1.17.3.3: 6-hydroxynicotinate dehydrogenase
This is an abbreviated version!
For detailed information about 6-hydroxynicotinate dehydrogenase, go to the full flat file.
Reaction
Synonyms
6-HDH, 6-hydroxynicotinate hydroxylase, 6-hydroxynicotinic acid dehydrogenase, 6-hydroxynicotinic acid hydroxylase, dehydrogenase, 6-hydroxynicotinate
ECTree
1.17.3.3 6-hydroxynicotinate dehydrogenaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.17.3.3 - 6-hydroxynicotinate dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-hydroxynicotinate + H2O + 2,6-dichlorophenol indophenol
2,6-dihydroxynicotinate + H2O2 + reduced 2,6-dichlorophenol indophenol
-
highly specific for 6-hydroxynicotinate, transfers electrons only to artificial acceptors of high redox potential, the mixture of phenazine ethosulfate and 2,6-dichlorophenol indophenol is a good electron acceptor
-
?
6-hydroxynicotinate + H2O + methylene blue
2,6-dihydroxynicotinate + H2O2 + reduced methylene blue
-
highly specific for 6-hydroxynicotinate, transfers electrons only to artificial acceptors of high redox potential, 40% of the activity with the mixture of phenazine ethosulfate and 2,6-dichlorophenol indophenol
-
?
6-hydroxynicotinate + H2O + nitroblue tetrazolium chloride
2,6-dihydroxynicotinate + H2O2 + reduced nitroblue tetrazolium chloride
-
highly specific for 6-hydroxynicotinate, transfers electrons only to artificial acceptors of high redox potential, same activity as with the mixture of phenazine ethosulfate and 2,6-dichlorophenol indophenol
-
?
6-hydroxynicotinate + H2O + phenazine ethosulfate
2,6-dihydroxynicotinate + H2O2 + reduced phenazine ethosulfate
-
highly specific for 6-hydroxynicotinate, transfers electrons only to artificial acceptors of high redox potential, the mixture of phenazine ethosulfate and 2,6-dichlorophenol indophenol is a good electron acceptor
-
?
6-hydroxynicotinate + H2O + thiazolyl blue
2,6-dihydroxynicotinate + H2O2 + reduced thiazolyl blue
-
highly specific for 6-hydroxynicotinate, transfers electrons only to artificial acceptors of high redox potential, same activity as with the mixture of phenazine ethosulfate and 2,6-dichlorophenol indophenol
-
?
6-hydroxynicotinate + H2O + thionin
2,6-dihydroxynicotinate + H2O2 + reduced thionin
-
highly specific for 6-hydroxynicotinate, transfers electrons only to artificial acceptors of high redox potential, 2% of the activity with the mixture of phenazine ethosulfate and 2,6-dichlorophenol indophenol
-
?
6-hydroxynicotinate + H2O + O2
2,6-dihydroxynicotinate + H2O2
-
-
-
-
?
6-hydroxynicotinate + H2O + O2
2,6-dihydroxynicotinate + H2O2
-
-
-
?
6-hydroxynicotinate + H2O + O2
2,6-dihydroxynicotinate + H2O2
-
-
-
?
6-hydroxynicotinate + H2O + O2
2,6-dihydroxynicotinate + H2O2
-
highly specific for 6-hydroxynicotinate
-
?
additional information
?
-
-
no electron acceptors: Brilliant cresyl blue, cytochrome c, FAD, ferricyanide, FMN, menadione, NAD+, NADP+, and both viologens
-
?
additional information
?
-
-
acts together with nicotinate dehydrogenase in nicotinate catabolism
-
?
additional information
?
-
-
catalyzes the second step in the degradation of nicotinate
-
?
