1.15.1.2: superoxide reductase
This is an abbreviated version!
For detailed information about superoxide reductase, go to the full flat file.
Word Map on EC 1.15.1.2
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1.15.1.2
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desulfovibrio
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non-heme
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gigas
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desulfoarculus
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baarsii
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sulfate-reducing
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high-spin
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radiolysis
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rubrerythrin
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hildenborough
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hydroperoxo
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peroxo
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square-pyramidal
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ferric-hydroperoxo
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thiolate-ligated
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rubredoxin-like
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feiii-ooh
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agriculture
- 1.15.1.2
- desulfovibrio
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non-heme
- gigas
- desulfoarculus
- baarsii
-
sulfate-reducing
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high-spin
-
radiolysis
- rubrerythrin
- hildenborough
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hydroperoxo
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peroxo
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square-pyramidal
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ferric-hydroperoxo
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thiolate-ligated
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rubredoxin-like
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feiii-ooh
- agriculture
Reaction
Synonyms
1Fe SOR, 1Fe-SOR, 1Fe-superoxide reductase, 2Fe-SOR, class I SOR, class I superoxide reductase, class II SOR, cytochrome c–superoxide oxidoreductase, desulfoferrodoxin, desulforedoxin, Dfx, EC 1.18.96.1, Fe-SOR, GiSOR, MM_0632, More, neelaredoxin, neelaredoxin-type SOR, Nlr, PfSOR, rubredoxin oxidoreductase, SOR, superoxide reductase, TM0658, two-iron superoxide reductase, Zn/Fe-SOR
ECTree
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Reaction
Reaction on EC 1.15.1.2 - superoxide reductase
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
very fast bimolecular reaction of iron center II with superoxide, followed by the formation of two successive intermediate species
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reduction of superoxide may proceed through Fe3+-peroxo intermediates
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
FITR study, presence of E47 is important for the structural reorganization accompanying iron oxidation, catalytic role of K48 is purely electrostatic, guiding superoxide toward the reduced iron
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
in absence of O2.-, reduction potential and absorption spectrum of the iron center II exhibit a pH transition. First reaction intermediate is an iron(III)-peroxo species, second intermediate is an iron(III)-hydroperoxo species
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
presence of Fe(NHis)4(SCys) site is sufficient to catalyze reduction of the intracellular superoxide to nonlethal levels
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
steady state kinetics, diffusion-controlled reaction of reduced enzyme with superoxide is the slowest process during turnover, neither ligation nor deligation of the active site carboxylate limits turnover rate
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
stopped-flow kinetics of electron transfer, second-order rate constant of 10 million M-1 s-1 at 10°C and pH 7.2
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
the iron in the actice site is coordinated through a bent cyano bridge, photo-reduction from FeIII to FeII induces an expansion of the enzyme active site
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
the initial reaction between O2- and Archaeoglobus fulgidus neelaredoxin leads to a short-lived transient that immediately disappears to yield a solvent-bound ferric species in acid-base equilibrium. The final step corresponds to the slow binding of the glutamate sixth ligand to the oxidized iron, a process that may be bypassed during in vivo catalytic turnover of the enzyme
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
the initial reaction involves the formation of a short-lived transient that decays by a proton-dependent step. This process generates an Fe3+–OH species, which is converted to a glutamate-bound one. The function of center I of Dfx remains to be elucidated. The completion of the catalytic cycle of SOR, which involves the re-reduction of the active site, can be attained by reduced rubredoxin
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism
Megalodesulfovibrio gigas
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism, catalytic cycle involving iron complexes, overview
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism, catalytic cycle involving iron complexes, overview
Treponema palladium
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism, catalytic cycle involving iron complexes, overview
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism, catalytic cycle involving iron complexes, overview
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
enzyme active site structure and mechanism, proposed mechanism for SOR-catalyzed reduction of superoxide via hydroperoxo and solvent-bound intermediates, catalytic cycle involving iron complexes, overview
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism involves the diffusion-limited encounter of superoxide with the reduced iron site and concomitant formation of an Fe3+-(hydro)peroxo adduct that, upon protonation, leads to the formation of hydrogen peroxide. By the end of this process, a glutamate residue coordinates the ferric ion, acting as a sixth ligand
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism of SOR involving transfer of an electron and two protons to superoxide to form hydrogen peroxide, kinetic mechanism, detailed overview
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism, the active center of SORs consists of a ferrous ion coordinated by four histidines and one cysteine in a square-pyramidal geometry, formation of a hydroxo-iron ligated species upon the decay of the first transient species followed by conversion to the final species upon binding of the glutamate sixth ligand, phosphate can serve as an exogenous sixth ligand, overview
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism of the SOR with superoxide, overview
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism, geometry of the catalytic center, oxidative cycle/reductive pathway, overview
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism, geometry of the catalytic center, oxidative cycle/reductive pathway, overview
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism, oxidative cycle/reductive pathway, overview
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism, oxidative cycle/reductive pathway, overview
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism, oxidative cycle/reductive pathway, overview
Megalodesulfovibrio gigas
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism, oxidative cycle/reductive pathway, overview
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism, oxidative cycle/reductive pathway, overview
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism, oxidative cycle/reductive pathway, overview
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superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism, oxidative cycle/reductive pathway, overview
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism, oxidative cycle/reductive pathway, overview
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
catalytic mechanism with the first step involving oxidative addition of superoxide to form a ferric-peroxo intermediate. The Fe spin state and the trans cysteinate ligand play an important role in effecting superoxide reduction and peroxide release
superoxide + reduced rubredoxin + 2 H+ = H2O2 + oxidized rubredoxin
reaction mechanism, oxidative cycle/reductive pathway, overview
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