha-hydroxyandrost-4-ene-3,17-dione + 6beta-hydroxyandrost-4-ene-3,17-dione + A + H2O

Aspergillus wentii

-

-

745443

-

-

?

androst-4-ene-3,17-dione + AH2 + O2

14alpha-hydroxyandrost-4-ene-3,17-dione + 6beta-hydroxyandrost-4-ene-3,17-dione + A + H2O

Aspergillus wentii MRC 200316

-

-

745443

-

-

?

androst-4-ene-3,17-dione + AH2 + O2

17beta-hydroxyandrost-4-en-3-one + 11beta-hydroxyandrost-4-ene-3,17-dione + 17alpha-oxa-D-homo-androst-4-ene-3,17-dione + A + H2O

Aspergillus tamarii

-

-

745443

-

-

?

androst-4-ene-3,17-dione + AH2 + O2

17beta-hydroxyandrost-4-en-3-one + 11beta-hydroxyandrost-4-ene-3,17-dione + 17alpha-oxa-D-homo-androst-4-ene-3,17-dione + A + H2O

Aspergillus tamarii MRC 72400

-

-

745443

-

-

?

androst-4-ene-3,17-dione + AH2 + O2

17beta-hydroxyandrost-4-en-3-one + 14alpha-hydroxyandrost-4-ene-3,17-dione + 11alpha-hydroxyandrost-4-ene-3,17-dione + 15beta,17beta-dihydroxyandrost-4-en-3-one + 11alpha,17beta-dihydroxyandrost-4-en-3-one + 15alpha,17beta-dihydroxyandrost-4-en-3-one + A + H2O

Aspergillus candidus

-

-

745443

-

-

?

androst-4-ene-3,17-dione + AH2 + O2

17beta-hydroxyandrost-4-en-3-one + 14alpha-hydroxyandrost-4-ene-3,17-dione + 11alpha-hydroxyandrost-4-ene-3,17-dione + 15beta,17beta-dihydroxyandrost-4-en-3-one + 11alpha,17beta-dihydroxyandrost-4-en-3-one + 15alpha,17beta-dihydroxyandrost-4-en-3-one + A + H2O

Aspergillus candidus MRC 200634

-

-

745443

-

-

?

androst-4-ene-3,17-dione + AH2 + O2

3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + A + H2O

Rattus norvegicus

-

-

660550

-

-

?

androst-4-ene-3,17-dione + AH2 + O2

3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + A + H2O

Rattus norvegicus

-

enzyme levels increase after exposure of rats to di-n-butyl phthalate

660550

-

-

?

androst-4-ene-3,17-dione + NADPH + O2

3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + NADP+ + H2O

Ilyonectria destructans

-

-

7389

testololactone

7389

?

androst-4-ene-3,17-dione + NADPH + O2

3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + NADP+ + H2O

Purpureocillium lilacinum

-

-

438364

testololactone

438364

?