1.17.4.1: ribonucleoside-diphosphate reductase

This is an abbreviated version!
For detailed information about ribonucleoside-diphosphate reductase, go to the full flat file.

Reaction

Synonyms

2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase, ADP reductase, CDP reductase, class I ribonucleotide reductase, class I ribonulceotide reductase, class I RNR, class I RR, class Ia ribonucleotide reductase, class Ia RNR, class Ia RR, class Ib ribonucleotide reductase, class Ib RNR, class Ic ribonucleotide reductase, class II RNR, manganese-ribonucleotide reductase, Mn-RNR, More, mRR, NrdA, NrdB, NrdE, NrdF, nucleoside diphosphate reductase, p53-inducible ribonucleotide reductase, R2F, reductase, ribonucleoside diphosphate, ribonucleoside 5'-diphosphate reductase, ribonucleoside diphosphate reductase, ribonucleoside-diphosphate reductase subunit M2 B, ribonucleotide diphosphate reductase, ribonucleotide reductase, RIR1, RIR2, RNR, RNR1 rRibonucleoside-diphosphate reductase large chain 1, RNR2, UDP reductase

ECTree

     1 Oxidoreductases

         1.17 Acting on CH or CH₂ groups

             1.17.4 With a disulfide as acceptor

                1.17.4.1 ribonucleoside-diphosphate reductase

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Results	in table
306	Activating Compound
93601	AA Sequence
18	Application
1	CAS Registry Number
42	Cloned(Commentary)
61	Cofactor
22	Crystallization (Commentary)
147	Disease/ Diagnostics
9	Expression
47	General Information
6	General Stability
27	IC50 Value
482	Inhibitors
40	Ki Value [mM]
40	KM Value [mM]
14	Localization
120	Metals/Ions
52	Molecular Weight [Da]
63	Natural Substrates/ Products (Substrates)
248	Organism
2	Oxidation Stability
18	Pathway
527	PDB ID
18	pH Optimum
2	pH Range
67	Protein Variants
47	Purification (Commentary)
26	Reaction
3	Reaction Type
237	Reference
87	Source Tissue
49	Specific Activity [micromol/min/mg]
10	Storage Stability
277	Substrates and Products (Substrate)
110	Subunits
155	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
2	Temperature Range [°C]
1	Temperature Stability [°C]
7	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 1.17.4.1 - ribonucleoside-diphosphate reductase

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-15°C or -70°C, 10 mM histidine-HCl, pH 7.0, 2 mM dithiotreitol, 40% glycerol, 2 mM ATP, 6 months, no loss of activity

Oryctolagus cuniculus

-

437966

-15°C, 10 mM histidine-HCl, pH 7.0, 2 mM dithiotreitol, 2 mM ATP, 6 months, 80% loss of activity

Oryctolagus cuniculus

-

437966

-70°, 50 mM Tris-HCl, pH 7.6, 100 mM KCl, several months, no loss of activity

Bos taurus

-

437965

-70°C, 10 mM histidine-HCl, pH 7.0, 2 mM dithiothreitol, 2 mM ATP, 6 months 60% loss of activity

Oryctolagus cuniculus

-

437966

-70°C, 100 mM potassium phosphate, pH 7.0, 1 mM dithiothreitol, enzyme concentration 4.8 mg/ml, 6 months, no loss of activity

Tequatrovirus T4

-

437911

-70°C, up to 8 months, no loss of activity

Herpes simplex virus

-

437964

-80°C, 0.25 M sucrose, 100 mM Tris-HCl, pH 7.6, 10 mM MgCl2, 2 mM dithiothreitol, 1 month, no loss of activity

Rattus norvegicus

-

437962

-80°C, several months, no loss of activity

Vaccinia virus

-

437974

4°C, at least 24 h, no loss of activity

Herpes simplex virus

-

437964

quick-freezing in liquid nitrogen and subsequent storage at -20°C, several weeks, no loss of activity

Saccharomyces cerevisiae

-

437948