1.17.1.4: xanthine dehydrogenase

This is an abbreviated version!
For detailed information about xanthine dehydrogenase, go to the full flat file.

Reaction

Synonyms

AtXDH1, EC 1.1.1.204, EC 1.2.1.37, IAO1, More, NAD-xanthine dehydrogenase, PaoABC, Retinol dehydrogenase, Rosy locus protein, VvXDH, xanthine dehydrogenase, xanthine dehydrogenase-1, xanthine dehydrogenase-2, xanthine dehydrogenase/oxidase, xanthine oxidoreductase, xanthine-NAD oxidoreductase, xanthine/NAD+ oxidoreductase, xanthine:NAD+ oxidoreductase, XDH, XDH/XO, XDH1, XDH2, XdhC, XOR, YagR, YagS, YagT

ECTree

     1 Oxidoreductases

         1.17 Acting on CH or CH₂ groups

             1.17.1 With NAD⁺ or NADP⁺ as acceptor

                1.17.1.4 xanthine dehydrogenase

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Results	in table
22	Activating Compound
13818	AA Sequence
34	Application
1	CAS Registry Number
36	Cloned(Commentary)
299	Cofactor
22	Crystallization (Commentary)
40	Disease/ Diagnostics
3	Expression
84	General Information
9	General Stability
175	Inhibitors
19	kcat/KM [mM/s]
3	Ki Value [mM]
170	KM Value [mM]
22	Localization
133	Metals/Ions
86	Molecular Weight [Da]
237	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
225	Organism
1	Oxidation Stability
14	Pathway
110	PDB ID
45	pH Optimum
8	pH Range
8	pH Stability
1	pI Value
4	Posttranslational Modification
79	Protein Variants
71	Purification (Commentary)
9	Reaction
3	Reaction Type
205	Reference
2	Renatured (Commentary)
217	Source Tissue
65	Specific Activity [micromol/min/mg]
8	Storage Stability
572	Substrates and Products (Substrate)
66	Subunits
107	Synonyms
1	Systematic Name
32	Temperature Optimum [°C]
1	Temperature Range [°C]
22	Temperature Stability [°C]
55	Turnover Number [1/s]

Organism

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Organism on EC 1.17.1.4 - xanthine dehydrogenase

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Acinetobacter baumannii

-

744450

-

-

brenda

Acinetobacter phage Ab105-3phi

-

744450

-

-

brenda

Aedes aegypti

-

744865

A0A1S4F2J6, A0A1S4G2F8

UniProt

brenda

Alcaligenes sp.

-

644594

-

-

brenda

Arabidopsis thaliana

4 entries

Arabidopsis thaliana Col-0

-

746009, 746030, 746031

Q8GUQ8

Swissprot

brenda

Arthrobacter luteolus

-

744450

-

-

brenda

Arthrobacter sp.

-

644594

-

-

brenda

Bacillus sp. (in: Bacteria)

-

644594

-

-

brenda

Bacillus subtilis

-

644569

-

-

brenda

Bombyx mori

-

762824

Q17209

UniProt

brenda

Bos taurus

7 entries

Calliphora vicina

-

644575

-

-

brenda

Camelus dromedarius

-

657699

-

-

brenda

Capra hircus

-

659580, 674020

-

-

brenda

Chlamydomonas reinhardtii

-

644573, 644590, 644611

-

-

brenda

Clostridium cylindrosporum

-

644614, 744450

-

-

brenda

Clostridium sp.

-

644594

-

-

brenda

Colias eurytheme

-

644607

-

-

brenda

Delftia acidovorans

4 entries

Drosophila melanogaster

-

644560, 644578, 644584, 644595, 644596, 644598, 644605, 644610, 744450

-

-

brenda

Enterobacter cloacae

-

744450

-

-

brenda

Enterococcus faecalis

gene xdh

715377

-

-

brenda

Escherichia coli

2 entries

Escherichia sp.

-

644594

-

-

brenda

Eubacterium barkeri

-

644566

-

-

brenda

Fusarium verticillioides

-

688044

-

-

brenda

Gallus gallus

3 entries

Glycine max

soybean

644602, 644609

-

-

brenda

Gottschalkia acidurici

-

644592, 644614

-

-

brenda

Gottschalkia purinilytica

2 entries

Homo sapiens

4 entries

Lactobacillus sp.

-

644594

-

-

brenda

Mammalia

-

746030

-

-

brenda

Meleagris gallopavo

turkey

644574, 644615

-

-

brenda

Micrococcus sp.

-

744450

-

-

brenda

Microsporum canis

-

688044

-

-

brenda

Mus musculus

3 entries

Neurospora crassa

-

644604

-

-

brenda

Nicotiana plumbaginifolia

-

644586

-

-

brenda

no activity in Columba livia

-

644582

-

-

brenda

no activity in Klebsiella sp.

-

644594

-

-

brenda

Nocardia sp.

-

644594

-

-

brenda

Oryctolagus cuniculus

rabbit

644557, 644558

-

-

brenda

Ovis aries

-

659580, 744450

-

-

brenda

Penicillium chrysogenum

-

688044

-

-

brenda

Penicillium sp.

-

644594

-

-

brenda

Peptococcus sp.

-

644594

-

-

brenda

Persea americana

Mill cv. Hass

656630

-

-

brenda

Pisum sativum

2 entries

Pseudomonas aeruginosa

ATCC strain 15692

660785, 661289

-

-

brenda

Pseudomonas putida

-

644561, 644562, 644593, 644594, 744450

-

-

brenda

Pseudomonas putida 40

-

644594

-

-

brenda

Pseudomonas putida 86

-

644562

-

-

brenda

Pseudomonas sp.

-

644594

-

-

brenda

Pseudomonas synxantha

-

644617

-

-

brenda

Rattus norvegicus

10 entries

Rattus sp.

-

394699, 644559, 644563, 644571, 644580, 644582, 644587, 644591, 644599, 644600, 644601

-

-

brenda

Rhodobacter capsulatus

7 entries

Rhodobacter capsulatus B10XDHB

-

744450

-

-

brenda

Rhodobacter capsulatus CGMCC 1.3366

2 entries

Serratia marcescens

-

688044

-

-

brenda

Serratia sp.

-

644594

-

-

brenda

Solanum lycopersicum

induction by application of abscisic acid and in water-stressed leaves and roots

660183

-

-

brenda

Staphylococcus aureus

-

688044

-

-

brenda

Streptomyces cyanogenus

-

644616, 744450

-

-

brenda

Streptomyces sp.

-

644594

-

-

brenda

Sus scrofa

-

728624

-

-

brenda

Trichoderma viride

-

688044

-

-

brenda

Triticum aestivum

wheat

644568

-

-

brenda

Veillonella atypica

2 entries

Veillonella sp.

-

644594

-

-

brenda

Vitis vinifera

-

746016

F6GU50

UniProt

brenda

Arabidopsis thaliana

-

706259

-

-

brenda

Arabidopsis thaliana

-

706259, 744450, 746009, 746030, 746031

Q8GUQ8

Swissprot

brenda

Arabidopsis thaliana

induction by application of abscisic acid and in water-stressed leaves and roots

660183

-

-

brenda

Arabidopsis thaliana

isozyme XDH1, expression in Pichia pastoris

659314

Q8GUQ8

Swissprot

brenda

Bos taurus

-

644555, 644564, 644567, 644587, 644588, 644595, 644618

-

-

brenda

Bos taurus

-

659205

P80457

UniProt

brenda

Bos taurus

-

659210, 659580

-

-

brenda

Bos taurus

-

660378

P80457

UniProt

brenda

Bos taurus

-

671830, 687105, 688558, 689276, 689277, 703626, 715273

-

-

brenda

Bos taurus

-

727682

P80457

UniProt

brenda

Bos taurus

-

744450

-

-

brenda

Delftia acidovorans

-

644581, 644583

-

-

brenda

Delftia acidovorans

expression in Pseudomonas aeruginosa, for maximal level of functional expression, co-expression of xdhC gene is required which increases level of molybdenum incorporation. Iron and FAD content of expressed enzymes are independent of xdhC expression

660439

-

-

brenda

Delftia acidovorans

large subunit; expression of genes xdhAB encoding the two subunits of enzyme, in Escherichia coli, produces active enzyme. Coexpression of xdhAB genes with Pseudomonas aeruginosa xdhC gene results in high levels of functional protein

658630

Q8RLC0

Swissprot

brenda

Delftia acidovorans

small subunit; expression of genes xdhAB encoding the two subunits of enzyme, in Escherichia coli, produces active enzyme. Coexpression of xdhAB genes with Pseudomonas aeruginosa xdhC gene results in high levels of functional protein

658630

Q8RLC1

Swissprot

brenda

Escherichia coli

P77165 i.e. alpha-subunit, P77324 i.e. beta-subnit, P77489 i.e. gamma-subunit

739772

P77165; P77324; P77489

UniProt

brenda

Escherichia coli

subunits encoding genes xdhA and xdhB

744450

Q46799; Q46800

UniProt

brenda

Gallus gallus

-

688044, 703626, 706471, 728646, 744450

-

-

brenda

Gallus gallus

chicken

644556, 644572, 644576, 644579, 644582, 644606, 644613

-

-

brenda

Gallus gallus

domesticus, male chicken

703310

-

-

brenda

Gottschalkia purinilytica

-

644577

-

-

brenda

Gottschalkia purinilytica

increase in activity upon growth on selenite or molybdate, xanthine or uric acid

659012

-

-

brenda

Homo sapiens

-

644557, 644585, 659580

-

-

brenda

Homo sapiens

-

671830

P47989

Uniprot

brenda

Homo sapiens

-

674374, 686354, 687354, 687917, 703626, 704789, 704842, 744450

-

-

brenda

Homo sapiens

dehydrogenase activity predominant form

644558

-

-

brenda

Mus musculus

-

644565, 672979, 687917

-

-

brenda

Mus musculus

hyperuricemic mice induced by potassium oxonate

675113

-

-

brenda

Mus musculus

with ventilator-induced lung injury

671254

-

-

brenda

Pisum sativum

-

644589, 660263

-

-

brenda

Pisum sativum

-

688639

B3FYT9

Uniprot

brenda

Rattus norvegicus

-

657487, 659481, 673806, 675020, 687214, 687817, 689276, 702963, 703626, 744450

-

-

brenda

Rattus norvegicus

-

744875

P22985

UniProt

brenda

Rattus norvegicus

cf. EC 1.17.3.2

715273

P22985

UniProt

brenda

Rattus norvegicus

conversion of oxidoreductatse to oxidase

674375

P22985

UniProt

brenda

Rattus norvegicus

expression of enzyme in baculovirus-insect cell system, yields a mixture of native dimeric, demolydbo-dimeric and monomeric forms. All forms contain flavin, the monomeric forms lack molybdopterin and the iron-sulfur centers. Monomeric forms require only three electrons for complete reduction

659079

-

-

brenda

Rattus norvegicus

male and female Crj:CD(SD)IGS rats and male Sprague-Dawley rats

706838

-

-

brenda

Rattus norvegicus

male Sprague-Dawley rats, potassium oxonate-induced hyperuricemic rats

706057

-

-

brenda

Rattus norvegicus

male Wistar rats

704822

-

-

brenda

Rattus norvegicus

treated for 7 days with cocaine, or cocaine with a NADPH oxidase inhibitor apocynin, or cocaine with a xanthine oxidoreductase inhibitor allopurinol

688448

-

-

brenda

Rattus norvegicus

Wistar rats

701944

-

-

brenda

Rhodobacter capsulatus

-

644603, 644608, 659390, 674566, 674793, 703626, 704425

-

-

brenda

Rhodobacter capsulatus

-

704636

O54050

SwissProt

brenda

Rhodobacter capsulatus

-

715157, 728189, 744450, 745069

-

-

brenda

Rhodobacter capsulatus

expression in Escherichia coli

659210

-

-

brenda

Rhodobacter capsulatus

genes XdhA and XdhB

744521

O54050; O54051

UniProt

brenda

Rhodobacter capsulatus

small and large subunits encoded by genes xdhA and xdhB

743904, 745314

O54050; O54051

UniProt

brenda

Rhodobacter capsulatus

small and large subunits encoded by genes xdhA and xdhB, and chaperone encoded by gene xdhC

744255

O54050; O54051; Q9X7K2

UniProt

brenda

Rhodobacter capsulatus CGMCC 1.3366

genes XdhA and XdhB

744521

O54050; O54051

UniProt

brenda

Rhodobacter capsulatus CGMCC 1.3366

small and large subunits encoded by genes xdhA and xdhB, and chaperone encoded by gene xdhC

744255

O54050; O54051; Q9X7K2

UniProt

brenda

Veillonella atypica

-

644597

-

-

brenda

Veillonella atypica

formerly Micrococcus lactilyticus or Veillonella alcalescens

644570

-

-

brenda