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UniProt
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UniProt
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UniProt
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nrdA and nrdB genes encoding a CDP reductase are induced by oxidative stress
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Cinqassovirus aeh1
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gene nrdF encoding subunit R2F
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gene nrdF encoding subunit R2F
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Chinese hamster overy cells
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genes nrdE and nrdF encoding the subunits alpha2 and beta2
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genes nrdA and nrdB encoding subunits R1 and R2, respectively
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overproducing strain
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an oncovirus belonging to the gamma-subfamily of human herpesviruses
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3D7
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monkey kidney cells BSC-40 induced by vaccina virus strain WR, activity may be virally encoded
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SwissProt
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A3CLZ6: subunit alpha (NrdE), A3CLZ4: subunit beta (NrdF)
UniProt
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A3CLZ6: subunit alpha (NrdE), A3CLZ4: subunit beta (NrdF)
UniProt
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Uniprot
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small subunit A, R2A; var. Columbia, ecotype Columbia-0, three AtRNR2-like catalytic subunit genes AtTSO2, AtRNR2A, and AtRNR2B
UniProt
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small subunit B, R2B; var. Columbia, ecotype Columbia-0, three AtRNR2-like catalytic subunit genes AtTSO2, AtRNR2A, and AtRNR2B
SwissProt
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small subunit C, TSO2; var. Columbia, ecotype Columbia-0, three AtRNR2-like catalytic subunit genes AtTSO2, AtRNR2A, and AtRNR2B
UniProt
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UniProt
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strain ATCC 14579
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calf
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Uniprot
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a human pathogen
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class Ib reductase
UniProt
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strain ATCC 6872, gene nrdF
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437909, 437918, 437921, 437924, 437927, 437928, 437936, 437937, 437938, 437939, 437940, 437941, 437942, 437945, 437946, 437953, 437955, 437957, 437958, 437959, 437965, 437976 -
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Uniprot
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Uniprot
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UniProt
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genes nrdA and nrdB encoding subunits R1 and R2, respectively
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genes nrdE and nrdF encoding the subunits alpha2 and beta2
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isoform NrdA
UniProt
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isoform NrdE
UniProt
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overproducing strain
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P00452: subunit alpha (NrdA), P69924: subunit beta (NrdB)
SwissProt
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P00452: subunit NrdA, P69924: subunit NrdB
SwissProt
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use of crystal structure for modeling of active site
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Herpes simplex virus
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Herpes simplex virus
type 1, HSV-1
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Herpes simplex virus
type 2, HSV-2
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Uniprot
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684464, 685023, 688244, 688283, 702161, 702259, 702551, 715085, 716318, 716792, 726918, 728343 -
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adults with refractory acute leukemias and aggressive myeloproliferative disorders, MPD
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HeLa cells
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isoform p53R2
SwissProt
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Molt 4F cells
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P23921: ribonucleoside-diphosphate reductase large subunit RRM1, P31350: ribonucleoside-diphosphate reductase subunit RRM2
SwissProt
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patients with advanced myeloid leukemia
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ribonucleoside-diphosphate reductase large subunit
Uniprot
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ribonucleoside-diphosphate reductase subunit M2 B
SwissProt
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ribonucleotide reductase subunit M2 (RRM2)
UniProt
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small subunit RIR2
UniProt
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subunit RRM2B
SwissProt
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baby hamster kidney cells, enzyme induced by Herpes simplex, virus type 1, HSV-1
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437907, 437909, 437936, 437944, 437947, 437951, 437952, 437960, 437983, 437985, 437987, 437989, 437990, 657491, 658677, 672581, 672909, 674631, 674645, 688244, 715085 -
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Ehrlich ascites tumor cells
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female BALB/c mice and A/J mice
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M2 subunit; BALB/3T3 cells, ATCC CCL 163
SwissProt
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mutant line of T-lymphoma S49 cells
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recombinant enzyme
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wild-type and reductase inhibitor resistant L1210 cell line
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P9WH75: large, catalytic subunit, P9WH73: small, cofactor-housing subunit R2F-1, P9WH71: small, cofactor-housing subunit R2F-2. The active class Ib ribonucleotide reductase can use two different small subunits, R2F-1 and R2F-2, with similar activity
SwissProt
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strain strain H37Rv, gene Rv3051c
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large subunit, gene V3; subsp. japonica, genes virescent3, V3, and stripe1, Str1, encoding the large and small subunits, RNRL1, and RNRS1
UniProt
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small subunit, gene Str1; subsp. japonica, genes virescent3, V3, and stripe1, Str1, encoding the large and small subunits, RNRL1, and RNRS1
UniProt
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enzyme is a complex of the NrdA protein harboring the active site and the allosteric sites and the NrdB protein harboring a tyrosyl radical
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NrdA
UniProt
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Morris hepatoma cells
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non-proliferating cells inactivate 88000-90000 Da M1 subunit by degradation into 40000 Da fragments
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Novikoff hepatoma cells
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Uniprot
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Uniprot
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large subunit 1
Uniprot
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modulation of concentration of tyrosyl radicals is not involved in the regulation of enzyme activity
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class I ribonucleotide reductase
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serovar Typhimurium, inside RAW264.7 macrophages or HeLa cells
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Tequatrovirus T4
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Tequatrovirus T4
enzyme induced in Escherichia coli by infection with bacteriophage T4
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Tequintavirus T5
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Tequintavirus T5
may use triphosphates as substrates
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green algae
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