1.14.99.14: progesterone 11alpha-monooxygenase

This is an abbreviated version!
For detailed information about progesterone 11alpha-monooxygenase, go to the full flat file.

Reaction

Synonyms

CYP106A2, CYP5311B1, progesterone 11alpha-hydroxylase, steroid 11alpha-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.99 Miscellaneous

1.14.99.14 progesterone 11alpha-monooxygenase

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Results	in table
14	Activating Compound
2	AA Sequence
4	Application
1	CAS Registry Number
3	Cloned(Commentary)
11	Cofactor
2	Expression
2	General Stability
11	Inhibitors
15	kcat/KM [mM/s]
14	KM Value [mM]
18	Localization
1	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
49	Organism
1	Pathway
1	pH Optimum
17	Protein Variants
2	Purification (Commentary)
1	Reaction
3	Reaction Type
37	Reference
15	Source Tissue
2	Specific Activity [micromol/min/mg]
61	Substrates and Products (Substrate)
4	Subunits
6	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
15	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.14.99.14 - progesterone 11alpha-monooxygenase

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11-deoxycorticosterone + AH2 + O2

? + A + H2O

2 entries

11-deoxycortisol + AH2 + O2

? + A + H2O

2 entries

16alpha,17-epoxyprogesterone + AH2 + O2

11alpha-hydroxy-16alpha,17-epoxyprogesterone + A + H2O

2 entries

17alpha-hydroxyprogesterone + AH2 + O2

11alpha,17alpha-dihydroxyprogesterone + A + H2O

10 entries

progesterone + AH2 + O2

11alpha-hydroxyprogesterone + A + H2O

3 entries

progesterone + NADPH + O2

11alpha-hydroxyprogesterone + NADP+ + H2O

20 entries

testosterone + AH2 + O2

11alpha-hydroxytestosterone + A + H2O

2 entries

additional information

Priestia megaterium

Q06069

the enzyme is capable of converting useful pharmaceutical targets such as 3-oxo-DELTA4-steroids (e.g., testosterone, 11-deoxycorticosterone, androstenedione, and progesterone) mainly into their 15beta-hydroxy homologues. In addition, the enzyme hydroxylates progesterone to a minor extent at the 11alpha-, 9alpha-, and 6beta-positions

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