1.16.1.8: [methionine synthase] reductase

This is an abbreviated version!
For detailed information about [methionine synthase] reductase, go to the full flat file.

Word Map on EC 1.16.1.8

1.16.1.8

mthfr

folate

methylenetetrahydrofolate

case-control

gg

hyperhomocysteinemia

one-carbon

cystathionine

tetrahydrofolate

folic

remethylation

thymidylate

beta-synthase

transcobalamin

methylmalonic

megaloblastic

folate-related

spina

bifida

cobiialamin

methyltetrahydrofolate

cobalamin-dependent

homocystinuria

gcpii

diagnostics

t-hcys

medicine

folate-metabolizing

Reaction

2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosyl-L-homocysteine +

= 2 [methionine synthase]-cob(II)alamin +

+ 2 S-adenosyl-L-methionine

Synonyms

EC 2.1.1.135, Methionine synthase cob(II)alamin reductase (methylating), Methionine synthase reductase, MSR, MTRR, NADPH-dependent diflavin oxidoreductase, Reductase, methionine synthase

ECTree

1 Oxidoreductases

1.16 Oxidizing metal ions

1.16.1 With NAD⁺ or NADP⁺ as acceptor

1.16.1.8 [methionine synthase] reductase

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Results	in table
1	Activating Compound
24	AA Sequence
5	Application
1	CAS Registry Number
8	Cloned(Commentary)
37	Cofactor
1	Crystallization (Commentary)
479	Disease/ Diagnostics
1	Expression
9	General Information
7	Inhibitors
12	Ki Value [mM]
21	KM Value [mM]
1	Localization
4	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
22	Organism
1	Pathway
2	PDB ID
5	pH Optimum
13	Protein Variants
3	Purification (Commentary)
4	Reaction
1	Reaction Type
20	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
29	Substrates and Products (Substrate)
7	Subunits
31	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
9	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.16.1.8 - [methionine synthase] reductase

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reduced flavodoxin

Escherichia coli

under anaerobic growth conditions, oxidized ferredoxin (flavodoxin):NADP+ oxidoreductase accepts a hydride from NADPH and transfers the electron to flavodoxin, generating primarily flavodoxin semiquinone. Under anaerobic conditions the decarboxylation of pyruvate is coupled to reduction of flavodoxin, forming the flavodoxin hydroquinone. These reduced forms of flavodoxin bind to inactive cob(II)alamin enzyme, leading to a conformational change that is coupled with dissociation of His759 and protonation of the His759-Asp757-Ser810 triad. Although NADPH oxidation ultimately produces 2 equivalent of flavodoxin semiquinone, only one electron is transferred to methionine synthase during reductive methylation

484890