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1.16.1.9: ferric-chelate reductase (NADPH)

This is an abbreviated version!
For detailed information about ferric-chelate reductase (NADPH), go to the full flat file.

Word Map on EC 1.16.1.9

Reaction

2 Fe(II)-siderophore +

NADP+
+
H+
= 2 Fe(III)-siderophore +
NADPH

Synonyms

FCR, FCR-LM, FCR-Os, Fe(III)-chelate reductase, ferredoxin-NADP(+) oxidoreductase, ferredoxin-NADP+ oxidoreductase, ferri-siderophore reductase, ferric chelate reductase, ferric reductase, ferric siderophore reductase, ferric-chelate reductase, FNR(S), FNRS, FRO1, FRO2, YqjH

ECTree

     1 Oxidoreductases
         1.16 Oxidizing metal ions
             1.16.1 With NAD+ or NADP+ as acceptor
                1.16.1.9 ferric-chelate reductase (NADPH)

Natural Substrates Products

Natural Substrates Products on EC 1.16.1.9 - ferric-chelate reductase (NADPH)

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 Fe(II)-siderophore + NADP+ + H+
2 Fe(III)-siderophore + NADPH
show the reaction diagram
2 Fe(III)-siderophore + NADPH
2 Fe(II)-siderophore + NADP+ + H+
show the reaction diagram
additional information
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DNA degradation occurring in the presence of NADPH, Fe(III)-EDTA and hydrogen peroxide is potently enhanced by the purified enzyme, indicating that the enzyme may drive the Fenton reaction, reducing ferric iron to ferrous iron when it evokes the Fenton reaction
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