1.17.1.8: 4-hydroxy-tetrahydrodipicolinate reductase
This is an abbreviated version!
For detailed information about 4-hydroxy-tetrahydrodipicolinate reductase, go to the full flat file.
Word Map on EC 1.17.1.8
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1.17.1.8
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diaminopimelate
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glutamicum
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meso-diaminopimelate
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aspartokinase
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imine
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dhdps
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2,6-pyridinedicarboxylate
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medicine
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alpha,beta-unsaturated
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2'-phosphate
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s-2-aminoethyl-l-cysteine
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aspartate-semialdehyde
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drug development
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agriculture
- 1.17.1.8
- diaminopimelate
- glutamicum
- meso-diaminopimelate
- aspartokinase
- imine
- dhdps
- 2,6-pyridinedicarboxylate
- medicine
-
alpha,beta-unsaturated
-
2'-phosphate
- s-2-aminoethyl-l-cysteine
-
aspartate-semialdehyde
- drug development
- agriculture
Reaction
Synonyms
AbDHDPR, CRR1, DapB, DHDP reductase, DHDPR, DHPR, dihydrodipicolinate reductase, dihydrodipicolinate reductase-like protein, dihydrodipicolinic acid reductase, EC 1.3.1.26, MRSA-DHDPR, reductase, dihydrodipicolinate
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Cofactor
Cofactor on EC 1.17.1.8 - 4-hydroxy-tetrahydrodipicolinate reductase
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NADH
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dihydrodipicolinate reductase activity requires NADH binding at only one of the four monomers
NADH
the enzyme utilizes both NADH and NADPH as cofactors. The mode of cofactor binding to the enzyme is elucidated by determining the crystal structure of the enzyme in complex with NADP+
NADH
the histidine-tagged enzyme also uses both NADH and NADPH as substrates
NADPH
the enzyme utilizes both NADH and NADPH as cofactors. The mode of cofactor binding to the enzyme is elucidated by determining the crystal structure of the enzyme in complex with NADP+
NADPH
the histidine-tagged enzyme also uses both NADH and NADPH as substrates
broad pyridine nucleotide specificity, binding study with NADPH, NADH, 3-acetyl-NADH, and nicotinamide hypoxanthine dinucleotide phosphate reduced and other pyridine nucleotide derivatives
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additional information
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broad pyridine nucleotide specificity, binding study with NADPH, NADH, 3-acetyl-NADH, and nicotinamide hypoxanthine dinucleotide phosphate reduced and other pyridine nucleotide derivatives
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additional information
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stereospecific transfer of the 4R hydrogen atom of the reduced nucleotide, as a hydrid ion, to the 4 position of dihydrodipicolinate
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